Evidence of Neuronal Compensation During Episodic Memory in Subjective Memory Impairment

Erk, Susanne; Spottke, Annika; Meisen, Alice; Wagner, Michael; Walter, Henrik; Jessen, Frank

doi:10.1001/archgenpsychiatry.2011.80

Cited by 133 publications

(126 citation statements)

References 56 publications

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“…It has been suggested that memory breakdown in AD is related to a marked reduction of integrated activity within a distributed network, including hippocampus and DLPFC (Grady et al, 2001). Further support for the relevance of hippocampal-prefrontal interaction in AD risk was given by a recent study by our group, where we demonstrated that subjective memory impairment-an early, pre-MCI stage in the continuum of Alzheimer's disease manifestation-is characterized by early hippocampal dysfunction and increased compensatory effort, reflected in DLPFC activation, to enable sustained performance in the presence of early pathology (Erk et al, 2011). A recent fMRI study provided evidence for aberrant activation in the same regions, namely DLFPC and hippocampus, during working memory performance in a small sample of healthy young individuals genotyped for rs11136000 (Lancaster et al, 2011).…”

Section: Discussionsupporting

confidence: 64%

“…During fMRI scanning, subjects completed three consecutive blocks of memory tasks, based on a paradigm previously used for imaging genetics, as part of a functional imaging genetics battery (Erk et al, 2010(Erk et al, , 2011. The encoding task consisted of 16 face-profession pairs and 24 head contours with four blocks of four face-profession pairs and four blocks of six head contours each.…”

Section: Methodsmentioning

confidence: 99%

“…To test for the functional relevance of CLU rs11136000 during episodic memory, a process mediated through hippocampal function and crucially affected by AD, we used fMRI in healthy participants genotyped for rs11136000 and a task optimized for imaging genetics that allows probing of different cognitive subprocesses of episodic memory, i.e., encoding, recall, and recognition of associative episodic information (Erk et al, 2010(Erk et al, , 2011. We studied task-related regional activation as well as functional coupling, using functional connectivity, a well established method that measures correlation between BOLD time series in different brain regions that has been used successfully to delineate the functional anatomy of brain interactions and the impact of genetic variation (Esslinger et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hippocampal Function in Healthy Carriers of theCLUAlzheimer's Disease Risk Variant

Erk¹,

Meyer‐Lindenberg²,

Boberfeld³

et al. 2011

J. Neurosci.

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Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.

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Section: Discussionsupporting

confidence: 64%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hippocampal Function in Healthy Carriers of theCLUAlzheimer's Disease Risk Variant

Erk¹,

Meyer‐Lindenberg²,

Boberfeld³

et al. 2011

J. Neurosci.

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“…SCC has also been found to be associated with the use of more compensatory strategies such as increased effort, cognitive strategies and use of external aids/tools (Garrett et al 2010). These reported phenomena converge with others' findings of compensatory neural activation patterns during episodic (Erk et al 2011) and working memory tasks (Sandström et al 2012) in individuals with SCC (compared to controls) even when no decrements in task performance are seen.…”

Section: Discussionsupporting

confidence: 78%

“…Recently, various neuroimaging studies on elderly participants have found SCC (even without manifest cognitive impairments) to be related to altered neuronal/ brain functioning that may be non-pathological or Erk et al 2011;Scheef et al 2012;Striepens et al 2010;Hohman et al 2011). This suggests that people may have awareness of changes in cognitive and brain functioning even when these are not detectable from conventional neuropsychological assessments.…”

Section: Discussionmentioning

confidence: 99%

Are subjective cognitive complaints related to memory functioning in the working population?

et al. 2014

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Background: Cognitive functioning is important for managing work and life in general. Some experience problems with cognitive functioning, often referred to as subjective cognitive complaints (SCC). These problems are rather prevalent in the working population and can be coupled with both lowered well-being and work ability. However, the relation between SCC and memory functioning across the adult age-span, and in the work force, is not clear as few population-based studies have been conducted on non-elderly adults. Thus, the present study aimed to test the relation between SCC and actual declarative memory functioning in a population-based sample of employees. Methods: Participants were 233 employees with either high (cases) or low (controls) levels of SCC. Group differences in neuropsychological tests of semantic and episodic memory, as well as episodic memory performance during higher executive demands (divided attention) were analysed through a set of analyses of covariance tests. Results: Significantly poorer episodic memory performance during divided attention (i.e. high executive demands) was found in the group with high SCC compared to controls with little SCC, while no group differences were found in semantic memory. No group differences were found in immediate or delayed episodic memory during focused attention conditions. Furthermore, depressive symptoms, chronic stress symptoms and sleeping problems were found to play a role in the relation between SCC and episodic memory during divided attention. Conclusions: This study contributes to an increased understanding of what characterizes SCC in the work force and suggests a relation to poorer executive cognitive functioning.

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Treatment evaluation of Kami Guibi‐tang on participants with amnestic mild cognitive impairment using magnetic resonance imaging on brain metabolites, gamma‐aminobutyric acid, and cerebral blood flow

Cho

Kwon

Shin

et al. 2021

J Applied Clin Med Phys

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Purpose To evaluate the effectiveness of Kami Guibi‐tang (KGT) in the treatment of mild cognitive impairment (MCI) using magnetic resonance imaging (MRI) on brain metabolites, neurotransmitter, and cerebral blood flow (CBF). Methods We randomly allocated a total of 30 MCI patients to a KGT (N = 16) or a placebo (N = 14) group and performed MRI scans before and after 24 weeks of treatment. The participants underwent brain magnetic resonance spectroscopy and MRI scans to obtain brain metabolites using Point‐RESolved Spectroscopy (PRESS) single‐voxel spectroscopy, gamma‐aminobutyric acid (GABA) neurotransmitter using Mescher–Garwood PRESS, and CBF using pseudocontinuous arterial spin labeling sequences using a 3.0 Tesla MRI system. We analyzed metabolite and neurotransmitter levels and CBF using repeated‐measure analysis of variance to evaluate between‐subject group effect, within‐subject treatment condition effect, and interaction of group by condition (group x condition). Results The GABA+/creatine (Cr) ratio values were not significantly different between the before and after treatment conditions. The glutamate complex/Cr ratio difference before and after treatment was lower in the KGT group than in the placebo group, but was not statistically significant (p = 0.077). The result of region of interest–based CBF measurement showed that CBF values were significantly lower after treatment at Cluster 2 for the KGT group (p = 0.003) and the placebo group (p = 0.011), at hippocampus for the KGT group (p = 0.004) and the placebo group (p = 0.008), and at the fusiform gyrus for the KGT group (p = 0.002). Furthermore, the absolute CBF difference before and after treatment in the fusiform gyrus was significantly lower in the KGT group than in the placebo group (p = 0.024). Conclusions Although a KGT treatment of 24 weeks showed some significant impact on the level of CBF, the Korean version of the mini‐mental state examination score was not significantly different between before and after treatment conditions, indicating that there was no memory function improvement after treatment in amnestic MCI patients. Therefore, further studies should be performed with a relatively larger population and extending the duration of the KGT treatment.

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Evidence of Neuronal Compensation During Episodic Memory in Subjective Memory Impairment

Abstract: These results suggest that SMI is accompanied by functional alterations in hippocampal integrity that reflect early neuronal dysfunction and by compensatory mechanisms that preserve memory performance.

Cited by 133 publications

References 56 publications

Hippocampal Function in Healthy Carriers of theCLUAlzheimer's Disease Risk Variant

Hippocampal Function in Healthy Carriers of theCLUAlzheimer's Disease Risk Variant

Are subjective cognitive complaints related to memory functioning in the working population?

Treatment evaluation of Kami Guibi‐tang on participants with amnestic mild cognitive impairment using magnetic resonance imaging on brain metabolites, gamma‐aminobutyric acid, and cerebral blood flow

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