Evidence of Low Adherence to Stimulant Medication Among Children and Youths With ADHD: An Electronic Health Records Study

Biederman, Joseph; Fried, Roland; DiSalvo, Maura; Storch, Barbara; Pulli, Alexa; Woodworth, K. Yvonne; Biederman, Itai; Faraone, Stephen V.; Perlis, Roy H.

doi:10.1176/appi.ps.201800515

Cited by 40 publications

(31 citation statements)

References 46 publications

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“…The types of diseases screened and predicted are mostly serious diseases that difficult to overcome, such as cancer [68], diabetes [69], and Alzheimer's disease [70]. The research subjects cover people of different ages, genders, and occupations, including not only children [71], youth [72], and the elderly [73], but also women [74] and veterans [75].…”

Section: Population Health Disease Risk Prediction and Primary Carementioning

confidence: 99%

Exploring the Landscape, Hot Topics, and Trends of Electronic Health Records Literature with Topics Detection and Evolution Analysis

Qian¹,

Ni²,

Gui³

et al. 2021

IJCIS

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Electronic health records (EHRs)-related publications grow rapidly. It is helpful for experts and scholars in various disciplines to better understand the research landscape, hot topics, and trends of EHRs. We collected 13,438 records of EHRs research literature bibliometrics data from the Web of Science. We mainly performed the descriptive statistical analysis, social network analysis, and topic modeling with lda2vec to reveal the publications growth trend, research subjects distribution, and topics of EHRs researches. The EHRs research mainly included four topics: (i) population health, disease risk prediction, and primary care; (ii) technology, ethics, and privacy security; (iii) quality improvement, user acceptance, and engagement; (iv) information systems application and impact. EHRs have gone through the establishment, utilization, and high-level development and application. Research topics emerging in recent years have primarily focused on the social determinants of health, the application of deep learning models, the development and utilization of the patient portal, the mining of explicit and tacit knowledge, and the provision of decision support.

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Section: Population Health Disease Risk Prediction and Primary Carementioning

confidence: 99%

Exploring the Landscape, Hot Topics, and Trends of Electronic Health Records Literature with Topics Detection and Evolution Analysis

Qian¹,

Ni²,

Gui³

et al. 2021

IJCIS

View full text Add to dashboard Cite

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“…This is higher than most reported rates in Indian literature[ 7 8 ] and comparable to the ones reported in the world literature (40%–60%). [ 10 17 ] Preadolescent children with ADHD have shown to have better adherence than adolescents, which has been attributed to the change seen in adolescents regarding their belief systems, questioning every decision and transitioning to take control over their lives. [ 3 ] Majority of the children (42%) had passive acceptance to their prescribed medications.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 8 ] A recent single medical record study from the west has put adherence rates between 40% and 50% in children availing psychiatric services. [ 10 ] One of the main reasons for such a large variation in nonadherence rates has been due to variations in assessment of adherence, as no standard criteria are available for ADHD. [ 11 ] Studies on adherence have assessed compliance to their respective institute's protocols, number and duration to follow-up, pill refill time, and caregiver surveys, among others.…”

Section: Introductionmentioning

confidence: 99%

Prescription patterns and medication adherence in preadolescent children with attention deficit hyperactivity disorder

Nayak

Nachane

Keshari

et al. 2021

Indian J Psychiatry

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Background: Nonadherence in attention deficit hyperactivity disorder (ADHD) can be as high as 80%, yet studies on adherence to medications in preadolescent children are few. Recent Indian trends in prescription patterns are lacking. Aim: The present study assesses prescription patterns and adherence to medications in preadolescent children with ADHD. Materials and Methods: Fifty children aged 5–12 years with ADHD, who were on medications for at least 6 months, were enrolled. Their sociodemographic factors and prescription details were noted. Vanderbilt ADHD Diagnostic Parents Rating Scale and Compliance Rating Scale were administered. Results: Sixty-two percent of the children had good compliance, whereas 38% showed reluctance. Adherence was better in children with shorter duration of illness, lesser severity, absence of side effects, and stimulant prescription. Non–stimulant-based combination (40%) was more common compared to stimulants (28%), with atomoxetine and risperidone being the most commonly prescribed medications. Conclusions: Adherence to medications in preadolescent children with ADHD is good. Associated factors and implications are discussed.

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“…Our team recently examined the rates and correlates of adherence to stimulant treatment in children with ADHD using data from electronic medical records (EMR) from a large healthcare organization (Biederman et al, 2019a). Of the 2200 pediatric patients identified in the EMR with stimulant prescriptions, only 46% refilled their prescriptions within a time frame to be considered consistently medicated, indicating that adherence to stimulant treatment for children with ADHD was poor.…”

Section: Introductionmentioning

confidence: 99%

“…The main aim of this study was to assess the effectiveness of a novel text messaging-based ADHD-centric intervention aimed at improving adherence to stimulant medications in pediatric ADHD in the primary care setting. We targeted the primary care setting based on our findings documenting that while adherence was poor in all settings, it was particularly poor in the primary care setting (Biederman et al, 2019a). For comparison purposes, we also included a subsample of psychiatrically referred subjects.…”

Section: Introductionmentioning

confidence: 99%

An innovative SMS intervention to improve adherence to stimulants in children with ADHD: Preliminary findings

et al. 2020

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Background: Although large datasets document that stimulants decrease the risk for many adverse ADHD-associated outcomes, compliance with stimulants remains poor. Aims: This study examined the effectiveness of a novel ADHD-centric text messaging-based intervention aimed to improve adherence to stimulant medications in children with ADHD. Methods: Subjects were 87 children aged 6–12, who were prescribed a stimulant medication for ADHD treatment. Prescribers gave permission to contact their patients for participation in the study. Subjects were primarily from the primary care setting with a subsample of psychiatrically referred subjects for comparison. Age- and sex-matched comparators were identified (3:1) from the same pool of prescriber-approved subjects that did not participate. Timely prescription refills (within 37 days) were determined from prescription dates documented in patients’ electronic medical record. Results: Eighty-five percent of SMS intervention patients refilled their prescriptions in a timely manner compared with 62% of patients receiving treatment as usual (OR = 3.46, 95% CI: 1.82, 6.58; p < 0.001). The number needed to treat statistic was computed as five, meaning for every five patients who receive the SMS intervention, we can keep one adherent to their stimulant treatment. Conclusions: These preliminary findings support the potential utility of a readily accessible technology to improve the poor rate of adherence to stimulant treatment in children with ADHD. To the best of our knowledge, this study is the first digital health intervention aimed at improving adherence to stimulant medication for children with ADHD. These results support the need for further examination of this technology through more definitive randomized clinical trials.

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Evidence of Low Adherence to Stimulant Medication Among Children and Youths With ADHD: An Electronic Health Records Study

Cited by 40 publications

References 46 publications

Exploring the Landscape, Hot Topics, and Trends of Electronic Health Records Literature with Topics Detection and Evolution Analysis

Exploring the Landscape, Hot Topics, and Trends of Electronic Health Records Literature with Topics Detection and Evolution Analysis

Prescription patterns and medication adherence in preadolescent children with attention deficit hyperactivity disorder

An innovative SMS intervention to improve adherence to stimulants in children with ADHD: Preliminary findings

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