Evidence of locally acquired spotted fever group rickettsioses in Southeast Texas, 2008–2016

Erickson, Timothy A.; Gunter, Sarah M.; Starke, Jeffrey A.; Murray, Kristy O.

doi:10.1111/zph.12518

Cited by 2 publications

(1 citation statement)

References 9 publications

(13 reference statements)

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“…Researchers of recent studies have shown more infections with Rickettsia as well as confirmed autochthonous transmission of spotted fever group rickettsioses in Houston. 25,26 In these studies, relatively few instances of Rickettsia infections were followed with convalescent serological testing, although in every case in which convalescent testing was conducted, fourfold conversion confirming infection occurred. 27 For this reason we chose to include these infections as causes of encephalitis.…”

Section: Discussionmentioning

confidence: 99%

Infectious and Autoimmune Causes of Encephalitis in Children

et al. 2020

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BACKGROUND AND OBJECTIVES: Encephalitis can result in neurologic morbidity and mortality in children. Newly recognized infectious and noninfectious causes of encephalitis have become increasingly important over the past decade. METHODS:We retrospectively reviewed medical records from pediatric patients in Houston diagnosed with encephalitis in both an urban and rural catchment area between 2010 and 2017. We conducted an investigation to understand the etiology, clinical characteristics, and diagnostic testing practices in this population. RESULTS:We evaluated 231 patients who met the case definition of encephalitis, among which 42% had no recognized etiology. Among those with an identified etiology, the most common were infectious (73; 31%), including viral (n = 51; 22%), with the most frequent being West Nile virus (WNV; n = 12), and bacterial (n = 19; 8%), with the most frequent being Bartonella henselae (n = 7). Among cases of autoimmune encephalitis (n = 60; 26%), the most frequent cause was anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (n = 31). Autoimmune causes were seen more commonly in female (P , .01) patients. Testing for herpes simplex virus and enterovirus was nearly universal; testing for anti-NMDAR encephalitis, WNV, and Bartonella was less common.CONCLUSIONS: WNV was the most common infectious cause of encephalitis in our pediatric population despite lower testing frequency for WNV than herpes simplex virus or enterovirus. Increasing testing for anti-NMDAR encephalitis resulted in frequent identification of cases. Increased awareness and testing for WNV and Bartonella would likely result in more identified causes of pediatric encephalitis. Earlier etiologic diagnosis of encephalitides may lead to improve clinical outcomes.WHAT'S KNOWN ON THIS SUBJECT: Pediatric encephalitides are often severe and lack an identified etiology. Newly recognized viruses and autoimmune causes are considered to be important, but no large recent studies have been conducted to assess their exact role in children. WHAT THIS STUDY ADDS:We found more encephalitides caused by West Nile virus, Bartonella, and autoimmune disease, despite these conditions being tested for less frequently. Testing for these conditions will improve our understanding of etiology and pathogenesis and may improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Infectious and Autoimmune Causes of Encephalitis in Children

et al. 2020

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Features of the Epidemiological Situation on Siberian Tick Typhus and other Tick-Borne Ricketsioses in the Russian Federation, Prognosis for 2019

Рудаков

Шпынов

Trankvilevsky

et al. 2019

Problemy Osobo Opasnykh Infektsii

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The review presents an analysis of the epidemic situation on infections of rickettsial etiology, the causative agents of which are transmitted by Ixodidae ticks in the territory of the Russian Federation. The data obtained through molecular-biological verification allow to unite under the name of “tick-borne ricketsioses” a group of infections caused by R. sibirica subsp. sibirica, R. conorii, R. heilongjiangensis and other species of rickettsiae circulating in natural foci of various regions of Russia. Cases of tick-borne rickettsioses in Siberia and the Far East, caused by various species of rickettsiae, are registered under the name of “Siberian tick-borne typhus” due to the lack of available methods of differential laboratory diagnostics. The paper presents the assessment of the incidence of Siberian tick-borne typhus, indicating not only the varying degrees of epidemic hazard of endemic regions, but also changes in the distribution of risk areas, including the identification of new, epidemically significant foci. In accordance with the risk-oriented approach to prophylaxis, forecasting of epidemic situation on tick-borne rickettsioses was given and differentiation of the endemic territories of the Russian Federation as regards Siberian tick-borne typhus was carried out with distinguishing of epidemiological zones of low, medium, above average, high and very high risk of population infection.

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Evidence of locally acquired spotted fever group rickettsioses in Southeast Texas, 2008–2016

Cited by 2 publications

References 9 publications

Infectious and Autoimmune Causes of Encephalitis in Children

Infectious and Autoimmune Causes of Encephalitis in Children

Features of the Epidemiological Situation on Siberian Tick Typhus and other Tick-Borne Ricketsioses in the Russian Federation, Prognosis for 2019

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