Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis

Zermiani, Angela Pierina dos Reis Buzzo; Soares, Ana Luiza Pelissari Peçanha de Paula; Moura, Bárbara Leticia da Silva Guedes de; Miguel, Edson Roberto Arpini; Lopes, Luciana Dias Ghiraldi; Santana, N.; Santos, Thaís da Silva; Demarchi, Izabel Galhardo; Teixeira, Jorge Juarez Vieira

doi:10.1016/j.ctim.2021.102781

Cited by 11 publications

(3 citation statements)

References 54 publications

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“…A systematic review of five RCTs (271 infants) evaluating the effect of probiotics (various strains) on crying revealed inconsistent results depending on the probiotic species and feeding method [ 15 16 ]. Another systematic review and meta-analysis pooling results from eight RCTs concluded that the administration of L. reuteri DSM 17938 can be considered for IC [ 17 ]. Few physicians discontinued breastfeeding to resolve IC.…”

Section: Discussionmentioning

confidence: 99%

Infantile Colic: A Survey of Physicians in Pakistan

Jalal,

Mehdi,

Akber

et al. 2024

Pediatr Gastroenterol Hepatol Nutr

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Purpose Infantile colic diagnostic criteria were established by Rome IV. A universally accepted management remains to be established. We aimed to evaluate diagnostic criteria, management strategies, and perceived regional prevalence of infantile colic in Pakistan, as well as its effect on physicians and parents. Methods A questionnaire was distributed amongst 1,256 physicians. Results We received 800 replies. Wessel and Rome IV criteria were used by most physicians for diagnosis; however, the response “any infant who cries a lot” was selected by older physicians (48% of those over 60 years), physicians in rural areas (32%), physicians practicing in private clinics (27%), and general physicians (30%). Estimated prevalence of infantile colic ranges from 21–40%. Reassurance was the most widely recommended management strategy followed by herbal teas (51%), switching to a different formula (49%), probiotics (28%) and antibiotics (26%), discontinuation of breastfeeding (14%), elimination of dairy products from the breastfeeding mothers’ diet (6%), and the administration of colic drops (1%). Most physicians considered the negative impact of colic on their personal lives and the parents as mild-to-moderate. Notably, 38% of percent of physicians routinely screened for maternal depression, and 45% of physicians were aware of the association between infantile colic and shaken baby syndrome. Conclusion Most physicians in Pakistan diagnose and manage infantile colic according to the established guidelines. However, the guidelines pertaining to treatment planning are not followed. Educational efforts directed toward general physicians and doctors practicing in rural areas and clinics must be implemented to avoid unnecessary testing and treatment burden.

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Section: Discussionmentioning

confidence: 99%

Infantile Colic: A Survey of Physicians in Pakistan

Jalal,

Mehdi,

Akber

et al. 2024

Pediatr Gastroenterol Hepatol Nutr

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“…Some studies have suggested that probiotics are more effective in infants who are breastfed rather than formula. 41 – 43 Given such findings and overall benefits of breast milk, every effort should be made to encourage breastfeeding and to express breast milk during hospital stay and after discharge in these infants.…”

Section: Discussionmentioning

confidence: 99%

Probiotic supplementation in neonates with congenital gastrointestinal surgical conditions: a pilot randomised controlled trial

et al. 2022

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Objective To evaluate whether probiotic supplementation attenuates gut-dysbiosis in neonates with congenital gastrointestinal surgical conditions (CGISC). Methods Sixty-one neonates (≥35 weeks gestation) with CGISC were randomised to receive daily supplementation with a triple-strain bifidobacterial probiotic ( n = 30) or placebo ( n = 31) until discharge. Stool microbiota was analysed using 16S ribosomal RNA gene sequencing on samples collected before (T1), 1 week (T2), and 2 weeks (T3) after supplementation and before discharge (T4). The primary outcome was the sum of the relative abundance of potentially pathogenic families of Clostridiaceae , Enterobacteriaceae , Enterococcaceae , Pseudomonaceae , Staphylococcaeae , Streptococcaceae , and Yersiniaceae at T3. Results The median gestational age [38 weeks (IQR: 37.1–38.9)] was similar in both groups. The probiotic group had lower rates of caesarean deliveries (40% versus 70%, p = 0.02). The relative abundance of potentially pathogenic families was lower in the probiotic group compared to placebo at T3 [(median: 50.4 (IQR: 26.6–67.6) versus 67.1 (IQR: 50.9–96.2); p = 0.04). Relative abundance of Bifidobacteriaceae was higher in the probiotic group at T3 [(median: 39.8 (IQR: 24.9–52.1) versus 0.03 (IQR 0.02–2.1); p < 0.001). Stratified analysis continued to show a higher abundance of Bifidobacteriaceae in the probiotic group, irrespective of the mode of delivery. Conclusions Probiotic supplementation attenuated gut dysbiosis in neonates with CGISC. Trial registration http://www.anzctr.org.au (ACTRN12617001401347). Impact Probiotic supplementation attenuates gut dysbiosis and improves stool short-chain fatty acid levels in neonates with congenital gastrointestinal surgical conditions. This is the second pilot RCT of probiotic supplementation in neonates with congenital gastrointestinal conditions. These findings will pave the way for conducting multicentre RCTs in this area.

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“…No significant differences were found in the studies conducted in Poland by Urbanska et al [125] and Wanke et al [126], using Limosilactobacillus reuteri DSM 17,938 for preventing nosocomial diarrhoea in children, including rotavirus infection. Limosilactobacillus reuteri DSM 17,938 has otherwise shown to be effective in the prevention and treatment of infantile colic and regurgitation and gastrointestinal disorders [127][128][129].…”

Section: Studies With No Antiviral Effect Of Probiotics Against Rotav...mentioning

confidence: 99%

The Efficacy of Probiotics as Antiviral Agents for the Treatment of Rotavirus Gastrointestinal Infections in Children: An Updated Overview of Literature

2022

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Enteric viruses, including the rotavirus, norovirus, and adenoviruses, are the most common cause of acute gastroenteritis. The rotavirus disease is especially prevalent among children, and studies over the past decade have revealed complex interactions between rotaviruses and the gut microbiota. One way to treat and prevent dysbiosis is the use of probiotics as an antiviral agent. This review focuses on the latest scientific evidence on the antiviral properties of probiotics against rotavirus gastroenteric infections in children. A total of 19 studies exhibited a statistically significant antiviral effect of probiotics. The main probiotics that were effective were Saccharomyces cerevisiae var. boulardii, Lacticaseibacillus rhamnosus GG, and various multi-strain probiotics. The underlying mechanism of the probiotics against rotavirus gastroenteric infections in children included immune enhancement and modulation of intestinal microbiota leading to shortening of diarrhoea. However, several clinical studies also found no significant difference in the probiotic group compared to the placebo group even though well-known strains were used, thus showing the importance of correct dosage, duration of treatment, quality of probiotics and the possible influence of other factors, such as the production process of probiotics and the influence of immunisation on the effect of probiotics. Therefore, more robust, well-designed clinical studies addressing all factors are warranted.

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Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis

Cited by 11 publications

References 54 publications

Infantile Colic: A Survey of Physicians in Pakistan

Infantile Colic: A Survey of Physicians in Pakistan

Probiotic supplementation in neonates with congenital gastrointestinal surgical conditions: a pilot randomised controlled trial

The Efficacy of Probiotics as Antiviral Agents for the Treatment of Rotavirus Gastrointestinal Infections in Children: An Updated Overview of Literature

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