Evidence of Intragenic Recombination in African Horse Sickness Virus

Ngoveni, Harry; Schalkwyk, Antoinette van; Koekemoer, Otto

doi:10.3390/v11070654

Cited by 10 publications

(14 citation statements)

References 45 publications

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“…This is indicated by detections of reassortment and intragenic recombination in eight, respectively seven, of nine LEAV strains. This is all the more clear for orbiviruses with great antigenic diversity like BTV [57,66,67] and AHSV [68], but also for orthoreoviruses [69][70][71] and rotaviruses [72].…”

Section: Discussionmentioning

confidence: 99%

Letea Virus: Comparative Genomics and Phylogenetic Analysis of a Novel Reassortant Orbivirus Discovered in Grass Snakes (Natrix natrix)

Tomazatos

Marschang

Maranda

et al. 2020

Viruses

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The discovery and characterization of novel arthropod-borne viruses provide valuable information on their genetic diversity, ecology, evolution and potential to threaten animal or public health. Arbovirus surveillance is not conducted regularly in Romania, being particularly very scarce in the remote and diverse areas like the Danube Delta. Here we describe the detection and genetic characterization of a novel orbivirus (Reoviridae: Orbivirus) designated as Letea virus, which was found in grass snakes (Natrix natrix) during a metagenomic and metatranscriptomic survey conducted between 2014 and 2017. This virus is the first orbivirus discovered in reptiles. Phylogenetic analyses placed Letea virus as a highly divergent species in the Culicoides-/sand fly-borne orbivirus clade. Gene reassortment and intragenic recombination were detected in the majority of the nine Letea virus strains obtained, implying that these mechanisms play important roles in the evolution and diversification of the virus. However, the screening of arthropods, including Culicoides biting midges collected within the same surveillance program, tested negative for Letea virus infection and could not confirm the arthropod vector of the virus. The study provided complete genome sequences for nine Letea virus strains and new information about orbivirus diversity, host range, ecology and evolution. The phylogenetic associations warrant further screening of arthropods, as well as sustained surveillance efforts for elucidation of Letea virus natural cycle and possible implications for animal and human health.

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Section: Discussionmentioning

confidence: 99%

Letea Virus: Comparative Genomics and Phylogenetic Analysis of a Novel Reassortant Orbivirus Discovered in Grass Snakes (Natrix natrix)

Tomazatos

Marschang

Maranda

et al. 2020

Viruses

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“…NS4 has recently been shown to be an important virulence factor, by disrupting JAK-STAT signaling in the innate immune and antiviral response of the host animal [11]. Genome reassortment and recombination is seen in AHSV and plays an important role in the evolution of orbiviruses [12,14].…”

Section: African Horse Sicknessmentioning

confidence: 99%

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

Clemmons

Alfson

Dutton

2021

Animals

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Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highly contagious or transmissible, epidemic diseases, with the potential to spread rapidly across the globe and the potential to cause substantial socioeconomic and public health consequences. Transboundary animal diseases can threaten the global food supply, reduce the availability of non-food animal products, or cause the loss of human productivity or life. Further, TADs result in socioeconomic consequences from costs of control or preventative measures, and from trade restrictions. A greater understanding of the transmission, spread, and pathogenesis of these diseases is required. Further work is also needed to improve the efficacy and cost of both diagnostics and vaccines. This review aims to give a broad overview of 17 TADs, providing researchers and veterinarians with a current, succinct resource of salient details regarding these significant diseases. For each disease, we provide a synopsis of the disease and its status, species and geographic areas affected, a summary of in vitro or in vivo research models, and when available, information regarding prevention or treatment.

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“…Reassortant and recombination are very important mechanism for virus evolution to escape host immune surveillance, adapt to changing environment, expand host range and so on, which has been analyzed and reported in most viruses of Reoviridae. The recombination events of BTV was documented in 2010 [10] and Ngoveni gave the evidence of intragenic recombination in AHSV in 2019 [12]. A study by Chen firstly reported on the occurrence of reassortant and recombinant virus between human and pig RVA strains [16].…”

mentioning

confidence: 99%

“…Reassortant and recombination have been confirmed in various RNA viruses and several DNA viruses as a mechanism to adapt to changing environment, expand host range and increase virulence, resulting in the genetic diversity of viruses [7][8][9]. Reassortant and intragenic recombination events have also been reported in most viruses of Reoviridae, such as bluetongue virus (BTV), African horse sickness virus (AHSV), rotaviruses (RVs) and so on [10][11][12]. It is essential for two or more viruses to infect the same host cells, so that their genetic material might be exchanged for reassortment.…”

mentioning

confidence: 99%

Analysis of reassortant and intragenic recombination in Cypovirus

Zhang

Hou

et al. 2020

Virol J

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Cypoviruses (CPVs) are RNA viruses with segmented double-stranded genome and major pathogens of various insects, including economic insects like silkworms and pest insects for agricultural crops and forests. Genome reassortment and recombination are common phenomenon for viruses as a mechanism to expand host range and increase virulence. In the present study, we analyzed the reassortant and recombination events for CPVs. The results showed that two genome segments (S1 and S4) of BmCPV1-YN shared higher nucleotide identity with the corresponding segment of BmCPV1-I while others were all more closely to BmCPV1-SZ, suggesting BmCPV1-YN was originated from reassortant events between BmCPV1-I and BmCPV1-SZ. Recombination analyses revealed that S6 of BmCPV1-YN was a recombinant segment derived from BmCPV1-I and BmCPV1-SZ, and S10 of DpCPV1 was a recombinant segment emerged from BmCPV1-I and LdCPV1. Our findings provide the evidence for the fact that CPVs could undergo reassortant and recombinant events and enrich the knowledge about etiology and molecular epidemiology of CPVs.

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Evidence of Intragenic Recombination in African Horse Sickness Virus

Cited by 10 publications

References 45 publications

Letea Virus: Comparative Genomics and Phylogenetic Analysis of a Novel Reassortant Orbivirus Discovered in Grass Snakes (Natrix natrix)

Letea Virus: Comparative Genomics and Phylogenetic Analysis of a Novel Reassortant Orbivirus Discovered in Grass Snakes (Natrix natrix)

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

Analysis of reassortant and intragenic recombination in Cypovirus

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