Evidence of impaired H-reflex and H-reflex rate-dependent depression in diabetes, prediabetes and obesity: a mini-review

Kababie-Ameo, Rebeca; Gutiérrez-Salmeán, Gabriela; Cuellar, Carlos A.

doi:10.3389/fendo.2023.1206552

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…The H-reflex could monitor disease progression, assess efficacy of treatment, and identify potential deleterious effects of therapies ( Van Alstyne et al, 2021 ). H-reflex tests can be performed in different muscles of both upper and lower limbs in humans ( Zehr, 2002 ) as in patients with diabetic disorders ( Kababie-Ameo et al, 2023 ). Upper limb muscles can be used for Type 2 SMA patients who are wheelchair bound, and lower limb muscles in ambulatory Type 3 SMA patients, as in our study.…”

Section: Discussionmentioning

confidence: 99%

Dysfunction of proprioceptive sensory synapses is a pathogenic event and therapeutic target in mice and humans with spinal muscular atrophy

Simon,

Delestree,

Montes

et al. 2024

Preprint

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Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by a varying degree of severity that correlates with the reduction of SMN protein levels. Motor neuron degeneration and skeletal muscle atrophy are hallmarks of SMA, but it is unknown whether other mechanisms contribute to the spectrum of clinical phenotypes. Here, through a combination of physiological and morphological studies in mouse models and SMA patients, we identify dysfunction and loss of proprioceptive sensory synapses as key signatures of SMA pathology. We demonstrate that SMA patients exhibit impaired proprioception, and their proprioceptive sensory synapses are dysfunctional as measured by the neurophysiological test of the Hoffmann reflex (H-reflex). We further show that loss of excitatory afferent synapses and altered potassium channel expression in SMA motor neurons are conserved pathogenic events found in both severely affected patients and mouse models. Lastly, we report that improved motor function and fatigability in ambulatory SMA patients and mouse models treated with SMN-inducing drugs correlate with increased function of sensory-motor circuits that can be accurately captured by the H-reflex assay. Thus, sensory synaptic dysfunction is a clinically relevant event in SMA, and the H-reflex is a suitable assay to monitor disease progression and treatment efficacy of motor circuit pathology.One-sentence summarySensory-motor circuit dysfunction involving impairment of proprioceptive synapses on motor neurons is a conserved pathogenic event and therapeutic target across animal models and humans with spinal muscular atrophy.

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Section: Discussionmentioning

confidence: 99%