Evidence of high sugar intake, and low fibre and mineral intake, in the gluten‐free diet

Wild, Dianne; Robins, Gerry; Burley, Victoria J.; Howdle, P D

doi:10.1111/j.1365-2036.2010.04386.x

Cited by 249 publications

(269 citation statements)

References 15 publications

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“…This is likely due to the fact that intake of these nutrients did not significantly increase on the GFD and remained persistently low, a finding that is supported within the literature, particularly in Canada where intakes of vitamin D are generally low in healthy children and adolescents (El Hayek et al, 2010;Ohlund et al, 2010;Wild et al, 2010;Mark et al, 2011). Although a few children were taking a vitamin supplement (n ¼ 5), these were consumed on an ad hoc basis, and likely did not contribute sufficiently to overall vitamin D/calcium nutriture and bone health.…”

Section: Discussionsupporting

confidence: 66%

Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease

2011

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Background/Objectives: Children with celiac disease (CD) are at risk for decreased bone mineral density (BMD) because of fat-soluble vitamin malabsorption, inflammation and/or under-nutrition. The study objective was to determine the interrelationships between vitamin K/D status and lifestyle variables on BMD in children and adolescents with CD at diagnosis and after 1 year on the gluten-free diet (GFD). Subjects/Methods: Children and adolescents aged 3-17 years with biopsy proven CD at diagnosis and after 1 year on the GFD were studied. BMD was measured using dual-energy X-ray absorptiometry. Relevant variables included: anthropometrics, vitamin D/K status, diet, physical activity and sunlight exposure. Results: Whole-body and lumbar-spine BMD-z scores were low (pÀ1) at diagnosis (10-20%) and after 1 year (30-32%) in the children, independent of symptoms. Whole-body BMD-z scores (À0.55±0.7 versus 0.72±1.5) and serum levels of 25(OH) vitamin D (90.3 ± 24.8 versus 70.5 ± 19.8 nmol/l) were significantly lower in older children (410 years) when compared with younger children (p10 years) (Po0.001). Forty-three percent had suboptimal vitamin D status (25(OH)-vitamin D o75 nmol/l) at diagnosis; resolving in nearly half after 1 year on the GFD. Twenty-five percent had suboptimal vitamin K status at diagnosis; all resolved after 1 year. Conclusions: Children and adolescents with CD are at risk for suboptimal bone health at time of diagnosis and after 1 year on GFD; likely due in part to suboptimal vitamin D/K status. Therapeutic strategies aimed at optimizing vitamin K/D intake may contribute to improved BMD in children with CD.

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Section: Discussionsupporting

confidence: 66%

Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease

2011

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“…Conversely, other authors showed significantly lower energy (6,16) and fibre intakes (17,18) , but higher intakes of total and saturated fat (16) in the diet of coeliac patients compared with healthy controls. In relation to micronutrient intakes, the majority of studies showed lower levels of folate, niacin, vitamin B 12 , vitamin E, vitamin A, P, Ca, Zn and Se in coeliac individuals than in controls (8,9,(17)(18)(19)(20) . As a consequence, despite the relatively abundant literature on the dietary habits of coeliac individuals, it is still difficult to draw a conclusion on the nutritional adequacy of the GF diet.…”

Section: Discussionmentioning

confidence: 81%

The development of a composition database of gluten-free products

Mazzeo

Cauzzi

Brighenti

et al. 2014

Public Health Nutr.

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Objective: To develop a composition database of a number of foods representative of different categories of gluten-free products in the Italian diet. Design: The database was built using the nutritional composition of the products, taking into consideration both the composition of the ingredients and the nutritional information reported on the product label. Setting: The nutrient composition of each ingredient was obtained from two Italian databases (European Institute of Oncology and the National Institute for Food and Nutrition). Subjects: The study developed a food composition database including a total of sixty foods representative of different categories of gluten-free products sold on the Italian market. The composition of the products included in the database is given in terms of quantity of macro-and micronutrients per 100 g of product as sold, and includes the full range of nutrient data present in traditional databases of gluten-containing foods.

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“…[7] Most importantly, this protein is also reported to bring in severe intestinal damage. [8] Literature survey confirms the presence of excess repeats of proline and glutamine residues in them. [9,10] Their partial digestion with gastric and pancreatic enzyme provides prolline and glutamate rich stable and resistant short motifs which exhibits intolerance in Homo sapiens (PFPQPQLPY,PQPQLPYPQ(threecopies);PYPQPQLPY(twocopies); 33mer (LQLQPFPQPQLPY PQPQLPYPQPQLPYPQPQPF).…”

Section: Introductionmentioning

confidence: 90%

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2017

RJLBPCS

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Introduction: Gliadin intake causes celiac disease in selected population of Homo sapiens. Short motifs in α/β gliadin wheat protein were behind this food related disorder. Materials and Methods: Fold based template selection software GenTHREADER was considered for template selection and Modeller software was used for modelling wheat gliadin. T-Coffee software was used for the sequence alignment. Finally, antigenic region was identified. Results: Through in silico based study, we identified a novel motif 'HNxxH' in α/β gliadin wheat gliadin in C-terminal region which shows striking resemblance with the helical zinc binding motif 'HExxH' of metalloproteases.Interestingly, this short segment of gliadin is reported to be both an antigen and toxin which aligns well with the zinc binding site of the metalloproteases. Sequence analysis reports a spatial arrangement of the first two histidine residues from predicted motif of gliadin very much similar to the arrangement exhibited by the histidine residues in the selected metalloproteases like Astacin, Matrix metalloproteases and Predicted metal-dependent hydrolase. Additionally, glutamic acid, glycine and histidine from 2 nd , 8 th and 11 th position were substituted by asparagine, isoleucine and glutamine, respectively in this domain. Conclusion: A wet lab based analysis could certainly confirm the evolutionary relatedness of both gliadin and metalloproteases from sequential, structural and immunological perspective.

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Evidence of high sugar intake, and low fibre and mineral intake, in the gluten‐free diet

Abstract: SUMMARY BackgroundThe only therapy for coeliac disease (CD) is a long-term gluten-free diet (GFD). Little is known about the detailed composition of such a diet.

Cited by 249 publications

References 15 publications

Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease

Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease

The development of a composition database of gluten-free products

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