Abstract. -Spin-dependent transport properties of magnetic nanostructures have been investigated by means of magneto-thermogalvanic voltage measurements: the ac voltage response to an ac temperature oscillation is measured for various magnetic nanostructures under dc current. The samples studied include Co/Cu multilayered nanowires, homogeneous Ni nanowires and cobalt clusters embedded in copper films. The magnetic field dependence of this signal is always larger than the magneto-resistance (MR) and may be anisotropic even when the MR is not. A thermodynamic argument introduces spin mixing as the main process measured by this novel thermoelectric measurement technique. This effect is not observed in magnetite as can be justified by the absence of an accessible second spin channel.Spin-dependent transport in magnetic materials is one of the key ingredients of spintronics and has already demonstrated its importance in effects like Giant magnetoresistance (GMR) [1,2]. Valet and Fert described this effect with the help of a two-current model [3], neglecting the reduction of GMR due to spin mixing processes, on the basis that they were negligible. In the present paper, we investigate these spin mixing effects by means of a novel thermoelectric experiment, called magneto-thermogalvanic voltage (MTGV). We have applied this measurement technique to various magnetic systems, like nanowires (homogenous and multilayered) and films (granular structures). Our data show that the observed magnetic field response must arise from a mechanism distinct from GMR. A thermodynamic approach, based on transport matrix for a magnetic medium [4], suggests that MTGV depends on spin mixing effects.