Evidence of Heritable Determinants of Decompression Sickness in Rats

Lautridou, Jacky; Buzzacott, Peter; Belhomme, Marc; Dugrenot, Emmanuel; Lafère, Pierre; Balestra, Costantino; Guerrero, François

doi:10.1249/mss.0000000000001385

Cited by 15 publications

(24 citation statements)

References 33 publications

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“…Also, as our results are in line with different study populations, collection methods and sample techniques, this tends to confirm that our results are not subject to selection bias or natural variation. Although male and female physiology could respond differently to hyperbaric hyperoxic conditions, we choose to include both sexes in this study to increase its clinical relevance (van Ooij et al, 2011; Lautridou et al, 2017). However, in a large study by Blanchet et al (2017) no significant effect of age, sex or BMI on exhaled breath profiles was found.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis

et al. 2019

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Section: Strengths and Limitationsmentioning

confidence: 99%

Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis

et al. 2019

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“…Also, dry diving affects cardiovascular function to a lesser degree than water immersion does ( Gaustad et al, 2010 ), and diving-naïve rats, as the ones in the present study, display different vascular responses than rats that have been exposed to diving regularly ( Berenji Ardestani et al, 2019 , 2020 ). Finally, epidemiological data from human divers as well as pre-clinical models show that DCS development is dictated by more factors than bubbles ( Cialoni et al, 2017 ; Lautridou et al, 2017 ). Additionally, as CO and SV were still falling at the time our experiment was terminated, we do not know how large the final decrease might be had the experiment been extended.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cold Decompression on Hemodynamic Function and Decompression Sickness Risk in a Dry Diving Rat Model

et al. 2021

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Background: Diving in cold water is thought to increase the risk of decompression sickness (DCS), especially if the diver is cold during decompression. In this study, we investigated hemodynamic function and DCS risk in an animal model, where cold decompression was followed by rewarming at the surface.Methods: Nine female Sprague Dawley rats had pressure-volume catheters inserted into their left heart ventricle and femoral artery before they were exposed to dry air dives in which their core temperature was normothermic during the bottom phase, cold (35°C) during decompression, and normothermic after the dive. Data from an earlier study were used as controls. The rats were compressed in air to 600kPa, maintained at pressure for 45min, and decompressed at 50kPa/min. Hemodynamic data were recorded before, during, and 60min after decompression. Venous gas bubbles were recorded in the right heart ventricle and pulmonary artery for 60min after the dive.Results and Conclusion: During decompression, cardiac output (CO), and stroke volume (SV) decreased equally in cold rats and controls. CO and SV were temporarily re-established at the surface, before falling again in the cold rats. There was no difference in post-dive venous bubble grades. However, as the post-dive fall in CO and SV could be a sign of gas emboli obstructing the pulmonary circulation, we cannot conclude whether the DCS risk was increased. More sensitive bubble detection methods are needed to elucidate this point.

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“…inheritability of Dcs protection is also considered in murines. 32 experimental studies with rats have shown that a single session of treadmill exercise, 20 hours before diving, reduced bubble levels and also mortality in a dramatic way. 33 in human divers also, pre-dive exercise has been shown influential 34 and, depending on the timing and intensity, seems to reduce or augment Vge counts.…”

Section: On the Bubble Sidementioning

confidence: 99%

Diving physiopathology: the end of certainties? Food for thought

Balestra¹,

Germonpré²,

Rocco³

et al. 2019

Minerva Anestesiol

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our understanding of decompression physiopathology has slowly improved during this last decade and some uncertainties have disappeared. a better understanding of anatomy and functional aspects of patent foramen ovale (PFo) have slowly resulted in a more liberal approach toward the medical fitness to dive for those bearing a PFO. Circulating vascular gas emboli (Vge) are considered the key actors in development of decompression sickness and can be considered as markers of decompression stress indicating induction of pathophysiological processes not necessarily leading to occurrence of disease symptoms. During the last decade, it has appeared possible to influence post-dive VGE by a so-called "preconditioning" as a pre-dive denitrogenation, exercise or some pharmacological agents. in the text we have deeply examined all the scientific evidence about this complicated but challenging theme. Finally, the role of the "normobaric oxygen paradox" has been clarified and it is not surprising that it could be involved in neuroprotection and cardioprotection. However, the best level of inspired oxygen and the exact time frame to achieve optimal effect is still not known. The aim of this paper was to reflect upon the most actual uncertainties and distil out of them a coherent, balanced advice towards the researchers involved in gas-bubbles-related pathologies.

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Evidence of Heritable Determinants of Decompression Sickness in Rats

Abstract: This study offers evidence suggesting the inheritance of DCS resistance. Future research will focus on genetic and physiological comparisons between the initial strain and the new resistant population.

Cited by 15 publications

References 33 publications

Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis

Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis

Effects of Cold Decompression on Hemodynamic Function and Decompression Sickness Risk in a Dry Diving Rat Model

Diving physiopathology: the end of certainties? Food for thought

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