Evidence of genetic regulation of fetal longitudinal growth

Knight, Bridget; Shields, Beverley M.; Turner, Martina; Powell, Roy; Yajnik, Chittaranjan S.; Hattersley, Andrew T.

doi:10.1016/j.earlhumdev.2005.06.003

Cited by 74 publications

(79 citation statements)

References 29 publications

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“…In our study, paternal BMI was correlated with the offspring's early postnatal weight growth contrasting with the absence of association with birthweight. These relationships had already been highlighted in distinct studies [9,24,25] Consequently, paternal and maternal contributions to the offspring's BMI was similar at nine months. Unlike the study from Griffiths et al [9], the mother's BMI did not significantly contribute to the child weight growth velocity in the first three years of life.…”

Section: Discussionmentioning

confidence: 78%

Parental body size and early weight and height growth velocities in their offspring

Botton

Heude

Maccario

et al. 2010

Early Human Development

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Section: Discussionmentioning

confidence: 78%

Parental body size and early weight and height growth velocities in their offspring

Botton

Heude

Maccario

et al. 2010

Early Human Development

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“…The association between maternal length and maternal weight and the offspring's birth weight is in part explained by genetic influences (33,34). It is also known that maternal height and weight have a genetic influence on neuromotor functioning (35).…”

Section: Discussionmentioning

confidence: 99%

Fetal Programming of Infant Neuromotor Development: The Generation R Study

et al. 2010

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ABSTRACT:The objective of the study was to examine whether infant neuromotor development is determined by fetal size and body symmetry in the general population. This study was embedded within the Generation R Study, a population-based cohort in Rotterdam. In 2965 fetuses, growth parameters were measured in mid-pregnancy and late pregnancy. After birth, at age 9 to 15 wks, neuromotor development was assessed with an adapted version of Touwen's Neurodevelopmental Examination. Less optimal neuromotor development was defined as a score in the highest tertile. We found that higher fetal weight was beneficial to infant neurodevelopment. A fetus with a 1-SD score higher weight in mid-pregnancy had an 11% lower risk of less optimal neuromotor development (OR: 0.89; 95% CI: 0.82-0.97). Similarly, a fetus with a 1-SD score larger abdominal-to-head circumference (AC/HC) ratio had a 13% lower risk of less optimal neuromotor development (OR: 0.87; 95% CI: 0.79 -0.96). These associations were also present in late pregnancy. Our findings show that fetal size and body symmetry in pregnancy are associated with infant neuromotor development. These results suggest that differences in infant neuromotor development, a marker of behavioral and cognitive problems, are at least partly caused by processes occurring early in fetal life. (Pediatr Res 67: 132-137, 2010)

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“…However, both maternal and paternal height predicted fetal growth, including head circumference, in a longitudinal growth study of children from Exeter in the United Kingdom (Knight et al, 2005) and in a smaller Chilean sample (Ivanovic et al, 2004).…”

mentioning

confidence: 92%

Heritability of Head Size in Dutch and Australian Twin Families at Ages 0–50 Years

Smit¹,

Luciano

Bartels

et al. 2010

Twin Res Hum Genet

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We assessed the heritability of head circumference, an approximation of brain size, in twin-sib families of different ages. Data from the youngest participants were collected a few weeks after birth and from the oldest participants around age 50 years. In nearly all age groups the largest part of the variation in head circumference was explained by genetic differences. Heritability estimates were 90% in young infants (4 to 5 months), 85–88% in early childhood, 83–87% in adolescence, 75% in young and mid adulthood. In infants younger than 3 months, heritability was very low or absent. Quantitative sex differences in heritability were observed in 15- and 18-year-olds, but there was no evidence for qualitative sex differences, that is, the same genes were expressed in both males and females. Longitudinal analysis of the data between 5, 7, and 18 years of age showed high genetic stability (.78 > RG> .98). These results indicate that head circumference is a highly heritable biometric trait and a valid target for future GWA studies.

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Evidence of genetic regulation of fetal longitudinal growth

Cited by 74 publications

References 29 publications

Parental body size and early weight and height growth velocities in their offspring

Parental body size and early weight and height growth velocities in their offspring

Fetal Programming of Infant Neuromotor Development: The Generation R Study

Heritability of Head Size in Dutch and Australian Twin Families at Ages 0–50 Years

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