Evidence of fetal pulmonary aspiration of intra-amniotic administered surfactant in animal experiment

Illia, Ricardo; Solana, Claudio; Oliveri, Pedro; Toblli, Jorge Eduardo; Imaz, Matias Uranga; Habich, D

doi:10.1515/jpm.2004.066

Cited by 10 publications

(5 citation statements)

References 16 publications

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“…First of all, the experience was conducted in guinea pigs to determine if indeed the surfactant administered intra-amniotic reached the fetal lungs, this was duly substantiated (Figure 1). 64…”

Section: Resultsmentioning

confidence: 99%

Complications of pregnancy: premature rupture of membranes,chorioamnionitis, amnioinfusion, prenatal administration of surfactanct

Illia

Solana

Lobenstein

et al. 2018

IPCB

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It is defined as premature rupture of membranes (RPM) to the leak out of amniotic fluid by genitalia before the onset of labour. 1 It's one of the most frequent in obstetric practice diagnoses and their implications are quite different as this fact occurrence of term or before it. It presents a serious problem because of their difficult prediction and the mechanisms involved are still unknown. We analyzed in this chapter the physiopathology, associated complications and different approaches to treat the picture.

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Section: Resultsmentioning

confidence: 99%

Complications of pregnancy: premature rupture of membranes,chorioamnionitis, amnioinfusion, prenatal administration of surfactanct

Illia

Solana

Lobenstein

et al. 2018

IPCB

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“…A tidal flow of 1.3 to 5 ml of intratracheal fluid has been reported during each respiratory cycle in human fetuses from 28 to 38 weeks' gestation (Kalache 1997). Uptake of intraamniotic radio labelled surfactant by guinea pig and rabbit lungs (7%) has been shown (Galan 1992;Hallman 1997;Illia 2004). Stimulation of fetal respiration increases the lung capture (Illia 2004).…”

Section: How the Intervention Might Workmentioning

confidence: 99%

“…Uptake of intraamniotic radio labelled surfactant by guinea pig and rabbit lungs (7%) has been shown (Galan 1992;Hallman 1997;Illia 2004). Stimulation of fetal respiration increases the lung capture (Illia 2004). Preliminary reports have shown intra-amniotic instillation of surfactant is safe, feasible and potentially e ective (Cosmi 1996a;Cosmi 1996b;Cosmi 1996c;Cosmi 1997;Lisawa 2003;Petrikovsky 1995;Zhang 2002).…”

Section: How the Intervention Might Workmentioning

confidence: 99%

Intra-amniotic surfactant for women at risk of preterm birth for preventing respiratory distress in newborns

Abdel-Latif

Osborn

Challis

2010

Cochrane Database of Systematic Reviews

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“…This confirms that components such as serum, cholesterol, and triglycerides can directly inactivate the surfactant and induce changes in its dynamics [ 108 ]. For this reason, and supported by animal models in lambs and guinea pigs, it has been suggested that surfactant replacement therapy should be accompanied by a drug that allows its mechanism of action to be carried out successfully [ 109 , 110 ].…”

Section: Role Of the Surfactantmentioning

confidence: 99%

Meconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivation

Mota-Rojas

Villanueva-García

Mota-Reyes

et al. 2022

Animals

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Meconium Aspiration Syndrome is a condition that causes respiratory distress in newborns due to occlusion and airway inflammation, and surfactant inactivation by meconium. This condition has been described in animal species such as canids, sheep, cattle, horses, pigs, and marine mammals. In its pathogenesis, the pulmonary epithelium activates a limited inflammatory response initiated by cytokines causing leukocyte chemotaxis, inhibition of phagocytosis, and pathogen destruction. Likewise, cytokines release participates in the apoptosis processes of pneumocytes due to the interaction of angiotensin with cytokines and the caspase pathway. Due to these reactions, the prevalent signs are lung injury, hypoxia, acidosis, and pneumonia with susceptibility to infection. Given the importance of the pathophysiological mechanism of meconium aspiration syndrome, this review aims to discuss the relevance of the syndrome in veterinary medicine. The inflammatory processes caused by meconium aspiration in animal models will be analyzed, and the cellular apoptosis and biochemical processes of pulmonary surfactant inactivation will be discussed.

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Evidence of fetal pulmonary aspiration of intra-amniotic administered surfactant in animal experiment

Abstract: In the present animal model natural surfactant injected intra-amniotically is aspirated into the lungs within one hour.

Cited by 10 publications

References 16 publications

Complications of pregnancy: premature rupture of membranes,chorioamnionitis, amnioinfusion, prenatal administration of surfactanct

Complications of pregnancy: premature rupture of membranes,chorioamnionitis, amnioinfusion, prenatal administration of surfactanct

Intra-amniotic surfactant for women at risk of preterm birth for preventing respiratory distress in newborns

Meconium Aspiration Syndrome in Animal Models: Inflammatory Process, Apoptosis, and Surfactant Inactivation

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