Evidence of decreased GA$Aergic influence on temporal integration in the inferior colliculus following acute noise exposure: a study of evoked potentials in the rat

Szczepaniak, William S.; Møller, Aage R.

doi:10.1016/0304-3940(95)11851-m

Cited by 68 publications

(29 citation statements)

References 19 publications

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“…Many in vivo studies suggest that the modification of inhibitory synapse function is responsible for changes in auditory coding (Kitzes and Semple, 1985;Calford et al, 1993;Szczepaniak and Møller, 1995;McAlpine et al, 1997;Rajan, 1998;Kimura and Eggermont, 1999;Salvi et al, 2000;Wang et al, 2002;Noreña et al, 2003;Chang et al, 2005;Razak et al, 2008). Here, we propose that developmental changes in presynaptic GABA B receptors may affect temporal responses by modulating iSTP of LTS-evoked IPSCs (Fig.…”

Section: Implications For Auditory Processing and Hearing Lossmentioning

confidence: 99%

Presynaptic GABA_BReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity

Takesian¹,

Kotak²,

Sanes³

2010

J. Neurosci.

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Short-term changes in synaptic gain support information processing throughout the CNS, yet we know little about the developmental regulation of such plasticity. Here we report that auditory experience is necessary for the normal maturation of synaptic inhibitory short-term plasticity (iSTP) in the auditory cortex, and that presynaptic GABA B receptors regulate this development. Moderate or severe hearing loss was induced in gerbils, and iSTP was characterized by measuring inhibitory synaptic current amplitudes in response to repetitive stimuli. We reveal a profound developmental shift of iSTP from depressing to facilitating after the onset of hearing. Even moderate hearing loss prevented this shift. This iSTP change was mediated by a specific class of inhibitory interneurons, the lowthreshold spiking cells. Further, using paired recordings, we reveal that presynaptic GABA B receptors at interneuron-pyramidal connections regulate iSTP in an experience-dependent manner. This novel synaptic mechanism may support the emergence of mature temporal processing in the auditory cortex.

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Section: Implications For Auditory Processing and Hearing Lossmentioning

confidence: 99%

Presynaptic GABA_BReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity

Takesian¹,

Kotak²,

Sanes³

2010

J. Neurosci.

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“…In response to superthreshold acoustic stimulation, noise-exposed animals (modest damage to the auditory periphery) show altered evoked responses in the IC and auditory cortex, providing a functional picture suggestive of hyperexcitability (Willott and Lu, 1982;Popelár et al, 1987;Salvi et al, 1990;Gerken et al, 1991;Syka et al, 1994;Szczepaniak and Møller, 1995;Wang et al, 1996;Syka and Rybalko, 2000; Aizawa and Eggermont, 2007). Neurochemical findings in support of these functional changes reveal that damage to the auditory periphery results in a selective down-regulation of normal adult inhibitory GABAergic function in the IC.…”

Section: Inferior Colliculusmentioning

confidence: 99%

“…Neurochemical findings in support of these functional changes reveal that damage to the auditory periphery results in a selective down-regulation of normal adult inhibitory GABAergic function in the IC. Surface-recorded evoked potentials from the IC of noiseexposed rats show reduced sensitivity to bicuculline blockade (Szczepaniak and Møller, 1995). Deafness resulted in decreased GABA release in vivo and decreased numbers of IC neurons showing electrically evoked suppression of unit activity (Bledsoe et al, 1995).…”

mentioning

confidence: 99%

Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system

Caspary

Ling

Turner

et al. 2008

Journal of Experimental Biology

429

355

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SummaryAging and acoustic trauma may result in partial peripheral deafferentation in the central auditory pathway of the mammalian brain. In accord with homeostatic plasticity, loss of sensory input results in a change in pre-and postsynaptic GABAergic and glycinergic inhibitory neurotransmission. As seen in development, age-related changes may be activity dependent. Age-related presynaptic changes in the cochlear nucleus include reduced glycine levels, while in the auditory midbrain and cortex, GABA synthesis and release are altered. Presumably, in response to age-related decreases in presynaptic release of inhibitory neurotransmitters, there are age-related postsynaptic subunit changes in the composition of the glycine (GlyR) and GABA A (GABA A R) receptors. Age-related changes in the subunit makeup of inhibitory pentameric receptor constructs result in altered pharmacological and physiological responses consistent with a net down-regulation of functional inhibition. Age-related functional changes associated with glycine neurotransmission in dorsal cochlear nucleus (DCN) include altered intensity and temporal coding by DCN projection neurons. Loss of synaptic inhibition in the superior olivary complex (SOC) and the inferior colliculus (IC) likely affect the ability of aged animals to localize sounds in their natural environment. Age-related postsynaptic GABA A R changes in IC and primary auditory cortex (A1) involve changes in the subunit makeup of GABA A Rs. In turn, these changes cause age-related changes in the pharmacology and response properties of neurons in IC and A1 circuits, which collectively may affect temporal processing and response reliability. Findings of age-related inhibitory changes within mammalian auditory circuits are similar to age and deafferentation plasticity changes observed in other sensory systems. Although few studies have examined sensory aging in the wild, these age-related changes would likely compromise an animal's ability to avoid predation or to be a successful predator in their natural environment.Key words: aging, central auditory system, GABA A receptor, glycine receptor, inhibitory neurotransmission, plasticity. THE JOURNAL OF EXPERIMENTAL BIOLOGY 1782important in determining the location of sound, echolocation and extracting information from voiced and unvoiced communication signals (Carr et al., 1986;Portfors and Wenstrup, 2001).The complex processing that occurs at the level of the MGB and the A1 is beyond the scope of the present review. Coding in the auditory cortex has been recently reviewed (Wang, 2007;Rauschecker, 2005). As seen in the visual cortex, in the auditory cortex, acoustically complex hierarchical analysis has been described for awake-behaving primates (Rauschecker, 2005;Steinschneider et al., 2008). A1 has been shown to undergo agerelated plastic changes, including down-regulation of inhibitory coding, similar to that observed at lower levels of the auditory pathway and in visual cortex. Similar to age-related changes, activity-dependant changes have be...

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“…The AEPs elicited from the IC were recorded from the ventrocaudal portions of the nucleus. This method of analysis is similar to previous studies from our laboratory and other laboratories that used similar protocols (Hall and Mark, 1967;Szczepaniak and Moller, 1995;Cabral et al, 2009). Peak amplitudes were defined as the maximum amplitude measured between N1 and the end of P1, similar to previous studies from our laboratory Nobre et al, 2003;Cabral et al, 2009).…”

Section: Aepsmentioning

confidence: 58%

Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

Saito¹

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Evidence of decreased GA$Aergic influence on temporal integration in the inferior colliculus following acute noise exposure: a study of evoked potentials in the rat

Cited by 68 publications

References 19 publications

Presynaptic GABA_BReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity

Presynaptic GABA_BReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity

Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system

Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

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Evidence of decreased GA$Aergic influence on temporal integration in the inferior colliculus following acute noise exposure: a study of evoked potentials in the rat

Cited by 68 publications

References 19 publications

Presynaptic GABABReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity

Presynaptic GABABReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity

Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system

Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

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Presynaptic GABA_BReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity

Presynaptic GABA_BReceptors Regulate Experience-Dependent Development of Inhibitory Short-Term Plasticity