Evidence of closely related picobirnavirus strains circulating in humans and pigs in Argentina

Giordano, Miguel O.; Martı́nez, Laura C.; Masachessi, Gisela; Barril, Patricia A.; Ferreyra, Leonardo; Isa, Mar La B.; Valle, Mildre C.; Massari, P.; Nates, Silvia

doi:10.1016/j.jinf.2010.09.031

Cited by 24 publications

(27 citation statements)

References 27 publications

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“…Genogroup I PBVs those were detected and sequenced from pigs in Hungary [4], Venezuela and Argentina [11,41], showed close relationship to human genogroup I PBVs. The PBV strains detected among children in Kolkata, India were reported to be closely related to porcine PBV strains [28,29].…”

Section: Discovery Of Picobirnavirusmentioning

confidence: 95%

“…The primary objective of these environmental studies was to evaluate PBV as an indicator of fecal contamination, the potential health risk of the presence of PBVs in sewages and natural water resources should not be neglected and this finding deserves further investigations. Studies in immuncompromised and immunosuppressed hosts indicated that these viruses might be 'opportunistic pathogens' [38,39,41,42,44,75,80].…”

Section: Discovery Of Picobirnavirusmentioning

confidence: 99%

“…Similarly, PBVs have also been detected as sole pathogens in diarrhoeic animals [9,60,67] and with other known and established enteric pathogens [2,4,83]. They are still classified as 'opportunistic diarrhoeagenic pathogen', since they have been detected from immunocompromised patients and patients with prolonged immunosuppressive treatment who suffered from diarrhoea than non-diarrhoeic controls [18,38,39,41,42,44,75].…”

Section: Introductionmentioning

confidence: 99%

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Animal Picobirnavirus

2014

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Picobirnavirus (PBV) is a small, non-enveloped, bisegmented double-stranded RNA (dsRNA) virus of vertebrate hosts. The name 'Picobirnavirus' derives from the prefix 'pico' (latin for 'small') in reference to the small virion size, plus the prefix 'bi' (latin for 'two') and the word 'RNA' to indicate the nature of the viral genome. The serendipitous discovery of PBV dates back to 1988 from Brazil, when human fecal samples collected during the acute gastroenteritis outbreaks were subjected for routine rotavirus surveillance by polyacrylamide gel electrophoresis (PAGE) and silver straining (S/S). The PAGE gels after silver staining showed a typical 'two RNA band' pattern, and it was identified as Picobirnavirus. Likewise, the feces of wild black-footed pigmy rice rats (Oryzomys nigripes) subjected for PAGE assay by the same research group in Brazil reported the presence of PBV (Pereira et al., J Gen Virol 69:2749-2754. PBVs have been detected in faeces of humans and wide range of animal species with or without diarrhoea, worldwide. The probable role of PBV as either a 'primary diarrhoeal agent' in 'immunocompetent children'; or a 'potential pathogen' in 'immunocompromised individuals' or an 'innocuous virus' in the intestine remains elusive and needs to be investigated despite the numerous reports of the presence of PBV in fecal samples of various species of domestic mammals, wild animals, birds and snakes; our current knowledge of their biology, etiology, pathogenicity or their transmission characteristics remains subtle. This review aims to analyse the veterinary and zoonotic aspects of animal Picobirnavirus infections since its discovery.

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Section: Discovery Of Picobirnavirusmentioning

confidence: 95%

Section: Discovery Of Picobirnavirusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Animal Picobirnavirus

2014

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“…Genogroup I PBVs detected and sequenced from pigs in Hungary [2] and Venezuela and Argentina [5,22], were observed to be closely related to human genogroup I PBVs. These results strongly suggest that PBV strains may circulate in the shared environment where humans and pigs live.…”

mentioning

confidence: 96%

“…Evidence for genetic relatedness was reported between human and animal PBVs or vice versa [2,5,[16][17][18]22] from around the globe. Genogroup I PBVs detected and sequenced from pigs in Hungary [2] and Venezuela and Argentina [5,22], were observed to be closely related to human genogroup I PBVs.…”

mentioning

confidence: 99%

Detection and Molecular Characterization of Porcine Picobirnavirus in Feces of Domestic Pigs from Kolkata, India

et al. 2012

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Picobirnaviruses (PBVs) are small, non-enveloped, 35-41 nm virion with bisegmented double-stranded RNA genome. PBVs are widespread and were detected in feces of humans and a wide variety of animals. Domestic pig, one of the ubiquitous farm animal reported incessant association with a variety of viral zoonoses. The objective of our study is to find out the incidence of PBV infection in healthy domestic pigs. The study was conducted by collecting feces of healthy/asymptomatic pigs from a piggery located in an urban slum at Kolkata, India to detect PBV infections. All the 11 fecal samples were tested by polyacrylamide gel electrophoresis and reverse transcriptionpolymerase chain reaction assay. In this study, we report the first incidence of detection and molecular characterization of porcine PBV (BG-Por-2/2010 and BG-Por-7/ 2010) in feces of domestic pigs from India using the human PBV genogroup I specific primer pair: PicoB25(?) and PicoB43(-). Sequence comparison and phylogenetic analysis of partial RNA-dependent RNA polymerase gene of genome segment 2 revealed genetic relatedness to hitherto reported porcine, murine and human genogroup I PBVs from different geographical regions. This warrants a stringent global surveillance to study the potential zoonotic and emerging PBV infections.

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Picobirnavirus infections: viral persistence and zoonotic potential

Ganesh

Bányai

Martella

et al. 2012

Reviews in Medical Virology

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Picobirnaviruses (PBVs) are small, non-enveloped, bisegmented double-stranded RNA genomic viruses of vertebrate hosts. Since their discovery in the late 1980s in clinical specimens from outbreaks of acute gastroenteritis in children, significant efforts have been made to investigate the role of PBV in diarrheic diseases. PBV has been detected in sporadic episodes of diarrhea as sole pathogen or coinfection as well as in outbreaks of acute gastroenteritis and in immunocompromised patients with diarrhea. However, PBV is frequently detected in non-diarrheic healthy hosts, and prolonged shedding has been observed in some individuals. Of interest, similar patterns of PBV infection have also been observed in pigs and other animal hosts. The increasing amount of PBV sequence data gathered from molecular epidemiological studies has evidenced a great sequence diversity of PBVs in various hosts and environmental samples. Importantly, evidence has been found for genetic relatedness between human and animal PBV strains, suggesting extant crossing points in the ecology and evolution of heterologous PBV strains. At present, no cell culture and animal model exists for PBVs. Well-structured epidemiological studies are still the only alternative to demonstrate the potential etiological role of PBVs in acute gastroenteritis or other diseases. This review aims to analyze the public health aspects of PBV infection, especially its possible association with zoonosis.

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Evidence of closely related picobirnavirus strains circulating in humans and pigs in Argentina

Cited by 24 publications

References 27 publications

Animal Picobirnavirus

Animal Picobirnavirus

Detection and Molecular Characterization of Porcine Picobirnavirus in Feces of Domestic Pigs from Kolkata, India

Picobirnavirus infections: viral persistence and zoonotic potential

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