Evidence of cardiac injury and arrhythmias in dogs with acute kidney injury

Keller, Silvan Peter; Kovačević, Alan; Howard, Judith; Schweighauser, Ariane; Francey, Thierry

doi:10.1111/jsap.12495

Cited by 14 publications

(15 citation statements)

References 55 publications

(81 reference statements)

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“…A recent study has reported similar findings in dogs with acute kidney injury. 13 Accordingly, while primary cardiac disease should always be considered a potential cause of elevated serum troponins, it should not be thought of as the sole possible cause in dogs or cats with renal disease.…”

Section: Discussionmentioning

confidence: 99%

“…The codependence of the cardio–renal axis is well described, its interplay involving especially shared mechanisms related to volume and blood pressure regulation. 9,13 The so-called cardiorenal syndrome has been defined in humans, referring to pathological changes in one system ultimately affecting the other. 9,15 Chronic renocardiac syndrome is defined as ‘chronic abnormalities in renal function leading to cardiac disease’, 16 with causes including activation of the renin–angiotensin–aldosterone system and the sympathetic nervous system following a declining GFR, both of which induce cardiac remodelling with left ventricular hypertrophy (LVH) and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

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Cardiac troponin I in cats with compromised renal function

Langhorn

Jessen

Kloster

et al. 2018

Journal of Feline Medicine and Surgery

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Objectives Cardiac troponins are sensitive and specific markers of myocardial injury. However, their reliability in renal disease has been questioned owing to possible renal involvement in troponin elimination. The primary objective of the present study was to examine whether serum cardiac troponin I is elevated in cats with compromised renal function and no clinically relevant structural cardiac disease. A secondary objective was to examine whether cardiac troponin I is measurable in the urine of cats with normal and compromised renal function. Methods This prospective case-control study included 52 cats (19 with compromised renal function, 19 with primary cardiac disease and 14 healthy controls). For all cats, clinical examination, echocardiography, electrocardiography, blood pressure, complete blood count, biochemistry, serum thyroxine and urinalysis were performed. Cardiac troponin I was measured in the serum and urine of each cat. Results Median (range) serum cardiac troponin I concentrations were 0.052 ng/ml (0.015–0.78 ng/ml) for the renal group, 0.083 ng/ml (0.003–3.27 ng/ml) for the cardiac group and 0.012 ng/ml (0.003–0.14 ng/ml) for the control group. The renal and cardiac groups both had significantly higher serum cardiac troponin I concentrations than the control group, whereas no difference could be detected between the renal and cardiac groups. In the renal group 7/19 cats had measurable urine cardiac troponin I, whereas cardiac troponin I was measurable in the urine of one cat in the cardiac group and two healthy controls. There was no significant correlation between serum and urine cardiac troponin I. Conclusions and relevance Elevated serum cardiac troponin I in cats with compromised renal function may occur without evidence of clinically relevant structural cardiac disease. Moreover, detecting cardiac troponin I in urine is most likely in cats with compromised renal function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cardiac troponin I in cats with compromised renal function

Langhorn

Jessen

Kloster

et al. 2018

Journal of Feline Medicine and Surgery

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“…ОПП является частым внутригоспитальным осложнением различных состояний, связанным с последующим формированием и прогрессированием ХБП, необходимостью применения заместительной почечной терапии, развитием сердечнососудистых и инфекционных осложнений и, в целом, существенным увеличением смертности таких пациентов [1][2][3][4]10]. Заболеваемость ОПП при аллогенной ТГСК является высокой [5-7, 13, 14], однако вопрос о том, насколько развитие ОПП может повлиять на исходы трансплантации, остается открытым из-за ограниченного числа исследований в этой области [15,16].…”

Section: Discussionunclassified

“…По данным N. Shingai и соавт. смертность больных после ТГСК в случае развития острой дисфункции почек в период до приживления трансплантата составила 39,1 % [16]. Нами было показано существенное увеличение смертности больных с ОПП в течение одного года после ТГСК по сравнению со смертностью пациентов без острой дисфункции почек.…”

Section: Discussionunclassified

Acute Kidney Injury Is Independently Associated With All-Cause Mortality Following Hematopoietic Stem Cell Transplantation

Smirnov

Добронравов

Afanasiev

et al. 2018

Nefrologiâ (St.-Peterbg.)

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THE AIM.To determine clinical value of acute kidney injury (AKI) in the setting of allogeneic hematopoietic stem cell transplantation (HSCT) for mortality along postransplant period.PATIENTS ANDMETHODS.Ninety hematopoietic stem cell transplantat (HSCT) recipients (46 males, 44 females) were enrolled in the observational prospective study. Clinical and laboratory data were monitored and assessed 7 days prior to HSCT (week 0), on the posttransplant weeks 1, 2, 3, 4 and 5. AKI was diagnosed according to KDIGO (Kidney Disease Improving Global Outcomes) guidelines. All-cause mortality was registered along 1 year of posttransplant period. AKI associations with death risk were estimated in cumulative survival analysis and Cox multivariate regression models adjusted for other confounders.RESULTS.AKI was diagnosed in 67 (74%) out of 90 patients. The majority of patients (84%) suffered from AKI 1 stage (KDIGO). AKI 2+3 stage (KDIGO) was found in 16% of patients. Renal replacement therapy was used in 4 (6%) patients with AKI. Cumulative survival rate following HSCT reached 75%. 28 deaths (31%) were registered within 1 year following HSCT. AKI was associated with lower cumulative survival following HSCT. AKI was independently associated with the risk of death according to multivariate Cox regression analyses adjusted for other confounders.CONCLUSION. AKI may be considered as a significant clinical predictor of unfavorable allogeneic HSCT outcome, taking into account its independent association with increased risk of posttransplant all-cause mortality.

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“…CvRD K refere-se à disfunção cardiovascular que emana de um processo primário de doença renal (POUCHELON et al, 2015). Dentre as alterações que apresentam potenciais prejudiciais de CvRD K , incluem as anormalidades eletrolíticas, como a hipercalemia e hipocalemia que estão associadas as arritmias cardíacas (POUCHELON et al, 2015;KELLER et al, 2016;BAGSHAW et al, 2018); o uso de medicamentos que são utilizados para o tratamento das doenças cardiovasculares (digoxina, enalapril e atenolol) e que são excretados via renal provocando lesão renal primária, pois quando há disfunção renal e redução da depuração dos fármacos, ocorre o acúmulo das substâncias e sinais de toxicidade farmacológicas, além de desenvolver arritmias, hipotensão e piora da função miocárdica; distúrbios hemodinâmicos, como alterações de volume de fluido, que são sempre anormais em pacientes com doença renal grave e afetam o sistema cardiovascular devido ao baixo débito (POLZIN, 2011).…”

Section: Classificação Das Desordens Do Eixo Cardiovascular-renal Em unclassified

Síndrome Cardiorrenal Em Cães

Mendes¹,

Sousa²,

Carvalho³

2019

Enci Bio

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RESUMO A síndrome cardiorrenal (SCR) ou desordens do eixo cardiovascular-renal (CvRD) é uma afecção que envolve, ao mesmo tempo, o comprometimento renal e cardiovascular. A interação entre esses órgãos é natural e complexa, ambos estão envolvidos em diversos mecanismos vitais para o funcionamento do organismo. A SCR pode ser ocasionada tanto por uma disfunção cardiovascular e renal, em que a disfunção aguda ou crônica em um dos órgãos, pode induzir e perpetuar uma disfunção aguda ou crônica no outro órgão. O diagnóstico da SCR pode ser realizado por meio de biomarcadores renais, cardíacos e exames de imagem, contudo, há a necessidade de identificar quais testes são capazes de detectar precocemente as alterações da doença. O tratamento da SCR é um desafio, pois os pacientes precisam de cuidados que beneficiem os dois sistemas. PALAVRAS-CHAVE: biomarcadores, cardiorrenal, insuficiência cardíaca. CARDIORENAL SYNDROME IN DOGS ABSTRACT A cardiorenal syndrome (SCR) or disorders of the cardiovascular-renal axis (CvRD) is a disease that involves at the same time, renal and cardiovascular impairment. A between between body is natural and complex, both are or serve in organs devices to the working of the organization. SCR can be caused by a cardiovascular and renal dysfunction, that is, an acute or chronic dysfunction in some organ, can induce and perpetuate an acute or chronic dysfunction in the other organ. The diagnosis of SCR can be made by means of renal, cardiac and imaging biomarkers, although all the symptoms are capable of detecting early changes in the disease. Treatment of SCR is a challenge because patients need care that benefits both systems.

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Evidence of cardiac injury and arrhythmias in dogs with acute kidney injury

Abstract: Acute kidney injury seems to be associated with cardiac injury and arrhythmias in dogs. The data do not indicate a cardiac cause of poor outcome in dogs with increased number of ventricular premature complexes but the association may reflect the severity of disease.

Cited by 14 publications

References 55 publications

Cardiac troponin I in cats with compromised renal function

Cardiac troponin I in cats with compromised renal function

Acute Kidney Injury Is Independently Associated With All-Cause Mortality Following Hematopoietic Stem Cell Transplantation

Síndrome Cardiorrenal Em Cães

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