Evidence of anti-inflammatory and antinociceptive activities of Plinia edulis leaf infusion

Azevedo, Lcp; Silva, Simone Maria da; Navarro, Lucas B.; Yamaguchi, Lydia F.; Nascimento, Carlos G.O.; Soncini, Roseli; Ishikawa, Tati

doi:10.1016/j.jep.2016.07.001

Cited by 25 publications

(17 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Grouping and administration method of Kunming male mice (total = 64, 8 per group) are the same as “2.6.1” item. After 30 min of the last treatment, the left hind paw of each mouse was injected subcutaneously with 50 μl carrageenan (1%, w/v saline) ( Passos et al, 2007 ; Azevedo et al, 2016 ). Paw volume was measured using a digital plethysmometer (Ugo Basile, Co., Italy) at 0th, 1st, 2nd, 3rd, 4th, and 5th h after treatment ( Vittalrao et al, 2011 ).…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory and Analgesic Effects of Polygonum orientale L. Extracts

et al. 2017

View full text Add to dashboard Cite

Background and Purpose: Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, is a Traditional Chinese Medicinal and has long been used for rheumatic arthralgia and rheumatoid arthritis. However, no pharmacological and mechanism study to confirm these clinic effects have been published. In this investigation, the anti-inflammatory, analgesic effects and representative active ingredient compounds of P. orientale have been studied.Methods: Dried small pieces of the stems and leaves of P. orientale were decocted with water and partitioned successively to obtain ethyl acetate and ethyl ether extract of P. orientale (POEa and POEe). Chemical compositions of them were analyzed by UPLC-Q-Exactive HRMS. Anti-inflammatory and analgesic effects of POEa and POEe were evaluated using xylene induced ear edema, carrageenan induced paw edema, Freunds’ complete adjuvant induced arthritis, and formaldehyde induced pain in rat. Their mechanisms of anti-inflammatory and analgesic effects were also studied via assays of TNF-α, IL-1β, IL-6, and PGE2 in serum.Results: UPLC-Q-Exactive HRMS analysis showed that POEa and POEe mainly contained flavonoids including orientin, isoorientin, vitexin, luteolin, and quercetin. Furthermore, anti-inflammatory effects of POEa and POEe were evident in xylene induced ear edema. The paw edema in Freund’s complete adjuvant and carrageenan were significantly (P < 0.05, 0.01) inhibited by POEa (5, 7.5 g/kg). POEe (7.5 g/kg) was significantly (P < 0.05, 0.01) inhibited Freunds’ complete adjuvant induced paw edema and cotton pellet induced granuloma formation. Similarly, POEe significantly (P < 0.05, 0.01) inhibited the pain sensation in acetic acid induced writhing test. POEa (5, 7.5 g/kg) significantly (P < 0.05, 0.01) inhibited formaldehyde induced pain in both phases. POEa (7.5 g/kg) markedly (P < 0.05) prolonged the latency period of hot plate test after 30 and 60 min. The concentrations of TNF-α, IL-1β, IL-6, and PGE2 were significantly (P < 0.01) decreased by POEa (3.75, 5 g/kg).Conclusion: POEa and POEe have anti-inflammatory and analgesic effects, which was mainly relevant to the presence of flavonoids, including orientin, isoorientin, vitexin, luteolin, and quercetin. The mechanism of anti-inflammatory and analgesic effects of POEa may be to decrease the concentrations of TNF-α, IL-1β, IL-6, and PGE2 in serum.

show abstract

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory and Analgesic Effects of Polygonum orientale L. Extracts

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Animals in 13 groups, each consisting of 5 animals, were used. Intraperitoneal administration of 0.6% acetic acid induced abdominal writhings that were characterized by arching of back, extension of hind limbs and contraction of abdominal musculature 36 . For checking the involvement of cyclooxygenase and lipooxygenase pathway in the mode of action of the compound, Substance P was used whereas L-arginine and L-NAME were used to investigate the involvement of nitric acid pathway.…”

Section: Methodsmentioning

confidence: 99%

Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor

Singh

Kaur

et al. 2018

Sci Rep

View full text Add to dashboard Cite

The physiological consequences of COX-2 overexpression in the development of cancer, diabetes and neurodegenerative diseases have made this enzyme a promising therapeutic target. Herein, COX-2 active site was analyzed and new molecules were designed. We identified a highly potent molecule (S)-3a with IC50 value and the selectivity for COX-2 0.6 nM and 1666, respectively. The MTD of (S)-3a was 2000 mg kg−1 and its pharmacokinetic studies in rat showed t1/2 7.5 h. This compound reversed acetic acid induced analgesia and carragennan induced inflammation by 50% and 25% in rat when used at a dose 10 mg kg−1. Mechanistically, it was found that compound (S)-3a inhibits COX-2. Overall, the combination of physico-chemical and biological experiments facilitated the development of a new lead molecule to anti-inflammatory drug.

show abstract

“…Sobral (Myrtaceae) (Azevedo et al. 2016 ), Stachytarpheta cayennensis (Rich) Vahl. (Verbenaceae) (Penido, Costa, Futuro, et al.…”

Section: Medicinal Plants Having Anti-inflammatory With Incomplete Elunclassified

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

Ribeiro

Arruda

El-Salam

et al. 2018

Pharmaceutical Biology

100

View full text Add to dashboard Cite

Context: Inflammatory disorders are common in modern life, and medicinal plants provide an interesting source for new compounds bearing anti-inflammatory properties. In this regard, Brazilian medicinal plants are considered to be a promising supply of such compounds due to their great biodiversity.Objectives: To undertake a review on Brazilian medicinal plants with corroborated anti-inflammatory activities by selecting data from the literature reporting the efficacy of plants used in folk medicine as anti-inflammatory, including the mechanisms of action of their extracts and isolated compounds.Methods: A search in the literature was undertaken by using the following Web tools: Web of Science, SciFinder, Pub-Med and Science Direct. The terms ‘anti-inflammatory’ and ‘Brazilian medicinal plants’ were used as keywords in search engine. Tropicos and Reflora websites were used to verify the origin of the plants, and only the native plants of Brazil were included in this review. The publications reporting the use of well-accepted scientific protocols to corroborate the anti-inflammatory activities of Brazilian medicinal plants with anti-inflammatory potential were considered.Results: We selected 70 Brazilian medicinal plants with anti-inflammatory activity. The plants were grouped according to their anti-inflammatory mechanisms of action. The main mechanisms involved inflammatory mediators, such as interleukins (ILs), nuclear factor kappa B (NF-κB), prostaglandin E2 (PGE2), cyclooxygenase (COX) and reactive oxygen species (ROS).Conclusions: The collected data on Brazilian medicinal plants, in the form of crude extract and/or isolated compounds, showed significant anti-inflammatory activities involving different mechanisms of action, indicating Brazilian plants as an important source of anti-inflammatory compounds.

show abstract

Evidence of anti-inflammatory and antinociceptive activities of Plinia edulis leaf infusion

Cited by 25 publications

References 41 publications

Anti-inflammatory and Analgesic Effects of Polygonum orientale L. Extracts

Anti-inflammatory and Analgesic Effects of Polygonum orientale L. Extracts

Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor

Brazilian medicinal plants with corroborated anti-inflammatory activities: a review

Contact Info

Product

Resources

About