Abstract:Abstract:The potential of hexachlorobenzene (HCB) to promote the development of glutathione S-transferase placental form (GST-P) positive foci in the male F344/DuCrj (F344) rat liver was evaluated with 11 different dietary doses, ranging from 0.002 to 75 ppm, using a medium-term liver bioassay system. No mortalities caused by HCB treatment were encountered, and no clinical changes were apparent. The numbers and areas of GST-P positive foci in the 0.002 ppm to 40 ppm groups were comparable with the control valu… Show more
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