Evidence of a Role for Growth Hormone, but Not for Insulin-Like Growth Factors-l or -II in the Growth of the Neonatal Rat

Robinson, Geoffrey; Spencer, G. S. G.; Berry, Carole; Dobbie, P. M.; Hodgkinson, S. C.; Bass, J. J.

doi:10.1159/000243986

Cited by 14 publications

(7 citation statements)

References 15 publications

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“…The in vivo immunoneutralizing ability of the antiserum has been demonstrated in other studies [17],…”

Section: Preparation O F Antiseramentioning

confidence: 55%

“…It was specific for SRIF and was capable of binding 1.3 ng SRIF/ml as used in the experiments. The antiserum has been dem onstrated to have potent immunoneutralizing capacity in many trials in a number of species [14][15][16][17],…”

Section: Preparation O F Antiseramentioning

confidence: 99%

“…Blood samples were collected from some pups sacri ficed at birth and from pups at weaning on day 21. Plasma GF] concentrations were measured using an NIAMDD radioimmunoassay and plasma insulin-like growth factor (IGF)-l was measured by radioimmu noassay following acid-ethanol cryoprecipitation as de scribed elsewhere [17],…”

Section: Animalsmentioning

confidence: 99%

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Alteration of Maternal Growth Hormone Levels during Pregnancy Influences both Fetal and Postnatal Growth in Rats

Spencer¹,

Robinson²,

Berry³

et al. 1994

Neonatology

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To study the effects of exogenous growth hormone (GH) administration to the mother on fetal growth, dwarf rats with an isolated GH deficiency were given daily s.c. injections of GH throughout pregnancy. Fetuses were heavier in GH-treated mothers (p < 0.001), and pups from GH-treated mothers continued to grow faster (p < 0.001) than pups from control mothers throughout the postnatal growth period through to weaning. In normal Wistar rats, administration of a potent antiserum to somatostatin to pregnant rats increased the mean birth weight of the offspring (p < 0.01). Administration of GH to the mothers also significantly increased birth weight (p < 0.05), but administration of antiserum to rat GH resulted in a significant retardation of both fetal and placental growth (p < 0.001). These data suggest that maternal GH status is significantly involved in the growth of the fetal rat.

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“…The in vivo immunoneutralizing ability of the antiserum has been demonstrated in other studies [17],…”

Section: Preparation O F Antiseramentioning

confidence: 55%

Section: Preparation O F Antiseramentioning

confidence: 99%

See 1 more Smart Citation

Alteration of Maternal Growth Hormone Levels during Pregnancy Influences both Fetal and Postnatal Growth in Rats

Spencer¹,

Robinson²,

Berry³

et al. 1994

Neonatology

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“…Some authors have hypothesized that the response of GH to SRIF, but not circulating GH levels in neonatal pigs during the last part of pregnancy, is responsible for GH levels after birth [5] and appears to be related to growth rate [31]. However, this observation strictly regards only the last part of pregnancy because an anti-SRIF treatment of neonatal rats does not significantly modify growth rate [26]. Another approach to investigate GH axis involves the determination of GH-dependent markers.…”

Section: Discussionmentioning

confidence: 99%

IGF-I, IGFBP-2 and -3 but not GH concentrations are different in normal and poor growing piglets

et al. 2001

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-In this study we investigated the somatotropic axis in piglets with evident growth delay. Female Suffolk crossbred piglets (30 days old; N = 12) were divided into normal weight (10 ± 0.9 kg) and poor growing subjects (7 ± 0.5 kg) and bled for growth hormone (GH), Insulin-like growth factor-I (IGF-I), Insulin-like growth factor binding protein 2 and 3 (IGFBP-2 and -3) determination. Basal and induced-GH levels were not different in the groups. Plasma IGF-I concentrations were significantly different (p < 0.001): 101.8 ± 9.8 ng . mL -1 (normal weight group) and 39.5 ± 4.0 ng . mL -1 (poor growing group). IGFBP-2 and -3 concentrations were significantly (p < 0.001) lower in poor growing than in normal piglets. Piglet weight was positively correlated (r = 0.98, p < 0.001) with IGF-I and IGFBP-2 or -3 concentrations. Our data indicate that growth rate was not correlated to basal or secretagogue-induced GH secretion. growth hormone / somatotropic axis / insulin-like growth factor I / insulin-like growth factor binding protein / pigletRésumé -Les concentrations de IGF-I, IGFBP-2 et -3 sont différentes chez les porcelets normaux et chez les porcelets qui présentent un retard de croissance ; cette différence n'existe pas pour la GH. L'objet de cette étude est l'axe somatotrope chez les porcelets présentant un retard de croissance manifeste. Douze porcelets femelles croisés Suffolk (âgés de 30 jours) ont été subdivisés en deux groupes : sujets de poids normal (10 ± 0,9 kg ; N = 6) et sujets avec retard de croissance (7 ± 0,5 kg ; N = 6) : des prélèvement sanguins ont été effectués pour la détermination de l'hormone de croissance (GH), de l'Insulin-like growth factor I (IGF-I), et des Insulin-like growth factor binding protein-2 et -3 (IGFBP-2 et -3). Aucune différence n'a été observée entre les concentrations basale et induite

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“…Reduced levels of GHRH within the hypothalamus or altered GHRH action at the pituitary level during a critical developmental window have a lifelong impact on body weight [40,41,42], and induce an inadequate clonal expansion of the somatotrope population. The requirement of GHRH for the normal development of the somatotrope lineage is evident from studies examining the etiology of growth retardation in the spontaneous mutant mouse lit/lit , [40] or in humans with mutations in the GHRH receptor [43].…”

Section: D2rs and Ghrh-gh Regulationmentioning

confidence: 99%

New Insights into the Endocrine and Metabolic Roles of Dopamine D2 Receptors Gained from the <i>Drd2</i><sup>–/–</sup> Mouse

García-Tornadú

Millán²,

Recouvreux³

et al. 2010

Neuroendocrinology

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Dopamine D2 receptor (D2R) participation in prolactin regulation is well documented, but the role of D2Rs in the control of other hormones involved in growth, food intake and glucose metabolism has not been extensively studied. The study of D2R knockout mice (Drd2^–/–) puts forward new insights into the role of the D2R in growth hormone (GH)-releasing hormone-GH regulation, peptides involved in food intake, glucose homeostasis, as well as in prolactinoma development. The expected phenotype of chronic hyperprolactinemia and prolactinoma development was found in the Drd2^–/– mouse, and this model constitutes a valuable tool in the study of dopamine-resistant prolactinomas. Unexpectedly, these mice were growth retarded, and the importance of functional hypothalamic D2Rs in the neonatal period was revealed. In the Drd2^–/– mouse there was a failure of high neonatal GH levels and therefore the expansion of pituitary somatotropes was permanently altered. These mice also had increased food intake, and a sexually dimorphic participation of the D2R in food intake regulation is suggested. The effect described is probably secondary to D2R regulation of prolactin secretion. Furthermore, the negative modulation of D2Rs on α-melanocyte-stimulating hormone release and positive action on the hypothalamic expression of orexins reveals the complex D2R regulation of food intake. Finally, pancreatic D2Rs inhibit glucose-stimulated insulin release. Lack of dopaminergic inhibition throughout development in the Drd2^–/– mouse may exert a gradual deteriorating effect on insulin homeostasis, so that eventually glucose intolerance develops. These results highlight the complex endocrine actions of the D2Rs at different levels, hypothalamus, pituitary or pancreas, which function to improve fitness, reproductive success and survival.

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Evidence of a Role for Growth Hormone, but Not for Insulin-Like Growth Factors-l or -II in the Growth of the Neonatal Rat

Cited by 14 publications

References 15 publications

Alteration of Maternal Growth Hormone Levels during Pregnancy Influences both Fetal and Postnatal Growth in Rats

Alteration of Maternal Growth Hormone Levels during Pregnancy Influences both Fetal and Postnatal Growth in Rats

IGF-I, IGFBP-2 and -3 but not GH concentrations are different in normal and poor growing piglets

New Insights into the Endocrine and Metabolic Roles of Dopamine D2 Receptors Gained from the <i>Drd2</i><sup>–/–</sup> Mouse

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