Evidence of a role for a guanine nucleotide binding protein during growth and morphogenesis in Candida albicans

Sex and Crime: Heterotrimeric G Proteins in Fungal Mating and Pathogenesis

“…cag1 heterozygous and homozygous null mutants had no discernible morphological phenotypes when incubated in human serum (Sadhu et al, 1992;Ward et al, 1997). Upon incubation in nutrient-rich medium, however, a major increase in the level of germ tube formation was observed in the mutant strains (Ward et al, 1997). This may indicate that, analogous to the situation in S. cerevisiae, the free ␤␥ dimer might constitutively transmit a morphogenetic signal which is normally induced by human serum (Ward et al, 1997).…”

“…Therefore it has been inferred that C. albicans may have an analogous mating-type controlling system, although haploid cells of C. albicans have so far remained undetected (Sadhu et al, 1992). cag1 heterozygous and homozygous null mutants had no discernible morphological phenotypes when incubated in human serum (Sadhu et al, 1992;Ward et al, 1997). Upon incubation in nutrient-rich medium, however, a major increase in the level of germ tube formation was observed in the mutant strains (Ward et al, 1997).…”