Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree

Suggestive linkage of schizophrenia to 5p13 in Costa Rica

“…It is of interest to note that three studies have suggested linkage between markers on chromosome 5p and schizophrenia. [18][19][20] While one study suggests linkage to the same marker, D5S426, 19 the other studies suggest linkage to flanking regions, 2 Mb upstream and 27 Mb downstream of D5S426. 18,20 Materials and methods…”

“…Based on the chromosome 5 results, a haplotype was established by parsimony which includes markers D5S426-D5S2076 ( 20 By investigating the effects of the assumptions made in the analysis parameters, Silverman et al 20 were able to demonstrate that, with increasing penetrance values, evidence of linkage increases (maximum multipoint lod score of 4.37, assuming a penetrance of 90%). A linkage study of schizophrenia, schizoaffective disorder-depressed and cluster 'A' personality disorder in 30 pedigrees (77% African American, 23% Caucasian) found evidence of linkage to the same region, with a maximum nonparametric lod score of 2.55 at marker D5S426.…”

Identification of a novel polymorphism of the human dopamine transporter (DAT1) gene and the significant association with alcoholism

“…1,2 Family, twin, and adoption studies have indicated substantial heritability in the etiology of alcoholism 3 and schizophrenia, 1,[4][5][6] but the molecular mechanisms of pathogenesis are still poorly understood. Dopaminergic brain systems play important roles in drug reward and reinforcement, therefore attention is focused on genes expressed in these circuits as candidates contributing to alcoholism.…”

Localization of genes modulating the predisposition to schizophrenia: a revision

“…That is, these authors discovered a locus (5q11-13) occupied by alleles (i.e., modulations of a gene determining opposing traits) which in some families interferred with susceptibility to schizophrenia. These findings, however, along with those of Bassett et al (1988), were not confirmed by other workers (e.g., Hallmayer et al, 1992;Macciardi et al, 1992;Gurling, 1994), with new evidence suggesting a "schizophrenia locus" (D5S111, 5p14.1-13.1) on the short arm of chromosome 5 (Silverman et al, 1996).…”

“…Short arm of chromosome 6 at 6p24-22, Wang et al (1995Wang et al ( , 1996; Pujana et al (1997) loci D6S296, D6S274, D6S285, D6S260 Riley et al (1997) Chromosome 9 at 9q34.3 Moises et al (1995b) Proposed additional new regions on chromosomes 9 and 20 Kendler et al (1996) Locus of vulnerability on chromosome 8p Pulver et al (1995) Chromosomes 3 and 8 (3p and 8p) as "potential loci" Mulcrone et al (1995) Long arm of chromosome 11, the gene for the D 2 dopamine receptor Williams et al (1996) Proposed an association between schizophrenia and T102C polymorphism in the gene for the type 2a serotonin receptor on the long arm of chromosome13 Lin et al (1997) Chromosome 13 at 13q14.1-q32 Gelernter et al (1995) Proposed linkage studies with the SLC6A4 locus of the gene for serotonin transporter protein on chromosome 17 at 17q12, and the D17S73 and D17S58 markers Schwab et al (1998) Chromosome 18 at 18p Crocq et al (1992); Mant et al (1994); Griffon et al (1996) Chromosome 3 at q13.3, the gene for human D 3 dopamine receptor Silverman et al (1996) Short arm of chromosome 5 at 5p14.1-13.1, locus D5S111 Shaw et al (1998) Chromosomes 1, 2, 4, 11, 13 Wright et al (1996Wright et al ( , 1998 HLA DRB1 gene locus on chromosome 6 at 6p21.3 no evidence in favor of a link between a locus predisposing to schizophrenia and the pseudoautosomal region. Even so, DeLisi et al (l994b) included in their revision two group studies on samples of Swedish and American families reporting data suggesting that the frequency of XXX and XXY aneuploid sex-chromosomes was higher in populations of patients with schizophrenia, claiming that too few had survived to determine if an association also existed in respect to XYY chromosomes.…”