Evidence, knowledge, implementation: glossary of terminology

Medicine-based evidence: the case of antidepressants in patients with coronary artery disease

“…Although randomised controlled trials (RCTs), and systematic reviews of data extracted from RCTs, are at the pinnacle of the evidence-based hierarchy, aiming to assist health care professionals in making decisions, in clinical practice making decisions in the absence of evidence, or in the presence of incomplete evidence, is a common problem (Barbui, 2017). In such situations of clinical uncertainty, health care professionals have increased responsibility, as the provision of care would need to be as much in line as possible with the limited evidence available and would also require strict monitoring (Barbui et al ., 2002).…”