Evidence grade associating periodontitis to preterm birth and/or low birth weight: I. A systematic review of prospective cohort studies

Guglielmetti, Mariana Rocha; Pannuti, Cláudio Mendes; Chambrone, Luiz Armando

doi:10.1111/j.1600-051x.2011.01755.x

Cited by 131 publications

(138 citation statements)

References 52 publications

(149 reference statements)

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“…Poor dental health can adversely affect a number of systemic conditions and diseases, such as cardiovascular diseases (4), diabetes (5), respiratory diseases (6), and inflammatory bowel diseases (7), and can even lead to preterm delivery (8,9) and systemic disease (10)(11)(12). However, the associations between periodontal disease and sperm abnormalities have not been adequately investigated.…”

Section: Introductionmentioning

confidence: 99%

Association between periodontal status and idiopathic male infertility

et al. 2016

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About 30% of male infertility cases are idiopathic. Previous studies reported a positive correlation between deep periodontal pockets and sperm sub-motility, which suggests that periodontitis might have a role in idiopathic semen abnormality pathospermia. We evaluated correlations between periodontal infection parameters and the results of sperm analysis of men with idiopathic infertility. In this observational study, semen quality and periodontal status were analyzed for 95 otherwise healthy men attending an andrology unit for sperm analysis. Half the men in the sperm pathology and normozoospermia groups (50.8% and 50%, respectively) had poor periodontal status. Among the 95 participants, 38% had oligozoospermia, 28% had asthenozoospermia, 16% had cryptozoospermia, and 15% were classified as normozoospermic. Sperm pathology category was not associated with frequency of deep periodontal pockets or calculus. Bleeding on probing was significantly lower among men with asthenozoospermia than among those with normozoospermia. Poor periodontal status was not associated with any sperm pathology category or parameter. In contrast with previous findings, the present results indicate that pathospermia and poor semen quality are not associated with periodontal infection in men with idiopathic infertility. (J Oral Sci 58, 247-253, 2016)

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Section: Introductionmentioning

confidence: 99%

Association between periodontal status and idiopathic male infertility

et al. 2016

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“…Prospective cohort studies, which show that periodontal disease is associated with an increased risk of premature death from any cause, suggest the hypothesis that periodontitis may be a risk factor for other diseases (DeStefano et al 1993, Linden et al 2012. A large body of research work has investigated periodontitis as an independent risk factor for atherosclerosis including stroke (Wu et al 2000) and coronary heart disease (Bahekar et al 2007, Humphrey et al 2008, Friedewald et al 2009, Kebschull et al 2010, Buhlin et al 2011; adverse pregnancy outcomes (Chambrone et al 2011a,b, Matevosyan 2011; and diabetes (Demmer et al 2008, Allen et al 2011, Ide et al 2011, Preshaw et al 2012.…”

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confidence: 99%

Periodontal systemic associations: review of the evidence

Linden

Lyons

Scannapieco

2013

Journal of Periodontology

286

147

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Linden GJ, Lyons A, Scannapieco FA. Periodontal systemic associations: review of the evidence. AbstractAim: To critically appraise recent research into associations between periodontal disease and systemic diseases and conditions specifically respiratory disease, chronic kidney disease, rheumatoid arthritis, cognitive impairment, obesity, metabolic syndrome and cancer. Methods: A MEDLINE literature search of papers published between 2002 and April 2012 was conducted. Studies that included periodontitis as an exposure were identified. Cross-sectional epidemiological investigations on large samples, prospective studies and systematic reviews formed the basis of the narrative review. A threshold set for the identification of periodontitis was used to identify those studies that contributed to the conclusions of the review. Results: Many of the investigations were cross-sectional secondary analyses of existing data sets in particular the NHANES studies. There were a small number of systematic reviews and prospective studies. There was substantial variability in the definitions of exposure to periodontitis. A small number of studies met the threshold set for periodontitis and supported associations; however, in some of the chronic diseases there were no such studies. There was strong evidence from randomized controlled trials that interventions, which improve oral hygiene have positive effects on the prevention of nosocomial pneumonias. Conclusions: There was substantial heterogeneity in the definitions used to identify periodontitis and very few studies met a stringent threshold for periodontitis. Published evidence supports modest associations between periodontitis and some, although not all, of the diseases and conditions reviewed. There is a need to reach a consensus on what constitutes periodontitis for future studies of putative associations with systemic diseases.

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“…23 Although it has been asserted that periodontopathogens from oral infection can disseminate to distant body sites and thus result in the delivery of PLBW infants, results have been inconclusive. 24,25,26,27 Some studies have demonstrated positive correlations, while others have not. 28,29,30,31,32,33,34,35 Although these results seem contradictory, factors such as race, geographical location, and socioeconomic standards have not been adequately adjusted for.…”

Section: Discussionmentioning

confidence: 99%

Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

Gamal

Agoor

Shaker

et al. 2017

Perio J

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Background: The present study was conducted to evaluate the levels of interleukin (IL) -17 in gingival crevicular fluid (GCF) and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Methods: This case-control study included a random sample of 40 female patients, aged 18 to 35 years, who were assigned to one of the following four groups (10 subjects each): group 1 included patients who underwent spontaneous preterm birth (PB) and were diagnosed with chronic periodontitis upon clinical examination (preterm/periodontitis); group 2 included patients who underwent spontaneous PB and who had a healthy periodontium upon clinical examination (preterm/healthy periodontium); group 3 included patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination (term/periodontitis); and group 4 included patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (term/healthy periodontium). GCF and placental tissue samples were obtained from each patient and IL-17 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: GCF levels of IL-17 were significantly higher (P=0.010) in patients with chronic periodontitis compared to those with a healthy periodontium. No significant differences were observed in IL-17 levels in placental tissue samples of all study groups. Conclusion: An association between chronic periodontitis and preterm labor could not be established based on IL-17 levels measured in the present study.

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Evidence grade associating periodontitis to preterm birth and/or low birth weight: I. A systematic review of prospective cohort studies

Abstract: Although this SR found a consistent association between periodontitis and PB and/or LBW, this finding should be treated with great caution until the sources of heterogeneity can be explained.

Cited by 131 publications

References 52 publications

Association between periodontal status and idiopathic male infertility

Association between periodontal status and idiopathic male infertility

Periodontal systemic associations: review of the evidence

Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

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