2021
DOI: 10.1111/bjd.20084
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Evidence from a humanized mouse model of androgenetic alopecia that platelet‐rich plasma stimulates hair regrowth, hair shaft diameter and vellus‐to‐terminal hair reconversion in vivo

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Cited by 5 publications
(6 citation statements)
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References 8 publications
(13 reference statements)
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“…Using this more accurate methodology, we asked in the current pilot studywhether a former T HF, which has been transformed into a V HF under androgen-stimulation, can be reconverted to a T HF under standard AGA therapy in a well-defined area of mpAGA scalp skin in vivo . To address this question, we have re-analysed human scalp skin samples derived from our novel humanized mpAGA mouse model, in which human mpAGA scalp xenotransplants had been treated long-term with MXL or platelet-rich plasma (PRP) in vivo ( 10 , 11 ), applying the objective histomorphometry criteria listed in Fig. 1A .…”
Section: Methodsmentioning
confidence: 99%
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“…Using this more accurate methodology, we asked in the current pilot studywhether a former T HF, which has been transformed into a V HF under androgen-stimulation, can be reconverted to a T HF under standard AGA therapy in a well-defined area of mpAGA scalp skin in vivo . To address this question, we have re-analysed human scalp skin samples derived from our novel humanized mpAGA mouse model, in which human mpAGA scalp xenotransplants had been treated long-term with MXL or platelet-rich plasma (PRP) in vivo ( 10 , 11 ), applying the objective histomorphometry criteria listed in Fig. 1A .…”
Section: Methodsmentioning
confidence: 99%
“…(A) Overview of the experimental design. Biopsies were obtained from 10 patients with androgenetic alopecia (AGA) and transplanted onto 19 severe combined immunodeficiency (SCID)/beige mice, which were treated with either MXL or PRP ( 10 , 11 ). The paraffin-embedded sections were cut and stained with haematoxylin and eosin (H&E) to define the hair follicles (HFs) according to their hair shaft diameter ( 3 ) and with Mason’s trichrome to distinguish the red-staining arrector pili muscle (APM) ( 7 ).…”
Section: Methodsmentioning
confidence: 99%
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