Evidence for zoonotic origins of Middle East respiratory syndrome coronavirus

Han, Hui; Yu, Hao; Yu, Xue Jie

doi:10.1099/jgv.0.000342

Cited by 42 publications

(37 citation statements)

References 63 publications

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“…While SARS fatality rate was 8%, MERS fatality rate was 36% (by 9th of November 2016, the number of laboratory confirmed infections was 1813 and the number of reported deaths was 645) . Six coronavirus strains were reported to be zoonotic (ie, transmission of infections from animals to humans is possible) . These human coronaviruses were 229E and NL63 (belonging to Alphacoronavirus ) and OC43, HKU1, SARS, and MERS (belonging to Betacoronavirus ) .…”

Section: Introductionmentioning

confidence: 99%

Quantitative structure‐activity relationship and molecular docking revealed a potency of anti‐hepatitis C virus drugs against human corona viruses

Elfiky

Mahdy

Elshemey

2017

Journal of Medical Virology

117

108

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A number of human coronaviruses (HCoVs) were reported in the last and present centuries. Some outbreaks of which (eg, SARS and MERS CoVs) caused the mortality of hundreds of people worldwide. The problem of finding a potent drug against HCoV strains lies in the inability of finding a drug that stops the viral replication through inhibiting its important proteins. In spite of its limited efficacy and potential side effects, Ribavirin is extensively used as a first choice against HCoVs. Therefore, scientists reverted towards the investigation of different drugs that can more specifically target proteins. In this study, four anti-HCV drugs (one approved by FDA and others under clinical trials) are tested against HCoV polymerases. Quantitative Structure-Activity Relationship (QSAR) and molecular docking are both used to compare the performance of the selected nucleotide inhibitors to their parent nucleotides and Ribavirin. Both QSAR and molecular docking showed that IDX-184 is superior compared to Ribavirin against MERS CoV, a result that was also reported for HCV. MK-0608 showed a performance that is comparable to Ribavirin. We strongly suggest an in vitro study on the potency of these two drugs against MERS CoV.

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Section: Introductionmentioning

confidence: 99%

Quantitative structure‐activity relationship and molecular docking revealed a potency of anti‐hepatitis C virus drugs against human corona viruses

Elfiky

Mahdy

Elshemey

2017

Journal of Medical Virology

117

108

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“…(4-7) MERS-CoV is transmissible from animals to humans. (8) According to the analysis of viral genomes in animals, it was found that the evolution of MERS-CoV is related to bats and camels. (9) Signs and symptoms of MERS-CoV vary.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

Middle East Respiratory Syndrome Coronavirus: Are Makkah Medical Students Sufficiently Aware of It?

Khairoalsindi¹,

Tayeb²,

Mandora³

et al. 2017

IJAR

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“…MERS-CoV is a known zoonosis with evidence supporting the role of bats and camels as reservoir of infection [2]. Previous studies suggest that MERS-CoV has been circulating for decades as an endemic disease in dromedary camels without large scale…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and predictors of survival of MERS-CoV infections in Riyadh region, 2014–2015

Al-Jasser

Nouh

Youssef³

2019

Journal of Infection and Public Health

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a b s t r a c tBackground: MERS-CoV emerged as a zoonotic disease in Saudi Arabia with 1437 cases as of July 2016. This study aimed at describing the epidemiology of MERS-CoV infection, clinical aspects of the disease and the determinants of survival. Methods: The medical records of Prince Mohamed Bin Abdulaziz Hospital were reviewed between April 2014 and December 2015 to identify admission and discharge with MERS-CoV. Patient's characteristics, epidemiologic and clinical data and laboratory results were extracted and described. Logistic regression analyses were used to model the determinants of the survival of these patients. Significance of the results were judged at the 5% level. Results: 249 confirmed cases were admitted mostly in August (20.48%) and September (14.86%) of the year 2015. A third (39.36%) reported contact with an index case, developed the disease after 6.2 days and continued to shed the virus for 13.17 days on average. The case fatality rate was 20.08%. Independent predictors of being discharged alive among confirmed cases were younger age (OR A = 0.953), breathing ambient air (OR A = 8.981), not being transferred to the ICU (OR A = 24.240) and not receiving renal replacement therapy (OR A = 8.342). These variables explain 63.9% of the variability of patients' status at discharge. Conclusion: MERS-CoV spread from human-to-human as community acquired and nosocomial infection. The study identified high risk patients in need for special medical attention in order to improve patients' outcome.

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Evidence for zoonotic origins of Middle East respiratory syndrome coronavirus

Cited by 42 publications

References 63 publications

Quantitative structure‐activity relationship and molecular docking revealed a potency of anti‐hepatitis C virus drugs against human corona viruses

Quantitative structure‐activity relationship and molecular docking revealed a potency of anti‐hepatitis C virus drugs against human corona viruses

Middle East Respiratory Syndrome Coronavirus: Are Makkah Medical Students Sufficiently Aware of It?

Epidemiology and predictors of survival of MERS-CoV infections in Riyadh region, 2014–2015

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