We study the interplay of spin-orbit coupling (SOC) and strong p-wave interaction to the scattering property of spin-1/2 ultracold Fermi gases. Based on a two-channel square-well potential generating p-wave resonance, we show that the presence of an isotropic SOC, even for its length much longer than the potential range, can greatly modify the p-wave short-range boundary condition(BC). As a result, the conventional p-wave BC cannot predict the induced molecules near p-wave resonance, which can be fully destroyed to vanish due to strong interference between s-and p-wave channels. By analyzing the intrinsic reasons for the breakdown of conventional BC, we propose a new p-wave BC that can excellently reproduce the exact molecule solutions and also equally apply for a wide class of single-particle potentials besides SOC. This work reveals the significant effect of SOC to both the short-and long-range properties of fermions near p-wave resonance, paving the way for future exploring interesting few-and many-body physics in such system.The interplay of spin-orbit coupling (SOC) and interaction has generated tremendous research interests in condensed matter physics [1,2], while ultracold atomic gases offer an ideal platform for its study giving successful realizations of synthetic SOC using Raman lasers [3][4][5][6][7] and highly tunable interactions via Feshbach resonances [8]. Nevertheless, before studying the complex many-body physics the very first question to address is how to model the fundamental two-body interactions. A crucial factor here is the asymptotic behavior of two-body wave function in the short-range limit, called the shortrange boundary condition(BC), which is the basis for constructing the Huang-Yang pseudo-potentials [9,10] and also equivalent to the use of renormalized contact models [11,12]. In the presence of SOC, studies have shown that the usual s-wave short-range BC, giving the conventional s-wave models, is hardly modified near swave resonances given the typical length of realistic SOC much longer than the potential range [13][14][15]. Despite the negligible short-range consequence, SOC can greatly change the long-range (low-energy) scattering properties from near the threshold [13,14,16] to intermediate energy regime [16][17][18]. Moreover, with conventional s-wave models it has been found that SOC can induce shallow molecules [19] and universal trimers [20,21] more easily, and lead to various fascinating many-body phenomena in both bosons and fermions atomic systems [22][23][24][25][26].Besides s-wave, the p-wave interacting atomic gases have also attracted great attention in recent years [8,27], in particular, in view of the very recent explorations of universal properties near p-wave resonance [28][29][30][31]. In this work, we study the interplay of SOC and strong pwave interaction to the short-range and long-range twobody physics. Specifically, we ask the question how would SOC affect the p-wave short-range BC and induce shallow molecules? There have been a few related discussions in li...