Evidence for U.S. Preventive Services Task Force (USPSTF) Recommendations Against Routine Mammography for Females between 40-49 Years of Age

Karimi, Parviz; Shahrokni, Armin; Moradi, Sedighe

doi:10.7314/apjcp.2013.14.3.2137

Cited by 9 publications

(4 citation statements)

References 25 publications

(27 reference statements)

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“…Breast cancer accounts for 22.9% of all cancers in women [ 1 ]. It is a hormone-dependent disease, with estrogens playing a dominant role in both cancer initiation and progression.…”

Section: Introductionmentioning

confidence: 99%

Chaperone gp96 mediates ER-α36 cell membrane expression

Deng

Liu

et al. 2015

Oncotarget

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ER (estrogen receptor)-α36, a variant of human ERα, activates non-genomic cell signaling pathways. ER-α36 on the cell membrane plays a role in breast cancer growth and development, and contributes to tamoxifen resistance. However, it is not understood how cell membrane expression of ER-α36 is regulated. In this study, we investigated the role of cell membrane glycoprotein 96 (mgp96) in the regulation of ER-α36 expression and signaling. We found that the C-terminal domain of mgp96 directly interacts with ER-α36 on the cell membrane of breast tumor cells. This interaction stabilizes the ER-α36 protein, thereby increasing its signaling, which, in turn, increases tumor cell growth and invasion. Moreover, targeting mgp96 with siRNA or monoclonal antibody (mAb) blocks the mgp96-ER-α36 interaction and inhibits breast cancer growth and invasion both in vitro and in vivo. These results provide insights into the modulation of cell membrane ER-α36 expression and suggest that mgp96 could be a potential therapeutic target for ER-α36-overexpressing breast cancer.

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“…Breast cancer accounts for 22.9% of all cancers in women [ 1 ]. It is a hormone-dependent disease, with estrogens playing a dominant role in both cancer initiation and progression.…”

Section: Introductionmentioning

confidence: 99%

Chaperone gp96 mediates ER-α36 cell membrane expression

Deng

Liu

et al. 2015

Oncotarget

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“…However, women usually do not attend screening programs because of a lack of education and information. We also noted inadequate mammography screening in our analysis [12–14]. …”

Section: Discussionmentioning

confidence: 94%

Assessment of general characteristics of patients with primary metastatic breast carcinoma: single center experience

Üyetürk¹,

Budakoğlu²,

Türker³

et al. 2013

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IntroductionBreast cancer (BC) is a heterogeneous disease. Several subgroups have been identified, according to the clinical presentation and radiographic, pathological, biological, and molecular characteristics of the tumor. Intrinsic genetic heterogeneity may be responsible for these differences. To date, little is known about the clinical features and outcome of patients with primary metastatic BC (PMBC) defined as those presenting with stage IV disease.Material and methodsBetween September 2007 and May 2011, BC patients who were admitted to a clinic were assessed. Patients with PMBC were included in this retrospective analysis. The patients’ demographic characteristics, treatment schedules, and survival data were recorded.ResultsOf 2478 BC patients, 102 (4.1%) with PMBC were included in the analysis. The median age of the patients was 50 (26–90) years. Only four patients (3.9%) had previously undergone mammography. The median progression-free survival (PFS) and overall survival (OS) were 30 and 66 months, respectively. The PFS and OS were unaffected by age, menopausal status, ECOG, histology, or tumor grade. Both PFS and OS were affected by HR status (log rank p = 0.006, log rank p = 0.04), HER2 status (p = 0.001, p = 0.005), site of metastasis (p = 0.01, p = 0.04), radiotherapy (p = 0.04, OS p = 0.03), and bisphosphonate treatment (p = 0.02, p = 0.006). PFS was greater in the hormone therapy group (43 months, p = 0.03) while OS was greater in the patients that received chemotherapy (76 months, p = 0.01).ConclusionsMammography should be given greater emphasis, considering its importance in the prevention of PMBC. As a treatment option for bone and soft tissue metastatic PMBC patients, hormone therapy should be effective as a first-line treatment.

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“…The inadequacy of mammography screening programs has led to the diagnosis of women with breast cancer in the late stages, and it has been found that the five-year survival rate falls to the range of 10-40% (15,16). In 2014, the World Health Organization prepared guidelines for breast cancer, 40-49 age group, 50-69 age group, and 70-74 age group (3).…”

Section: Discussionmentioning

confidence: 99%

The Collection of Epidemiological Data of the Women Undergoing Mammography in Suburban Area of Mersin

Dogen¹

2019

Ulutas Med J

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Breast cancer constitutes 25% of cancers in women, and one out of nine women is confronted with breast cancer in one part of their lives (1). The distribution of these women, according to the age group, shows that 85% are over 40 years of age (2). The World Health Organization (WHO) recommends screening mammography for women over 40 years of age, and screening programs vary from country to country (3). In the United Kingdom (4) the National Health Service Breast Screening Program, (5) the United States Preventive Services Task Force in the United States, Breast Cancer Service in Sweden (6), the country-wide mammography screening breast cancer. These programs demonstrate the usefulness of mammography (4-6). Public Health Agency by

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Evidence for U.S. Preventive Services Task Force (USPSTF) Recommendations Against Routine Mammography for Females between 40-49 Years of Age

Cited by 9 publications

References 25 publications

Chaperone gp96 mediates ER-α36 cell membrane expression

Chaperone gp96 mediates ER-α36 cell membrane expression

Assessment of general characteristics of patients with primary metastatic breast carcinoma: single center experience

The Collection of Epidemiological Data of the Women Undergoing Mammography in Suburban Area of Mersin

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