Evidence for two distinct domains of negative symptoms: Confirming the factorial structure of the CAINS

Richter, Janina; Hesse, Klaus; Schreiber, Lisa; Burmeister, Carolin P.; Eberle, Mark-Christian; Eckstein, Kathrin N.; Zimmermann, Lina; Wildgruber, Dirk; Klingberg, Stefan

doi:10.1016/j.psychres.2018.12.043

Cited by 17 publications

(9 citation statements)

References 59 publications

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“…For example, the National Institute of Mental Health Consensus Development Conference identified five domains of negative symptoms, including blunted affect, alogia, anhedonia, avolition, and asociality (Kirkpatrick et al, 2006), and other work has verified this factor structure (G. P. Strauss et al, 2018). At the same time, studies examining the explanatory power of these constructs suggest that blunted affect and alogia might be both explained by a broader "inexpressivity factor" and anhedonia, avolition, and asociality may be similarly related to each other under the umbrella of "avolition" (Kotov et al, 2016;Marder & Galderisi, 2017;Richter et al, 2019;G. P. Strauss et al, 2013).…”

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confidence: 84%

Development of the Thought Disorder Measure for the Hierarchical Taxonomy of Psychopathology

et al. 2021

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The Hierarchical Taxonomy of Psychopathology consortium aims to develop a comprehensive self-report measure to assess psychopathology dimensionally. The current research describes the initial conceptualization, development, and item selection for the thought disorder spectrum and related constructs from other spectra. The thought disorder spectrum is defined primarily by the positive and disorganized traits and symptoms of schizophrenia-spectrum disorders. The Thought Disorder Sub-Workgroup identified and defined 16 relevant constructs and wrote 10 to 15 items per each construct. These items were administered, along with detachment and mania items, to undergraduates and people with serious mental illness. Three hundred and sixty-five items across 25 scales were administered. An exploratory factor analysis of the scale scores suggested a two-factor structure corresponding to positive and negative symptoms for two samples. The mania scales loaded with the positive factor, while the detachment scales loaded with the negative factor. Item-level analyses resulted in 19 preliminary scales, including 215 items that cover the range of thought disorder pathology, and will be carried forward for the next phase of data collection/analysis.

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confidence: 84%

Development of the Thought Disorder Measure for the Hierarchical Taxonomy of Psychopathology

et al. 2021

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“…However, the term negative symptoms encompasses a diverse group of symptoms that potentially reflect different mechanistic processes. Negative symptoms have been separated by factor analysis into two sub-domains of avolition-apathy, which has positive loadings on avolition, asociality and anhedonia, and diminished expression, which has positive loadings on blunted affect and alogia (Liemburg et al, 2013, Messinger et al, 2011, Richter et al, 2019. Some evidence suggests these domains may respond differently to adjunctive treatment given with antipsychotic medication; for example Zoccalli et al (2004) found that avolitionapathy and anhedonia-asociality, were statistically significantly improved in patients receiving a mirtazapine augmentation of clozapine, while there was no significant difference between the groups for alogia or affective flattening.…”

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confidence: 99%

Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment

Krynicki

Dazzan

Pariante

et al. 2021

Brain, Behavior, and Immunity

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“…Negative symptom assessment was hardly reliable in 7 studies, 56 , 57 , 59 , 61 , 67 , 70 , 73 reliable in 2 studies, 68 , 71 and highly reliable in 13 studies. 23 , 24 , 58 , 60 , 62–66 , 69 , 72 , 74 , 75 …”

Section: Resultsmentioning

confidence: 99%

“…Four models were based on the NSA, 56 , 57 , 63 , 66 7 on the BNSS, 23 , 24 , 62 , 64 , 73 and the others were equally divided between the SANS, 23 , 58 , 59 , 65 , 67 the PANSS, 60 , 61 , 68 , 70 , 71 and the CAINS. 23 , 69 , 72 , 74 , 75 …”

Section: Resultsmentioning

confidence: 99%

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What is the Best Latent Structure of Negative Symptoms in Schizophrenia? A Systematic Review

Haguiara

Koga

Diniz

et al. 2021

Schizophrenia Bulletin Open

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Background Determining the best latent structure of negative symptoms in schizophrenia could benefit assessment tools, neurobiological research, and targeted interventions. However, no review systematically evaluated studies that assessed and validated latent models of negative symptoms. Objective To identify and evaluate existing latent structure models in the literature of negative symptoms and to determine the best model. Method Systematic search of MEDLINE, EMBASE, and Scopus on July 19, 2020, for confirmatory factor analysis models of negative symptoms in patients with schizophrenia. The available evidence was assessed through 2 sets of criteria: (1) study design quality—based on negative symptoms assessment and modeling strategy and (2) psychometric quality and model fit—based on fit indices and factor definition quality. Results In total, 22 studies (n = 17 086) from 9 countries were included. Studies differed greatly regarding symptom scales, setting, and sample size (range = 86–6889). Dimensional models included 2–6 factors (median = 4). Twelve studies evaluated competing models and adopted appropriate instruments to assess the latent structure of negative symptoms. The 5-factor and hierarchical models outperformed unitary, 2-factor, and 3-factor models on all direct comparisons, and most of the analyses derived from the Brief Negative Symptom Scale. Considering the quality criteria proposed, 5-factor and hierarchical models achieved excellent fit in just one study. Conclusions Our review points out that the 5-factor and hierarchical models represent the best latent structure of negative symptoms, but the immaturity of the relevant current literature may affect the robustness of this conclusion. Future studies should address current limitations regarding psychometric properties and also address biological and clinical validity to refine available models.

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Evidence for two distinct domains of negative symptoms: Confirming the factorial structure of the CAINS

Cited by 17 publications

References 59 publications

Development of the Thought Disorder Measure for the Hierarchical Taxonomy of Psychopathology

Development of the Thought Disorder Measure for the Hierarchical Taxonomy of Psychopathology

Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment

What is the Best Latent Structure of Negative Symptoms in Schizophrenia? A Systematic Review

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