Evidence for TRP Channel Sensitization in IBS with Histamine 1 Receptor Antagonism as Effective Treatment

Balemans, Dafne; Aguilera‐Lizarraga, Javier; Florens, Morgane; Theofanous, Stavroula; Perna, Eluisa; Merwe, Schalk van der; Wouters, Mira M.; Boeckxstaens, Guy E.

doi:10.1016/s0016-5085(17)30683-2

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Diarrhea and Diarrhea-predominant Ibs (Ibs-d)1

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2017

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“…In IBS patients, there is sensitization of TRPV1 channels, which is mediated by histamine and/or its metabolite imidazole acetaldehyde, in the rectal submucosal plexus. [35,36] In a 12-week, double-blind, placebo-controlled study, the HRH1 receptor antagonist ebastine (20mg once daily) reduced visceral hypersensitivity, and improved symptoms, including abdominal pain, versus placebo. [35] (Table 1).…”

Section: Diarrhea and Diarrhea-predominant Ibs (Ibs-d)mentioning

confidence: 99%

Existing and emerging therapies for managing constipation and diarrhea

Bharucha

Wouters

Tack

2017

Current Opinion in Pharmacology

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Functional bowel disorders (i.e., constipation and diarrhea) are characterized by abdominal pain, bloating, distention, and/or bowel habit abnormalities in the absence of obvious anatomic or physiologic abnormalities on routine diagnostic tests. These symptoms are attributable to gastrointestinal sensorimotor dysfunctions resulting from peripheral and/or central mechanisms. Available drugs target the underlying bowel disturbance (ie, constipation, diarrhea, or both), supplemented when necessary by management of pain. Osmotic and stimulant laxatives, secretagogues, and serotonin 5-HT4 receptor agonists are approved for treating constipation. Loperamide, anticholinergic agents, rifaximin, bile-acid binding agents, eluxadoline, and clonidine are used to treat diarrhea. Several exciting new compounds, some of which have been evaluated in humans, are currently under development.

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Section: Diarrhea and Diarrhea-predominant Ibs (Ibs-d)mentioning

confidence: 99%