Evidence for the vitamin D hypothesis: The NHANES III extended mortality follow-up

Daraghmeh, Ahmad; Bertoia, Monica L.; Al-Qadi, Mazen O.; Abdulbaki, Abdulrahman; Roberts, Mary B.; Eaton, Charles B.

doi:10.1016/j.atherosclerosis.2016.04.007

Cited by 32 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data collected were used to study the prevalence of health behaviors and risk factors, including anthropometric parameters [27, 32–35]. Subjects were interviewed and examined during 1988–1994.…”

Section: Methodsmentioning

confidence: 99%

An Anthropometric Risk Index Based on Combining Height, Weight, Waist, and Hip Measurements

Krakauer

Krakauer²

2016

Journal of Obesity

117

View full text Add to dashboard Cite

Body mass index (BMI) can be considered an application of a power law model to express body weight independently of height. Based on the same power law principle, we previously introduced a body shape index (ABSI) to be independent of BMI and height. Here, we develop a new hip index (HI) whose normalized value is independent of height, BMI, and ABSI. Similar to BMI, HI demonstrates a U-shaped relationship to mortality in the Third National Health and Nutrition Examination Survey (NHANES III) population. We further develop a new anthropometric risk index (ARI) by adding log hazard ratios from separate nonlinear regressions of the four indicators, height, BMI, ABSI, and HI, against NHANES III mortality hazard. ARI far outperforms any of the individual indicators as a linear mortality predictor in NHANES III. The superior performance of ARI also holds for predicting mortality hazard in the independent Atherosclerosis Risk in Communities (ARIC) cohort. Thus, HI, along with BMI and ABSI, can capture the risk profile associated with body size and shape. These can be combined in a risk indicator that utilizes complementary information from height, weight, and waist and hip circumference. The combined ARI is promising for further research and clinical applications.

show abstract

Section: Methodsmentioning

confidence: 99%

An Anthropometric Risk Index Based on Combining Height, Weight, Waist, and Hip Measurements

Krakauer

Krakauer²

2016

Journal of Obesity

117

View full text Add to dashboard Cite

show abstract

“…The low levels of vitamin D in these studies may be due to different confounding factors such as environment, age, sex, socioeconomic status, and nutritional status. Daraghmeh et al [24] conducted an NHANES III follow-up study on extended mortality and found that low vitamin D levels are inversely associated with CAD and all-cause mortality adjusting for multiple confounders. In animals, Assalin et al [25] studied the effect of vitamin D deficiency on cardiac metabolism, morphology, and function using male weanling Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

118

View full text Add to dashboard Cite

Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

show abstract

“…lead, hydrocarbons, polychlorinated biphenyls) and blood nutrients (eg. carotenoids, Vitamin D, folate, and Vitamin E) that appear to substantially modify the prevalence of periodontitis in the population [146–151] (Figure 3B). Moreover, dietary polyphenols in a wide range of foods have also been shown to function via anti-inflammatory and antioxidant mechanisms [152], thus having the potential to impact various mechanisms to reduce the initiation and progression of periodontitis.…”

Section: The Exposome and Nutritional Immunology Of Aging And Periodomentioning

confidence: 99%

Age and Periodontal Health—Immunological View

Ebersole

Dawson

Huja

et al. 2018

Curr Oral Health Rep

View full text Add to dashboard Cite

Purpose of the Review: Aging clearly impacts a wide array of systems, in particular the breadth of the immune system leading to immunosenescence, altered immunoactivation, and coincident inflammaging processes. The net result of these changes leads to increased susceptibility to infections, increased neoplastic occurrences, and elevated frequency of autoimmune diseases with aging. However, as the bacteria in the oral microbiome that contribute to the chronic infection of periodontitis is acquired earlier in life, the characteristics of the innate and adaptive immune systems to regulate these members of the autochthonous microbiota across the lifespan remains ill defined. Recent Findings: Clear data demonstrate that both cells and molecules of the innate and adaptive immune response are adversely impacted by aging, including in the oral cavity, yielding a reasonable tenet that the increased periodontitis noted in aging populations is reflective of the age-associated immune dysregulation. Additionally, this facet of host-microbe interactions and disease needs to accommodate the population variation in disease onset and progression, which may also reflect an accumulation of environmental stressors and/or decreased protective nutrients that could function at the gene level (ie. epigenetic) or translational level for production and secretion of immune system molecules. Summary: Finally, the majority of studies of aging and periodontitis have emphasized the increased prevalence/severity of disease with aging, all based upon chronological age. However, evolving areas of study focusing on “biological aging” to help account for population variation in disease expression, may suggest that chronic periodontitis represents a co-morbidity that contributes to “gerovulnerability” within the population.

show abstract

Evidence for the vitamin D hypothesis: The NHANES III extended mortality follow-up

Cited by 32 publications

References 19 publications

An Anthropometric Risk Index Based on Combining Height, Weight, Waist, and Hip Measurements

An Anthropometric Risk Index Based on Combining Height, Weight, Waist, and Hip Measurements

Role of Vitamin D in Cardiovascular Diseases

Age and Periodontal Health—Immunological View

Contact Info

Product

Resources

About