Evidence for the transmission of antimicrobial resistant bacteria between humans and companion animals: A scoping review

Mu, Jin; Osman, Marwan; Green, B.; Yang, Yufan; Ahuja, Anuj; Liu, Zhengyu; Cazer, Casey L.

doi:10.1016/j.onehlt.2023.100593

Cited by 14 publications

(4 citation statements)

References 27 publications

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“…These recognitions warrant immediate attention for the development of innovative therapeutic strategies to address the challenges P. aeruginosa and many other dangerous antibiotic-resistant bacterial pathogens pose (Jin et al. 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Successful phage-antibiotic therapy of P. aeruginosa implant-associated infection in a Siamese cat

Braunstein,

Hubanic,

Yerushalmy

et al. 2024

Veterinary Quarterly

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Antibiotic-resistant pathogens are a growing global issue, leading to untreatable infectious diseases in both humans and animals. Personalized bacteriophage (phage) therapy, the use of specific anti-bacterial viruses, is currently a leading approach to combat antibiotic-resistant infections. The implementation of phage therapy has primarily been focused on humans, almost neglecting the impact of such infections on the health and welfare of companion animals. Pets also have the potential to spread resistant infections to their owners or the veterinary staff through zoonotic transmission. Here, we showcase personalized phage-antibiotic treatment of a cat with a multidrug-resistant Pseudomonas aeruginosa implant-associated infection post-arthrodesis surgery. The treatment encompassed a tailored combination of an anti- P. aeruginosa phage and ceftazidime, precisely matched to the pathogen. The phage was topically applied to the surgical wound while the antibiotic was administered intramuscularly. After two treatment courses spanning 7 and 3 weeks, the surgical wound, which had previously remained open for five months, fully closed. To the best of our knowledge, this is the first case of personalized phage therapy application in felines, which provides further evidence of the effectiveness of this approach. The successful outcome paves the way for personalized phage-antibiotic treatments against persistent infections therapy in veterinary practice.

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Section: Introductionmentioning

confidence: 99%

Successful phage-antibiotic therapy of P. aeruginosa implant-associated infection in a Siamese cat

Braunstein,

Hubanic,

Yerushalmy

et al. 2024

Veterinary Quarterly

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“…aureus have been described as the most common zoonotic microorganisms involved in spread between human and pets [ 16 ]. S. aureus has been usually linked to cases of human-to-companion animal transmission, while P. multocida and S. pseudintermedius are most frequently found in cases of pet-to-human zoonoses [ 16 ]. Both pathogens have been linked to various clinically relevant antimicrobial resistant phenotypes.…”

Section: Introductionmentioning

confidence: 99%

“…The public health, or One Health, concern associated with the presence of AMR and MDR pathogens lies in the zoonotic potential of some of the most common bacteria isolated from cases of canine otitis externa. P. multocida, S. pseudintermedius and Staphylococcus (S.) aureus have been described as the most common zoonotic microorganisms involved in spread between human and pets [16]. S. aureus has been usually linked to cases of human-to-companion animal transmission, while P. multocida and S. pseudintermedius are most frequently found in cases of pet-to-human zoonoses [16].…”

Section: Introductionmentioning

confidence: 99%

“…P. multocida, S. pseudintermedius and Staphylococcus (S.) aureus have been described as the most common zoonotic microorganisms involved in spread between human and pets [16]. S. aureus has been usually linked to cases of human-to-companion animal transmission, while P. multocida and S. pseudintermedius are most frequently found in cases of pet-to-human zoonoses [16]. Both pathogens have been linked to various clinically relevant antimicrobial resistant phenotypes.…”

Section: Introductionmentioning

confidence: 99%

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Microbiological Survey and Evaluation of Antimicrobial Susceptibility Patterns of Microorganisms Obtained from Suspect Cases of Canine Otitis Externa in Gran Canaria, Spain

Rosales,

Ramírez,

Moya-Gil

et al. 2024

Animals

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A retrospective study of microbiological laboratory results from 2020 to 2022, obtained from a veterinary diagnostic laboratory of the island of Gran Canaria, Spain, focused on canine otitis cases, was performed. The objective of this study was to analyze the pathogen distribution, antimicrobial susceptibility, prevalence of multidrug resistant phenotypes and the role of coinfections in otitis cases in order to provide up-to-date evidence that could support effective control strategies for this prevalent pathology. A total of 604 submissions were processed for the diagnosis of canine external otitis. Of the samples analyzed, 472 were positive for bacterial or fungal growth (78.1%; 95% CI: 74.8–81.4%). A total of 558 microbiological diagnoses were obtained, divided in 421 bacterial (75.4%; 95% CI: 71.8–79.0%) and 137 fungal (24.6%; 95% CI: 20.9–28.1%) identifications. Staphylococcus pseudintermedius, Malassezia pachydermatis and Pseudomonas aeruginosa were the most prevalent microorganisms detected in clinical cases of otitis. High level antimicrobial resistance was found for Pseudomonas aeruginosa (30.7%), Proteus mirabilis (29.4%), Staphylococcus pseudintermedius (25.1%) and Escherichia coli (19%). Multidrug-resistant phenotypes were observed in 47% of the bacteria isolated. In addition, a 26.4% prevalence of methicillin-resistant Staphylococcus pseudintermedius was detected. The high prevalence of antimicrobial resistant phenotypes in these bacteria highlights the current necessity for constant up-to-date prevalence and antimicrobial susceptibility data that can support evidence-based strategies to effectively tackle this animal and public health concern.

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Genomic analysis of the first multidrug-resistant ESBL-producing high-risk clonal lineage Klebsiella pneumoniae ST147 isolated from a cat with urinary tract infection

Sakauchi,

Haisi,

Araújo Júnior

et al. 2024

Vet Res Commun

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Evidence for the transmission of antimicrobial resistant bacteria between humans and companion animals: A scoping review

Cited by 14 publications

References 27 publications

Successful phage-antibiotic therapy of P. aeruginosa implant-associated infection in a Siamese cat

Successful phage-antibiotic therapy of P. aeruginosa implant-associated infection in a Siamese cat

Microbiological Survey and Evaluation of Antimicrobial Susceptibility Patterns of Microorganisms Obtained from Suspect Cases of Canine Otitis Externa in Gran Canaria, Spain

Genomic analysis of the first multidrug-resistant ESBL-producing high-risk clonal lineage Klebsiella pneumoniae ST147 isolated from a cat with urinary tract infection

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