Evidence for the resistance of thyrotropin-releasing hormone (TRH) and pseudo-hormone, pyroglutamyl-histidyl-amphetamine, to degradation by enzymes of the digestive tract in vitro

Masson, M.; Moreau, Odile; Debuire, Brigitte; Han, Kia‐Ki; Morier, E.; Rips, Richard

doi:10.1016/s0300-9084(79)80279-5

Cited by 14 publications

(2 citation statements)

References 10 publications

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“…The former is a decapeptide with blocked termini, i.e. pyroglutamate at the N-terminus and amidated glycine at the C-terminus, which render the molecule relatively resistant to enzymic hydrolysis (Masson et al, 1979). Its amidated N-terminal tripeptide fragment is also active on oral administration (Amoss et al, 1972).…”

Section: Evidence For Absorption Of Intact Peptidesmentioning

confidence: 99%

Entry of Peptides of Dietary Origin into the Circulation

Gardner

1983

Nutr Health

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Current theories of protein digestion and absorption state that free amino acids are the only significant form in which amino-N crosses the intestine and enters the systemic circulation. Nevertheless, there is now abundant evidence that intact peptides escaping digestion (or undergoing only partial digestion) and even whole protein molecules can enter the circulation in health and disease. Since peptides are now believed to play a major role in neural and endocrine regulation and in view of the fact that intestinal digestive activity can be reduced and intestinal 'permeability' increased in a variety of pathological conditions, the possibility that absorbed intact peptides can exert biological activities in peripheral tissues and can elicit symptoms in susceptible individuals now requires critical evaluation. These considerations may provide a physiological rationale for changing the source(s) of dietary protein in cases where food allergies/dietary sensitivities are suspected.

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Section: Evidence For Absorption Of Intact Peptidesmentioning

confidence: 99%

Entry of Peptides of Dietary Origin into the Circulation

Gardner

1983

Nutr Health

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“…Roberts et al (15) concluded that short peptides generated in the diet can be absorbed intact through the intestine and probably play a role in the modulation of organ functions and disease. Moreover, evidence has been reported on the resistance to degradation during digestion of forms containing pyroglutamic acid at the N terminus (16). Because of that, the products of the investigated reactions could have effects at the metabolic level.…”

Section: Discussionmentioning

confidence: 99%

Pressure/Temperature Combined Treatments of Precursors Yield Hormone-like Peptides with Pyroglutamate at the N Terminus

García¹,

Butz²,

Trierweiler³

et al. 2003

J. Agric. Food Chem.

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Peptides containing the cyclic product of glutamine at the N terminus are usually biologically active. If the cyclization of glutamine was associated with a volume reduction, pressure should displace the equilibrium in the direction of the lower volume. Here, results in model solutions and in whey are discussed, showing that the theorized cyclization of glutamine in Gln-His-ProNH(2) or Gln-Leu-ProNH(2) is significantly accelerated during the application of heat and even more strongly when elevated temperature and pressure combinations are used. The reaction rate depended on the intensity of the pressure treatment, the pH, and the nature of the amino acids adjacent to glutamine. The products of the reaction were identified as thyrotropin-releasing hormone (TRH) and [Leu(2)]TRH. The reported reactions could affect the naturally balanced concentration of short-chain peptides in foods and therefore induce unpredictable biological effects.

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Food peptides. A new class of hormones?

Morley¹

1982

JAMA: The Journal of the American Medical Association

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Evidence for the resistance of thyrotropin-releasing hormone (TRH) and pseudo-hormone, pyroglutamyl-histidyl-amphetamine, to degradation by enzymes of the digestive tract in vitro

Cited by 14 publications

References 10 publications

Entry of Peptides of Dietary Origin into the Circulation

Entry of Peptides of Dietary Origin into the Circulation

Pressure/Temperature Combined Treatments of Precursors Yield Hormone-like Peptides with Pyroglutamate at the N Terminus

Food peptides. A new class of hormones?

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