Evidence for the presence of arsenobetaine and another organoarsenical in shrimps

Norin, Harald; Christakopoulos, Alexandros

doi:10.1016/0045-6535(82)90152-7

Cited by 109 publications

(30 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arsenocholine, a rather elusive member of the marine arsenic cycle, was reported to be present in shrimp, 5,27 lobsters, 28 mussels 27,29 and fish. 2,27 Arsenocholine represented 0.5-9% of the extractable arsenic in the livers of marine mammals.…”

Section: Arsenocholinementioning

confidence: 99%

Determination of arsenic compounds in marine mammals with high-performance liquid chromatography and an inductively coupled plasma mass spectrometer as element-specific detector

Goessler

Rudorfer

Mackey

et al. 1998

Appl. Organometal. Chem.

View full text Add to dashboard Cite

Total arsenic concentrations and the concentrations of individual arsenic compounds were determined in liver samples of pinnipeds [nine ringed seals (Phoca hispida), one bearded seal (Erginathus barbatus)] and cetaceans [two pilot whales (Globicephalus melas), one beluga whale (Deliphinapterus leucus)]. Total arsenic concentrations ranged from 0.167 to 2.40 mg As kg−1 wet mass. The arsenic compounds extracted from the liver samples with a methanol/water mixture (9:1, v/v) were identified and quantified by anion‐ and cation‐exchange chromatography. An ICP–MS equipped with a hydraulic high‐pressure nebulizer served as the arsenic‐specific detector. Arsenobetaine (0.052–1.67 mg As kg−1 wet mass) was the predominant arsenic compound in all the liver samples. Arsenocholine was present in all livers (0.005–0.044 mg As kg−1 wet mass). The tetramethylarsonium cation was detected in all pinnipeds (<0.009 to 0.043 mg As kg−1) but not in any of the cetaceans. The concentration of dimethylarsinic acid ranged from < 0.001 to 0.109 mg As kg−1 wet mass. Most of the concentrations for methylarsonic acid (<0.001 to 0.025 mg As kg−1 wet mass) were below the detection limit. Arsenous acid and arsenic acid concentrations were below the detection limit of the method (0.001 mg As kg−1). An unknown arsenic compound was present in all liver samples at concentrations from 0.002–0.027 mg As kg−1. © 1998 John Wiley & Sons, Ltd.

show abstract

Section: Arsenocholinementioning

confidence: 99%

Determination of arsenic compounds in marine mammals with high-performance liquid chromatography and an inductively coupled plasma mass spectrometer as element-specific detector

Goessler

Rudorfer

Mackey

et al. 1998

Appl. Organometal. Chem.

View full text Add to dashboard Cite

show abstract

“…4,18 They are further methylated and converted to trimethyl arsenic compounds, including AsCho, in marine animals. 5,6 It was reported that AsCho had a weak, but significant, in vivo acute toxicity in mice, 7 but we recently demonstrated that AsCho had no in vitro cytolethality on cultured mouse splenocytes, thymocytes, Peyer's patch lymphocytes, macrophages and bone marrow cells. 1,8,9 In this study, we examined whether AsCho has any in vivo immunotoxicity, and found that it was slightly, but significantly, immunotoxic in vivo.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, it is necessary to investigate the effects of organic arsenic compounds contained in marine animals on living systems; however, there have only been a few reports about them, because insufficient amounts of pure compounds for biological experiments have been obtained. Norin and Christakopoulos 5 and Shiomi et al 6 found a minor water-soluble trimethyl arsenic compound, namely arsenocholine (AsCho), from some kinds of shrimp 5 and conch. 6 The chemical structure of this trimethyl arsenic compound was the trimethyl(2-hydroxyethyl)arsonium cation.…”

Section: Introductionmentioning

confidence: 99%

“…6 The chemical structure of this trimethyl arsenic compound was the trimethyl(2-hydroxyethyl)arsonium cation. 5 The effects of AsCho on living systems using synthesized pure material have been examined. AsCho had a weak but significant acute toxicity in murine models; the LD 50 values of AsCho on mice were 187 mg kg −1 or 6.54 g kg −1 when administered intravenously or orally respectively.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation ofin vivo acute immunotoxicity of arsenocholine, a trimethyl arsenic compound in seafood

Sakurai

Ochiai

Kojima

et al. 2005

Appl. Organometal. Chem.

View full text Add to dashboard Cite

In this study, we observed the first in vivo acute immunotoxicity of a trimethyl(2-hydroxyethyl)arsonium cation, namely arsenocholine (AsCho), which is present in marine animals that are ingested daily as seafood in many countries. It has been reported that AsCho has significant acute in vivo toxicity. A high dose of the synthetic pure AsCho was administered to CDF 1 mice intraperitoneally (0.1 g kg −1 mouse weight) or orally (a total of 10.0 g kg −1 mouse weight); its effect on the immune organs and immune effector cells was assessed. Administered AsCho, especially via the oral route, showed weak and partial, but significant, in vivo immunotoxicity in mice, although it did not cause any severe acute inflammatory responses.

show abstract

“…Methods used include TLC-AAS [44,143], paper chromatography-AAS [ 1441, paper electrophoresis-AAS [ 1451, ion exchange column chromatography-AAS for the separation and detection of arsenic(III), arsenic(V), MMAA, DMAA [146,147], GC with flame ionization detection (FID) and GC-MS of methylthioglycolate derivatives of MMAA and DMAA [148]. GC-MIP and GC alkali flame ionization for the estimation of the ethylene glycol derivative of MMAA [149], GC-FID and flame spectrometric detection of the trimethyl-silyl [150] and GC-electron capture detection of the diethyldithiocarbamate complex of MMAA and DMAA [150]; solvent extraction followed by detection by AAS [ 15 1,1521, and polarography/voltammetry to discriminate arsenic(II1) and arsenic(V) [ 153,1543.…”

Section: Other Methodsmentioning

confidence: 99%

Determination of arsenic species in biological and environmental samples (Technical Report)

Morita¹,

Edmonds²

1992

Pure and Applied Chemistry

View full text Add to dashboard Cite

show abstract

Evidence for the presence of arsenobetaine and another organoarsenical in shrimps

Cited by 109 publications

References 16 publications

Determination of arsenic compounds in marine mammals with high-performance liquid chromatography and an inductively coupled plasma mass spectrometer as element-specific detector

Determination of arsenic compounds in marine mammals with high-performance liquid chromatography and an inductively coupled plasma mass spectrometer as element-specific detector

Evaluation ofin vivo acute immunotoxicity of arsenocholine, a trimethyl arsenic compound in seafood

Determination of arsenic species in biological and environmental samples (Technical Report)

Contact Info

Product

Resources

About