Evidence for the involvement of the serotonergic 5-HT1A receptors in the antidepressant-like effect caused by hesperidin in mice

Souza, Leandro Cattelan; Gomes, Marcelo Gomes de; Goes, André Tiago Rossito; Fabbro, Lucian Del; Filho, Carlos Borges; Boeira, Silvana Peterini; Jessé, Cristiano Ricardo

doi:10.1016/j.pnpbp.2012.09.003

Cited by 81 publications

(54 citation statements)

References 50 publications

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“…25,26 Hence, the synergistic action of the K + channel blockers and hesperidin in the TST could be dependent on the activation of the serotonergic system, particularly by an interaction with the 5-HT 1A receptors. This hypothesis is in agreement with the data presented by Souza et al, 5 which demonstrated that the administration of pCPA (an inhibitor of 5-HT synthesis) and WAY100635 (a selective 5-HT 1A receptor antagonist) prevented the antidepressant-like effect of hesperidin in the mice TST.…”

Section: Discussionsupporting

confidence: 93%

“…The choice of the doses of hesperidin was based on published data and on preliminary experiments. [5][6][7]15 Drugs were administered intraperitoneally (i.p.) in a constant volume of 10 mL/kg body weight.…”

Section: Drugs and Treatmentmentioning

confidence: 99%

“…4 The potential therapeutic value of hesperidin for depression has been increasingly demonstrated by our initial research; it has exhibited antidepressant-like effect in mice, possibly dependent on the interaction with the serotonergic 5-HT 1A and kappa-opioid receptors. 5,6 Furthermore, our recent findings suggest that acute and chronic treatment with hesperidin produces an antidepressant-like effect by a mechanism that modulates the inhibition of the l-argininenitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. This effect may also be partially mediated through the increase of hippocampal brain-derived neurotrophic factor levels.…”

Section: Introduction Dmentioning

confidence: 99%

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Evidence for the Involvement of Potassium Channel Inhibition in the Antidepressant-Like Effects of Hesperidin in the Tail Suspension Test in Mice

Donato

Filho

Giacomeli

et al. 2015

Journal of Medicinal Food

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The administration of hesperidin elicits an antidepressant-like effect in mice by a mechanism dependent on an interaction with the l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway, whose stimulation is associated with the activation of potassium (K + ) channels. Thus, this study investigated the involvement of different types of K + channels in the antidepressant-like effect of hesperidin in the mice tail suspension test (TST). The intracerebroventricular administration of tetraethylammonium (TEA, a nonspecific blocker of K + channels), glibenclamide (an ATP-sensitive K + channel blocker), charybdotoxin (a large-and intermediate-conductance calcium-activated K + channel blocker) or apamin (a small-conductance calcium-activated K + channel blocker) combined with a subeffective dose of hesperidin (0.01 mg/kg, intraperitoneally [i.p.]) was able to produce a synergistic antidepressant-like effect in the mice TST. Moreover, the antidepressant-like effect elicited by an effective dose of hesperidin (0.3 mg/kg, i.p.) in TST was abolished by the treatment of mice with pharmacological compounds K + channel openers (cromakalim and minoxidil). Results showed that the antidepressantlike effect of hesperidin in TST may involve, at least in part, the modulation of neuronal excitability through inhibition of K + channels and may act through a mechanism dependent on the inhibition of l-arginine-NO pathway.

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Section: Discussionsupporting

confidence: 93%

Section: Drugs and Treatmentmentioning

confidence: 99%

Section: Introduction Dmentioning

confidence: 99%

See 1 more Smart Citation

Evidence for the Involvement of Potassium Channel Inhibition in the Antidepressant-Like Effects of Hesperidin in the Tail Suspension Test in Mice

Donato

Filho

Giacomeli

et al. 2015

Journal of Medicinal Food

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“…In this study they attributed the effect to the presence of phenols in the extract, such as epicatechin (flavonol) and chlorogenic acid. Flavonoids, a large part of polyphenols obtained from plants, are speculated to be effective in the treatment of several CNS disorders such as depression (Donato et al 2014, Souza et al 2013). In addition, evidence suggests that natural products rich in flavonoids, which increase the BDNF levels, are promising therapeutic targets for the treatment of depression (Stringer et al 2015).…”

Section: Resultsmentioning

confidence: 99%

Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats

Dani

Andreazza

Gonçalves

et al. 2017

An. Acad. Bras. Ciênc.

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Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.

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“…Hesperidin has been reported to exhibit antidepressant activity at acute and chronic doses of 0.1, 0.3 or 1 mg/ kg, i.p., and this effect appeared to be mediated by the inhibition of l-arginine-NO-cGMP pathway and elevation of BDNF levels in hippocampus [20] . The antidepressant activity of hesperidin has been reported at the doses of 0.1, 0.3 or 1 mg/kg, i.p., using FST and tail suspension test via interaction with the κ-opioid receptor and serotonergic 5-HT(1A) receptors [21,22] . In an another study, antidepressant activity of hesperidin was reported at the dose of 0.7 mg/kg, i.p.…”

Section: Resultsmentioning

confidence: 99%

Screening of Antidepressant Activity and Marker-based Standardization of Baptisia tinctoria (L.) R. Vent.

Kumar¹,

Kumar²

2017

pharmaceutical-sciences

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Richa and Kumar: Antidepressant Activity and TLC Densitometry of Baptisia tinctoriaBaptisia tinctoria (Wild indigo; Fabaceae) has long tradition of use in Indian systems of medicine for the treatment of depression. This investigation deals with the evaluation of the antidepressant activity of various extracts and fractions of B. tinctoria roots and estimation of the content of bioactive principle using thin-layer chromatography densitometry. Roots of B. tinctoria were successively extracted to obtain n-hexane, chloroform, methanol and water extracts. The chloroform, methanol and water extracts were screened for antidepressant activity at doses of 200 or 400 mg/kg, p.o., in mice subjected to forced swim test. Methanol extract showed significant activity at a dose of 400 mg/kg. The methanol extract was further fractionated successively to obtain ethyl acetate and 1-butanol fractions. Antidepressant activity of these fractions was assessed using forced swim test at the doses of 90 and 80 mg/kg, p.o., respectively. The ethyl acetate fraction showed significant antidepressant activity at the dose of 90 mg/kg in mice. Further, specific antidepressant activity without psychostimulant effects of bioactive methanol extract and ethyl acetate fraction was confirmed through evaluation of locomotor behaviour in mice using open field test. Phytochemical screening showed the presence of flavonoids as major class of phytoconstituents in the methanol extract. Comparative thin-layer chromatography fingerprint studies confirmed the presence of hesperitin in methanol extract. Hesperitin was used as a chemical marker to standardize B. tinctoria roots using validated thin-layer chromatography densitometric method and the content of hesperitin was found to be 0.0085% w/w.

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Evidence for the involvement of the serotonergic 5-HT1A receptors in the antidepressant-like effect caused by hesperidin in mice

Cited by 81 publications

References 50 publications

Evidence for the Involvement of Potassium Channel Inhibition in the Antidepressant-Like Effects of Hesperidin in the Tail Suspension Test in Mice

Evidence for the Involvement of Potassium Channel Inhibition in the Antidepressant-Like Effects of Hesperidin in the Tail Suspension Test in Mice

Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats

Screening of Antidepressant Activity and Marker-based Standardization of Baptisia tinctoria (L.) R. Vent.

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