Evidence for the gut‐skin axis: Common genetic structures in inflammatory bowel disease and psoriasis
Jinyan Guo,
Qinghua Luo,
Chunsheng Li
et al.
Abstract:BackgroundInflammatory bowel disease (IBD) and psoriasis (Ps) are common immune‐mediated diseases that exhibit clinical comorbidity, possibly due to a common genetic structure. However, the exact mechanism remains unknown.MethodsThe study population consisted of IBD and Ps genome‐wide association study (GWAS) data. Genetic correlations were first evaluated. Then, the overall evaluation employed LD score regression (LDSC), while the local assessment utilized heritability estimation from summary statistics (HESS… Show more
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