Evidence for the effect of antibodies to TSH receptors on the thyroid ultrasonographic volume in patients with Graves' disease

Rieu, M; Raynaud, A; Richard, A; Laplanche, Sophie; Sambor, B; Jl, Berrod

doi:10.1111/j.1365-2265.1994.tb01834.x

Cited by 12 publications

(5 citation statements)

References 31 publications

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“…Rieu M in his study (11) shows that hormonal status modulates the appearance of thyroid autoimmunity, by concluding that there exists a significant correlation between some hormonal parameters and TRAb (T3, r = 0.42, P < 0.001; T4, r = 0.48, p < 0.001) at patients with Graves’ diseases, something that was also shown in this study.…”

Section: Discussionsupporting

confidence: 80%

Association Between Autoantibodies Against Thyroid Stimulating Hormone Receptor and Thyroid Diseases

Latifi-Pupovci¹

2014

Med Arh

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Aim:The aim of this study is to determine the relationship between TRAb and different diseases. The highest percentage of increased TRAb levels can be found at patients with Graves’ diseases.Material and methods:Study was performed in 70 patients, grouped in three groups, and 14 persons who based on the clinical status and the levels of thyroid hormones do not have any thyroid disease. The TRAb levels has been determined in patients with Graves’ disease (N=40), Hashimoto’s disease (N=15), Plummer’s disease (N=15) and the control group (N=14).Results:The highest mean TRAb levels exist in patients with Graves’ disease. There exists a positive correlation between TRAb levels and T3, and T4, while there is no correlation between TSH and TRAb levels in patients with Graves’ disease,. On the other hand, the correlation between TRAb and T3 and T4 in patients with Hashimoto’s diseases and Plummers disease was shown to be positive, but of a low levels.

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Section: Discussionsupporting

confidence: 80%

Association Between Autoantibodies Against Thyroid Stimulating Hormone Receptor and Thyroid Diseases

Latifi-Pupovci¹

2014

Med Arh

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“…In a study by Edan and coworkers (13), 44 of 64 patients tested every 3 months in whom therapy was stopped when TRAb (TSAb) became negative were maintained on antithyroid drug for an average of 9 months (range, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Among them, the relapse rate was 41% compared to a rate of 92% for the patients who remained TSAb-positive after 18 months of antithyroid drug treatment (13).…”

Section: Modalities Of Antithyroid Drug Therapymentioning

confidence: 99%

Reduction of the Risk of Relapse After Withdrawal of Medical Therapy for Graves' Disease

Orgiazzi

Madec

2002

Thyroid

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It has been a continuing challenge to try and identify those patients with hyperthyroid Graves' disease likely to remain in remission after an antithyroid drug course or to manage the medical treatment so as to increase the chance of remission. On average, the overall relapse rate is approximately 50% and any significant reduction of this figure would be of practical as well as theoretical value. The numerous controlled prospective studies performed in many parts of the world, with varying iodine intakes, have all confirmed that the main initial features related to the subsequent risk of relapse are: young age, male gender, goiter larger than 40 mL, hypoechogenic and hypervascular gland, high level of anti-thyrotropin receptor antibody (TRAb), detected either with radioreceptor assay (TBII: >40 U/L) or the biologic stimulation assay (thyroid-stimulating antibodies [TSAb]; >300%), severity of hyperthyroidism, and possibly the presence of ophthalmopathy. Alone, each of these has a low predictive value, but together they allow evaluation of the risk of relapse, thus helping treatment choice. As to the modalities of antithyroid drug treatment, dose of the drug or addition of levothyroxine does not affect posttreatment outcome. In contrast, significantly fewer relapses occur for drug courses longer than at least 1 year. Persistence of high levels of TRAb after medical treatment is strongly predictive of relapse but this is of limited value because in most patients, TRAb levels are low or even undetectable at the end of treatment, which does not indicate for further outcome. Smoking is a significant independent risk factor for relapse. In conclusion, reduction of the risk of relapse in patients with medically treated hyperthyroid Graves' disease relies on clinical competence and appropriate management taking into account an array of factors none of which alone has definite predictive value.

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“…A localized thyroid area was considered nodular when it had a distinctive rim at two different incidences. When this rim was absent, a thyroid area with round or oval patterns, and also echogenicity different from that of the surrounding normal tissue, was classified as nodular (Bruneton & Normand, 1987;Rieu et al, 1994a). All the nodular images were taken into account, irrespective of size.…”

Section: Subjectsmentioning

confidence: 99%

Prevalence of sporadic medullary thyroid carcinoma: the importance of routine measurement of serum calcitonin in the diagnostic evaluation of thyroid nodules

Rieu

Lame

Richard

et al. 1995

Clinical Endocrinology

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144

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This study demonstrates a surprisingly high prevalence of sporadic forms of medullary thyroid carcinoma in patients with nodular thyroid disease. Such forms of medullary thyroid carcinoma seem to be unrelated to iodine intake and may be pure or mixed with a follicular carcinoma. In these mixed thyroid carcinomas, only the neoplastic follicular pattern was seen on both cytological and histological examination. Routine measurements of serum calcitonin levels should therefore be considered an integral part of the diagnostic evaluation of thyroid nodules. Indeed, increasing the accuracy of diagnosis of medullary thyroid carcinoma encourages the surgeon to perform more radical treatment, thus achieving more frequent normalization of post-operative serum calcitonin levels.

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Evidence for the effect of antibodies to TSH receptors on the thyroid ultrasonographic volume in patients with Graves' disease

Abstract: This study demonstrates, in vivo, that TSH receptor antibodies modulate the thyroid ultrasonographic extranodular and nodular volumes in patients with Graves' disease.

Cited by 12 publications

References 31 publications

Association Between Autoantibodies Against Thyroid Stimulating Hormone Receptor and Thyroid Diseases

Association Between Autoantibodies Against Thyroid Stimulating Hormone Receptor and Thyroid Diseases

Reduction of the Risk of Relapse After Withdrawal of Medical Therapy for Graves' Disease

Prevalence of sporadic medullary thyroid carcinoma: the importance of routine measurement of serum calcitonin in the diagnostic evaluation of thyroid nodules

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