Evidence for Synergism in Nonionic Surfactant Mixtures:  Enhancement of Solubilization in Water-in-Oil Microemulsions

Huibers, Paul D. T.; Shah, Dinesh O.

doi:10.1021/la962108r

Cited by 107 publications

(81 citation statements)

References 6 publications

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“…The monomeric solubility of lipophilic surfactant (ethoxylated mono-di-glyceride) in oil is low and its mixing with sucrose laurate enables us to attain a large solubilization capacity of water and mixed oils. According to Huibers and Shah [41] model, this confirms that the maximum water solubilization achieved using a mixture of nonionic surfactants could be due to two different synergism mechanisms. The first, the maximum water solubilization capacity, could be related to simple additive contributions of the surfactant material in the HLB 9-13 region with no apparent additional benefit from synergism between the two surfactant.…”

Section: Resultssupporting

confidence: 59%

Microemulsions with Mixed Nonionic Surfactants and Flavor Oil

Fanun

2010

J Surfact & Detergents

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The microemulsion systems composed of water/sucrose laurate/ethoxylated mono-di-glyceride/peppermint oil were formulated and characterized using electrical conductivity and small-angle X-ray scattering. The solubilization capacity of water in the oil is dependent on the surfactant mixing ratio. A static percolation phenomenon was observed in these systems and the water volume fraction percolation threshold was determined. A progressive transformation of water-in-oil to bicontinuous microemulsions, occurring upon dilution with water was revealed for equal amounts of sucrose laurate and ethoxylated mono-di-glyceride in the microemulsions. The periodicity, that is a characteristic length for the domain size of the microemulsions, increases linearly with the increase in the water volume fraction, whereas the correlation length, that is also a characteristic length for the domain size, increases with the increase in the water volume fraction up to a certain value then decreases.

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Section: Resultssupporting

confidence: 59%

Microemulsions with Mixed Nonionic Surfactants and Flavor Oil

Fanun

2010

J Surfact & Detergents

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“…Similarly, the increase in surfactant concentration also produced large droplet size, which may be the consequences of rigid interfacial film leading to improper emulsification. For proper emulsification and stability, a flexible interface with required HLB is always pre-requisite 30 . Therefore, for every kind of oil-drug mixture, a specific ratio of Smix is most desirable to obtained small droplet size and narrow size distribution.…”

Section: Droplet Diameter and Surface Chargementioning

confidence: 99%

Comparative Anti-inflammatory Potential of Crystalline and Amorphous Nano Curcumin in Topical Drug Delivery

Alrohaimi

2015

J. Oleo Sci.

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“…1). This might be due to the fact that the flexibility of surfactant layer and its ability to partition at higher levels into the oil-water interface might be enhanced by the combined surfactants; both of which stabilized o/w nanoemulsion formed (27,(46)(47)(48)(49). Moreno et al (27) reported that the combined use of Tween 80 and soybean lecithin was found to greatly increase the oil content in microemulsions by threefold.…”

Section: Construction Of Pseudoternary-phase Diagramsmentioning

confidence: 99%

Nanoemulsion as a Potential Ophthalmic Delivery System for Dorzolamide Hydrochloride

et al. 2009

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Abstract. Dilutable nanoemulsions are potent drug delivery vehicles for ophthalmic use due to their numerous advantages as sustained effect and high ability of drug penetration into the deeper layers of the ocular structure and the aqueous humor. The aim of this article was to formulate the antiglaucoma drug dorzolamide hydrochloride as ocular nanoemulsion of high therapeutic efficacy and prolonged effect. Thirty-six systems consisting of different oils, surfactants, and cosurfactants were prepared and their pseudoternary-phase diagrams were constructed by water titration method. Seventeen dorzolamide hydrochloride nanoemulsions were prepared and evaluated for their physicochemical and drug release properties. These nanoemulsions showed acceptable physicochemical properties and exhibited slow drug release. Draize rabbit eye irritation test and histological examination were carried out for those preparations exhibiting superior properties and revealed that they were nonirritant. Biological evaluation of dorzolamide hydrochloride nanoemulsions on normotensive albino rabbits indicated that these products had higher therapeutic efficacy, faster onset of action, and prolonged effect relative to either drug solution or the market product. Formulation of dorzolamide hydrochloride in a nanoemulsion form offers, thus, a more intensive treatment of glaucoma, a decrease in the number of applications per day, and a better patient compliance compared to conventional eye drops.

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Evidence for Synergism in Nonionic Surfactant Mixtures: Enhancement of Solubilization in Water-in-Oil Microemulsions

Cited by 107 publications

References 6 publications

Microemulsions with Mixed Nonionic Surfactants and Flavor Oil

Microemulsions with Mixed Nonionic Surfactants and Flavor Oil

Comparative Anti-inflammatory Potential of Crystalline and Amorphous Nano Curcumin in Topical Drug Delivery

Nanoemulsion as a Potential Ophthalmic Delivery System for Dorzolamide Hydrochloride

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