Evidence for species-dependent biosynthetic pathways for converting carlactone to strigolactones in plants

Iseki, Moe; Shida, Kasumi; Kuwabara, Kazuma; Wakabayashi, Takatoshi; Mizutani, Masaharu; Takikawa, Hirosato; Sugimoto, Yukihiro

doi:10.1093/jxb/erx428

Cited by 45 publications

(90 citation statements)

References 29 publications

(49 reference statements)

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“…MAX3 and MAX4 encode two CCD enzymes, whose sequential actions produce carlactone from β-carotene (Alder et al, 2012;Auldridge et al, 2006;Matusova et al, 2005). According to our results, endogenous production of carlactone would be required for the expres- (Iseki et al, 2018;Seto et al, 2014).…”

Section: Specificity Of Max Mutations As Suppressors Of Tbl29mentioning

confidence: 51%

“…In contrast, MeCLA and CLA applications complement only SL‐deficient mutants but not in max2 , indicating that unlike carlactone, MeCLA/CLA perception requires MAX2 (Abe et al., ). Carlactone has been proposed as a precursor of other SL compounds, and subsequent species‐specific rearrangements and modifications catalyzed by downstream enzymes would convert carlactone into the large diversity of SL compounds found in plants (Iseki et al., ; Seto et al., ). Thus, we cannot rule out the possibility that not carlactone itself, but a carlactone‐derived, MAX1‐independent SL compound is involved in this regulation of xylem development in secondary wall‐deficient mutants.…”

Section: Discussionmentioning

confidence: 99%

“…The production of carlactone and its following conversion into carlactonic acid (in Arabidopsis likely performed by the MAX1 cytochrome P450 enzyme) seem to be a common strategy in plants. In contrast, it seems that the pathway diverges from there, and species-specific reactions transform carlactone into more than 20 canonical and non-canonical SL compounds identified in plant exudates (Al-Babili & Bouwmeester, 2015;Iseki et al, 2018;Tokunaga, Hayashi, & Akiyama, 2015). In Arabidopsis, carlactonic acid is transformed into methyl carlactonoate (MeCLA) by an unknown enzyme (Abe et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Genetic dissection of cell wall defects and the strigolactone pathway in Arabidopsis

Ramírez

Pauly

2019

Plant Direct

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Defects in the biosynthesis and/or deposition of secondary plant cell wall polymers result in the collapse of xylem vessels causing a dwarfed plant stature and an altered plant architecture termed irregular xylem ( irx ) syndrome. For example, reduced xylan O ‐acetylation causes strong developmental defects and increased freezing tolerance. Recently, we demonstrated that the irx syndrome in the trichome birefringence‐like 29/eskimo1 ( tbl29/esk1 ) mutant is dependent on MORE AXILLARY GROWTH 4 ( MAX 4), a key enzyme in the biosynthesis of the phytohormone strigolactone ( SL ). In this report, we show that other xylan‐ and cellulose‐deficient secondary wall mutants exhibit increased freezing tolerance correlated with the irx syndrome. In addition, these phenotypes are also dependent on MAX 4, suggesting a more general interaction between secondary wall defects and SL biosynthesis. In contrast, MAX 4 does not play a role in developmental defects triggered by primary wall deficiencies, suggesting that the interaction is restricted to vascular tissue. Through a reverse genetics approach, the requirement of different components of the SL pathway impacting the irx syndrome in tbl29 was evaluated. Our results show that the tbl29 ‐associated irx phenotypes are dependent on the MAX 3 and MAX 4 enzymes, involved in the early steps of SL biosynthesis. In contrast, this signaling is independent on downstream enzymes in the biosynthesis and perception of SL such as MAX 1 and MAX 2.

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Section: Specificity Of Max Mutations As Suppressors Of Tbl29mentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic dissection of cell wall defects and the strigolactone pathway in Arabidopsis

Ramírez

Pauly

2019

Plant Direct

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“…2). 32 For example, moonseed (Menispermum dauricum) could not convert 5DS to strigol in the feeding experiment, suggesting that hydroxy-CL or hydroxy-CLA is the precursor of strigol in this plant species. Fig.…”

Section: Strigolactone Biosynthetic Pathway and Its Regulationmentioning

confidence: 93%

“…Feeding experiments clearly demonstrate that hydroxy‐SLs such as strigol and orobanchol are not always synthesized from the corresponding non‐hydroxy SLs such as 5DS and 4DO (Fig. ) . For example, moonseed ( Menispermum dauricum ) could not convert 5DS to strigol in the feeding experiment, suggesting that hydroxy‐CL or hydroxy‐CLA is the precursor of strigol in this plant species.…”

Section: Strigolactone Biosynthetic Pathway and Its Regulationmentioning

confidence: 98%

Regulation of biosynthesis, perception, and functions of strigolactones for promoting arbuscular mycorrhizal symbiosis and managing root parasitic weeds

Yoneyama

Xie

Yoneyama

et al. 2019

Pest Management Science

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Strigolactones (SLs) are carotenoid‐derived plant secondary metabolites that play important roles in various aspects of plant growth and development as plant hormones, and in rhizosphere communications with symbiotic microbes and also root parasitic weeds. Therefore, sophisticated regulation of the biosynthesis, perception and functions of SLs is expected to promote symbiosis of beneficial microbes including arbuscular mycorrhizal (AM) fungi and also to retard parasitism by devastating root parasitic weeds. We have developed SL mimics with different skeletons, SL biosynthesis inhibitors acting at different biosynthetic steps, SL perception inhibitors that covalently bind to the SL receptor D14, and SL function inhibitors that bind to the serine residue at the catalytic site. In greenhouse pot tests, TIS108, an azole‐type SL biosynthesis inhibitor effectively reduced numbers of attached root parasites Orobanche minor and Striga hermonthica without affecting their host plants; tomato and rice, respectively. AM colonization resulted in weak but distinctly enhanced plant resistance to pathogens. SL mimics can be used to promote AM symbiosis and to reduce the application rate of systemic‐acquired resistance inducers which are generally phytotoxic to horticultural crops. © 2019 Society of Chemical Industry

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Discovery of strigol synthase from cotton (Gossypium hirsutum): The enzyme behind the first identified germination stimulant for Striga

Wakabayashi

Nakayama

Kitano

et al. 2023

Plants People Planet

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Societal Impact StatementParasitic witchweeds (Striga species) pose a serious threat to food security in Africa, attacking cereal grains and legumes. Chemicals released from the host roots that initiate the life cycle of Striga are known as germination stimulants, predominantly strigolactones (SLs). Strigol, the first identified SL, was isolated from the root exudates of cotton (Gossypium hirsutum), a false host of Striga, over 50 years ago. The identification of strigol synthase in cotton establishes the complete biosynthesis pathway of this emblematic SL. This discovery has the potential to advance our understanding of SL‐mediated rhizosphere interactions and enhance cotton's effectiveness as a trap crop.

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Evidence for species-dependent biosynthetic pathways for converting carlactone to strigolactones in plants

Abstract: Strigolactones, a novel class of phytohormones, regulate plant architecture and act as rhizosphere signals. Species-specific biosynthetic pathways convert a common precursor, carlactone, to strigolactones.

Cited by 45 publications

References 29 publications

Genetic dissection of cell wall defects and the strigolactone pathway in Arabidopsis

Genetic dissection of cell wall defects and the strigolactone pathway in Arabidopsis

Regulation of biosynthesis, perception, and functions of strigolactones for promoting arbuscular mycorrhizal symbiosis and managing root parasitic weeds

Discovery of strigol synthase from cotton (Gossypium hirsutum): The enzyme behind the first identified germination stimulant for Striga

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