Evidence for reduced somatosensory lateralisation and focalisation in schizophrenia

White, Thomas P.; Francis, Susan T.; Joseph, Verghese; O’Regan, Eileen; Head, Kevin; Liddle, Peter F.

doi:10.1016/j.pscychresns.2009.04.004

Cited by 14 publications

(4 citation statements)

References 31 publications

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“…However, those conditions in which the right finger moved induced sensation on the moving hand. While it appears that SII responds bilaterally to unilateral peripheral stimulation, it has been shown previously that SII response is lateralised to the hemisphere contralateral to response (White et al, 2009), and as such our investigation of right-hemispheric SII effects can be reasonably asserted to reflect tactile responses of the left index finger. Nevertheless, these considerations highlight the complexity of studying sensorimotor prediction using bimanual interactions.…”

Section: Discussionmentioning

confidence: 50%

Modulation of somatosensory processing by action

Shergill¹,

White²,

Joyce³

et al. 2013

NeuroImage

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Psychophysical evidence suggests that sensations arising from our own movements are diminished when predicted by motor forward models and that these models may also encode the timing and intensity of movement. Here we report a functional magnetic resonance imaging study in which the effects on sensation of varying the occurrence, timing and force of movements were measured. We observed that tactile-related activity in a region of secondary somatosensory cortex is reduced when sensation is associated with movement and further that this reduction is maximal when movement and sensation occur synchronously. Motor force is not represented in the degree of attenuation but rather in the magnitude of this region's response. These findings provide neurophysiological correlates of previously-observed behavioural forward-model phenomena, and advocate the adopted approach for the study of clinical conditions in which forward-model deficits have been posited to play a crucial role.

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Section: Discussionmentioning

confidence: 50%

Modulation of somatosensory processing by action

Shergill¹,

White²,

Joyce³

et al. 2013

NeuroImage

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“…42,43 The altered activation of S1/S2 suggests that somatosensory stimuli might be processed in a less anatomically specialized manner in psychotic spectrum disorders compared to controls. 20,21,44 However, given the findings of reduced N2/P2 amplitude and pain perception in our SCZ and-at least to some extent-BD-I samples,…”

Section: Discussionmentioning

confidence: 60%

“…The altered activation of S1/S2 suggests that somatosensory stimuli might be processed in a less anatomically specialized manner in psychotic spectrum disorders compared to controls . However, given the findings of reduced N2/P2 amplitude and pain perception in our SCZ and—at least to some extent—BD‐I samples, an alternative explanation could be that the sensory input that reached the somatosensory areas may be reduced (e.g., through a top‐down modulation) in these patients, thus resulting in reduced N1 amplitudes …”

Section: Discussionmentioning

confidence: 82%

Pain‐processing abnormalities in bipolar I disorder, bipolar II disorder, and schizophrenia: A novel trait marker for psychosis proneness and functional outcome?

et al. 2016

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“…By using these symmetrical ROIs, the laterality index (LI) was calculated [LI = (L − R)/(L + R) × 100; L = beta estimates of left hemispheric activation, R = beta estimates of right hemispheric activation]. The formula of the LI was calculated based on previous studies (Koeda et al, 2006, 2007; White et al, 2009). In calculation of LI, the beta value of each subject used was either plus or zero, and minus beta values were excluded.…”

Section: Methodsmentioning

confidence: 99%

Cerebral responses to vocal attractiveness and auditory hallucinations in schizophrenia: a functional MRI study

Koeda

Takahashi

Asai

et al. 2013

Front. Hum. Neurosci.

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Impaired self-monitoring and abnormalities of cognitive bias have been implicated as cognitive mechanisms of hallucination; regions fundamental to these processes including inferior frontal gyrus (IFG) and superior temporal gyrus (STG) are abnormally activated in individuals that hallucinate. A recent study showed activation in IFG-STG to be modulated by auditory attractiveness, but no study has investigated whether these IFG-STG activations are impaired in schizophrenia. We aimed to clarify the cerebral function underlying the perception of auditory attractiveness in schizophrenia patients. Cerebral activation was examined in 18 schizophrenia patients and 18 controls when performing Favorability Judgment Task (FJT) and Gender Differentiation Task (GDT) for pairs of greetings using event-related functional MRI. A full-factorial analysis revealed that the main effect of task was associated with activation of left IFG and STG. The main effect of Group revealed less activation of left STG in schizophrenia compared with controls, whereas significantly greater activation in schizophrenia than in controls was revealed at the left middle frontal gyrus (MFG), right temporo-parietal junction (TPJ), right occipital lobe, and right amygdala (p < 0.05, FDR-corrected). A significant positive correlation was observed at the right TPJ and right MFG between cerebral activation under FJT minus GDT contrast and the score of hallucinatory behavior on the Positive and Negative Symptom Scale. Findings of hypo-activation in the left STG could designate brain dysfunction in accessing vocal attractiveness in schizophrenia, whereas hyper-activation in the right TPJ and MFG may reflect the process of mentalizing other person's behavior by auditory hallucination by abnormality of cognitive bias.

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Evidence for reduced somatosensory lateralisation and focalisation in schizophrenia

Cited by 14 publications

References 31 publications

Modulation of somatosensory processing by action

Modulation of somatosensory processing by action

Pain‐processing abnormalities in bipolar I disorder, bipolar II disorder, and schizophrenia: A novel trait marker for psychosis proneness and functional outcome?

Cerebral responses to vocal attractiveness and auditory hallucinations in schizophrenia: a functional MRI study

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