Evidence for Recombination Between Feline Panleukopenia Virus and Canine Parvovirus Type 2

Abstract

ABSTRACT. Canine parvovirus type 2 (CPV) is a virulent pathogen that emerged in the late 1970s, probably originating from feline panleukopenia virus (FPLV) or a closely related carnivore parvovirus belonging to the feline parvovirus (FPV) subspecies. In contrast to FPLV, CPV has evolved rapidly since its emergence. The original antigenic type of CPV disappeared more than two decades ago and several new antigenic as well as genetic CPV variants have appeared and spread in the field. Both high mutation rate and positive selection of mutations in the capsid gene appear to be the driving force for such rapid evolution. In addition, genetic recombination has been assessed as a factor in parvovirus evolution. Recently, we provided the first evidence of inter-antigenic type recombination of CPV in nature. Here, an inter-FPV subspecies recombinant was revealed by analyzing the genetic data deposited in databases with several recombination detection programs, and by phylogeny. FPLV strain XJ-1, submitted by Su et al., Harbin, China in 2007 (GenBank accession no. EF988660), was most likely generated by recombination between CPV and FPLV. Its genome was generally composed of the NS1 gene of CPV origin and the VP1 gene of FPLV origin. This is the first demonstration of recombination between different FPV subspecies in nature. Consequently, recombination should be considered as an element in the generation and evolution of parvoviruses of the FPV subspecies.

Genetic variability of human metapneumo‐ and bocaviruses in children with respiratory tract infections

“…Lin et al 19 and Xu et al 20 also reported the circulation of HBoV strains belonging to a third group different from St1 and St2, which resulted from recombination events between different circulating viral strains. Such genetic recombination events have been reported in parvoviruses38,39 and in different HBoV species 40–42. Our data suggest that the strains HBoVs/Athens.GRC/35.07 and HBoVs/Athens.GRC/108.07 resulted from recombination events between a HBoVs/Athens.GRC/27.07-like and a HBoVs/Athens.GRC/24.08-like strains, with a breakpoint site in the VP1/VP2 region.…”

Genetic Characterization of a Potentially Novel Goose Parvovirus Circulating in Muscovy Duck Flocks in Fujian Province, China

“…Recombination events among HBoV2 variants have also been observed, as recently reported for animal parvoviruses [5,6,12]. On the other hand, the NS ORF of Gorilla Bocavirus species 1 (GBoV1) is more similar in length to [8]. These results possibly indicate that cross-species transmission events have been quite frequent and also show that the NS1 and capsid proteins together determine the host range of parvovirus [9,13].…”

Adeno-Associated Virus Serotype 1 (AAV1)- and AAV5-Antibody Complex Structures Reveal Evolutionary Commonalities in Parvovirus Antigenic Reactivity

“…For these two viruses, mutagenesis, cell-based assays, and cryo-reconstruction for nine capsid-Fab fragment complexes defined two regions, the mounds at the 3-fold axis (site A) and the 2/5-fold wall (site B) (Fig. 8B, D, and F), as being antigenically dominant (81)(82)(83)(84)(85). These regions also play a role in host range evolution and receptor attachment.…”