Evidence for Preferential Transfer of Prostaglandin F2α to the Ovarian Artery Following Intrauterine Administration in Cattle1

Hixon, J. E.; Hansel, William

doi:10.1095/biolreprod11.5.543

Cited by 82 publications

(34 citation statements)

References 19 publications

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“…The reason for the immediate positive progesterone response to PGF treatment is not known. Based on an in vitro study (Speroff & Ramwell 1970), a direct PGF steroidogenic stimulation of luteal cells has been suggested (Hixon & Hansel 1974). Direct inhibitory and stimulating effects of PGF on small and large luteal cells respectively have been demonstrated in vitro (Alila et al 1988, Meidan et al 1992, Girsh et al 1995, Okuda et al 1998, Skarzynski & Okuda 1999.…”

Section: Discussionmentioning

confidence: 99%

“…Several PGFM pulses may occur each day, and each pulse is several hours in duration. A dose of PGF or a PGF analogue that induces complete luteolysis with a single treatment causes an immediate transient increase in progesterone prior to the decrease (Lamond et al 1973, Hixon & Hansel 1974, Skarzynski et al 2003. The transient increase is reportedly a non-physiologic response to a pharmacologic dose of PGF in heifers (Ginther et al 2009a, Shrestha et al 2010 and mares (Ginther et al 2007a(Ginther et al , 2009c.…”

Section: Introductionmentioning

confidence: 99%

“…After the transient increase from a single bolus treatment with PGF or a PGF analogue that induces complete luteolysis, a decrease in progesterone occurs for about 1 h and may be followed by a cessation of the decrease or a transient rebound during the next few hours before continuing the decrease (Hixon & Hansel 1974, Stellflug et al 1977, Schallenberger et al 1984, Baishya et al 1994. A single dose of PGF that induces only partial luteolysis apparently does not induce an immediate transient increase, but is associated with a more prominent transient rebound than for a dose that induces complete luteolysis (Ginther et al 2009a).…”

Section: Introductionmentioning

confidence: 99%

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Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Shrestha¹,

Beg²,

Imam³

et al. 2010

Reproduction

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Progesterone and luteal blood flow effects of an i.u. 2-h infusion of 0.25 mg/h of prostaglandin F 2a (PGF) that simulated a natural pulse of 13,14-dihydro-15-keto-PGF (PGFM) were compared to the effects of a single bolus i.u. injection of PGF (4 mg) that induced complete luteolysis in heifers. Blood sampling and an estimate of the percentage of luteal area with colour-Doppler signals of blood flow were performed every 2 min for 20 min and less frequently thereafter for 6 h. After the beginning of PGF infusion or a bolus injection, progesterone increased to a peak at 14 and 10 min respectively, and was accompanied by an increase in blood flow in the bolus group but not in the infusion group. Progesterone then decreased for 1 or 2 h and was accompanied by a continued elevation in blood flow in the PGF bolus group and by a slight increase in the PGF infusion group. Progesterone then rebounded in both groups, but the rebound was greater in the infusion group. Blood flow decreased during the descending arm of the progesterone rebound. Cortisol and prolactin began to increase 6 min after the bolus PGF injection but did not increase during or after PGF infusion. The increases in cortisol, prolactin and blood flow after a PGF bolus treatment but not during a simulated PGFM pulse indicated that the bolus treatment was pharmacologic, and its use may lead to faulty conclusions on the nature of physiologic luteolysis. The comparisons between progesterone and blood flow are novel.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Shrestha¹,

Beg²,

Imam³

et al. 2010

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“…Studies in cattle gave further evidence for a local transfer; instillation of unlabeUed PGF-2a into the uterine cavity resulted in a higher concentration of this prostaglandin in the ovarian artery than in the carotid artery (Hixon & Hansel, 1974).…”

Section: Introductionmentioning

confidence: 98%

Exchange of krypton-85 between the blood vessels of the human uterine adnexa

Bendz¹,

Einer‐Jensen²,

Lundgren³

et al. 1979

Reproduction

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Summary. A miniature Geiger\p=n-\M\l=u"\llerprobe was inserted into one ovary of 8 women undergoing hysterectomy. A control probe was inserted into the other ovary of 2 of the women. Krypton-85 in 0\m=.\15 m-NaCl was infused into the adjacent utero-ovarian vein and the radioactivity was registered for 5\p=n-\14min after the infusion. An increase of radioactivity was recorded in the ovary in 5 cases. In one of the women with 2 probes, no increase in radioactivity was observed in the control ovary. The results show a local transfer of gas from the ovarian branch of the uterine vein into the adjacent ovary, which may be due to a countercurrent exchange mechanism between the vessels of the human uterine adnexa.

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“…Este processo, denominado luteólise, determina a duração do ciclo estral e é caracterizado pelo cessar da produção de P4 e fragmentação dos componentes celulares, incluindo a redução do suporte vascular, proliferação do tecido conjuntivo, desorganização celular, degeneração e fagocitose das células luteais (MILVAE et al, 1996). A PGF2α é a substância responsável pela luteólise, sendo secretada pelo endométrio bovino num padrão pulsátil (SHEMESH & HANSEL, 1975) e atinge o CL por um sistema de transporte local veno-arterial de contracorrente (HIXON & HANSEL, 1974). O miométrio tem baixa capacidade de secretar PGF2α em resposta à OT e, portanto, não é considerado relevante na regulação luteolítica (ROBERTS et al, 1976).…”

Section: Luteóliseunclassified

Efeito do tratamento com progesterona e do diâmetro folicular nas características histológicas e moleculares uterinas em vacas Nelore em anestro pós-parto

Filho¹,

de²

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Evidence for Preferential Transfer of Prostaglandin F2α to the Ovarian Artery Following Intrauterine Administration in Cattle1

Cited by 82 publications

References 19 publications

Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2α in heifers

Exchange of krypton-85 between the blood vessels of the human uterine adnexa

Efeito do tratamento com progesterona e do diâmetro folicular nas características histológicas e moleculares uterinas em vacas Nelore em anestro pós-parto

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