Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes

Emamgholipour, Solaleh; Hossein–Nezhad, Arash; Sahraian, Mohammad Ali; Askarisadr, Fatemeh; Ansari, Mohammad

doi:10.1016/j.lfs.2015.12.014

Cited by 59 publications

(33 citation statements)

References 51 publications

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“…[74]. It was confirmed that melatonin also plays an important role in improving the antioxidant defense in MS through upregulation of sirtuin 1 (SIRT1) and its target genes for MnSOD and CAT [100]. Moreover, melatonin is selectively taken up by mitochondrial membranes, which makes it a potential therapeutic tool in treating neurodegenerative disorders [50].…”

Section: The Importance Of Antioxidants In Msmentioning

confidence: 99%

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

Adamczyk

Adamczyk-Sowa

2016

Oxidative Medicine and Cellular Longevity

115

100

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Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS) characterized by an inflammatory process and demyelination. The etiology of the disease is still not fully understood. Therefore, finding new etiological factors is of such crucial importance. It is suspected that the development of MS may be affected by oxidative stress (OS). In the acute phase OS initiates inflammatory processes and in the chronic phase it sustains neurodegeneration. Redox processes in MS are associated with mitochondrial dysfunction, dysregulation of axonal bioenergetics, iron accumulation in the brain, impaired oxidant/antioxidant balance, and OS memory. The present paper is a review of the current literature about the role of OS in MS and it focuses on all major aspects. The article explains the mechanisms of OS, reports unique biomarkers with regard to their clinical significance, and presents a poorly understood relationship between OS and neurodegeneration. It also provides novel methods of treatment, including the use of antioxidants and the role of antioxidants in neuroprotection. Furthermore, adding new drugs in the treatment of relapse may be useful. The article considers the significance of OS in the current treatment of MS patients.

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Section: The Importance Of Antioxidants In Msmentioning

confidence: 99%

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

Adamczyk

Adamczyk-Sowa

2016

Oxidative Medicine and Cellular Longevity

115

100

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“…Similarly, MLT promoted increased CAT concentration in the models of salivary gland injury and aggression to testicular tissue by ionizing radiation in multiple sclerosis [50][51][52].…”

Section: Catalasementioning

confidence: 99%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

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Abstract:Severe acute liver failure (ALF) manifests itself as a rare syndrome, with multiple etiologies for similar clinical conditions. Melatonin (MLT) is a lipophilic indolamine that is synthesized in the pineal gland from serotonin. This study was designed to evaluate hepatic changes resulting from the thioacetamide-induced ALF model, as well as the effects of MLT treatment in male Wistar rats (n = 56) in 24-and 48-h experiments. The results indicate a hepatoprotective effect of MLT, with no difference between the studied times, and increased animal survival.

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“…In MS, melatonin levels negatively correlate with disease activity, most likely via blockade of Th17 and induction of Tr1 differentiation via Nfil3 and Erk1/2, respectively 34 . Its therapeutic potential has been demonstrated in the animal model of MS (Experimental autoimmune encephalomyelitis, EAE) 34–36 and in in vitro studies using peripheral blood mononuclear cells (PBMCs) from MS patients and healthy controls, in which melatonin improves impaired antioxidant defense through upregulation of sirtuin 1 and antioxidant enzymes 37 . Given its antioxidant properties, which are relevant to neurodegeneration and demyelination 38 , melatonin might be an interesting therapeutic target for the treatment of both active and progressive stages of MS and thus worthy of further experimental and clinical study.…”

Section: Geographic Factors and Sun Exposurementioning

confidence: 99%

Environmental control of autoimmune inflammation in the central nervous system

Rothhammer

Quintana

2016

Current Opinion in Immunology

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Summary Multiple Sclerosis (MS) is a chronic autoimmune inflammatory demyelinating disorder of the central nervous system (CNS), which causes severe disability and requires extensive medical attention and treatment. While the infiltration of pathogenic immune cells into the CNS leads to the formation of inflammatory lesions in its initial relapsing-remitting stage, late stages of MS are characterized by progressive neuronal loss and demyelination even without continued interaction with the peripheral immune compartment. Several genetic and environmental factors modulate and influence these processes on multiple levels. Genetic variants confer a predisposition for the development of MS, but are not accessible to therapeutic intervention as of today. However, migration studies suggest that environmental factors influence disease development, activity and progression. This article reviews mechanisms of disease pathogenesis in MS and their modulation by environmental factors such as geographical localization, the gut microbiome and the diet.

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Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes

Cited by 59 publications

References 51 publications

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

Action of Melatonin on Severe Acute Liver Failure in Rats

Environmental control of autoimmune inflammation in the central nervous system

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