Evidence for polymicrobial communities in explanted vascular filters and atheroma debris

Ellis, Jeremy E.; Heuser, Richard R.; Missan, Dara S.; Martinez, Delyn; Heningburg, Avory M.; Shabilla, Matthew; Schwartz, Renata; Fry, Stephen E.

doi:10.1016/j.mcp.2017.04.001

Cited by 7 publications

(3 citation statements)

References 91 publications

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“…Mwaigwisya et al listed the molecular diagnostic tests for sepsis pathogens available on the market and proposed that NGS can be applied to rapidly and accurately diagnose BSIs [ 76 ]. Funneliformis mosseae was detected in coronary artery plaques from two deceased patients by an NGS-guided technique, and evidence of eukaryotes was found in 14 samples from a total of 15 patients [ 77 ]. After isolating fungal nucleic acids from the blood, etc., 24.8% of liver transplantation patients harbor relatively severe fungal infections.…”

Section: Ngs and Fungal Infection In Different Organsmentioning

confidence: 99%

Next-Generation Sequencing Applications for the Study of Fungal Pathogens

Jiang

Chen

et al. 2022

Microorganisms

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Next-generation sequencing (NGS) has become a widely used technology in biological research. NGS applications for clinical pathogen detection have become vital technologies. It is increasingly common to perform fast, accurate, and specific detection of clinical specimens using NGS. Pathogenic fungi with high virulence and drug resistance cause life-threatening clinical infections. NGS has had a significant biotechnological impact on detecting bacteria and viruses but is not equally applicable to fungi. There is a particularly urgent clinical need to use NGS to help identify fungi causing infections and prevent negative impacts. This review summarizes current research on NGS applications for fungi and offers a visual method of fungal detection. With the development of NGS and solutions for overcoming sequencing limitations, we suggest clinicians test specimens as soon as possible when encountering infections of unknown cause, suspected infections in vital organs, or rapidly progressive disease.

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Section: Ngs and Fungal Infection In Different Organsmentioning

confidence: 99%

Next-Generation Sequencing Applications for the Study of Fungal Pathogens

Jiang

Chen

et al. 2022

Microorganisms

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“…The prominent fungi in the sample Funneliformis mossea (formerly Glomus mosseae) is a common arbuscular mycorrhizal soil fungus, uncultivable, with worldwide distribution. It has been reported in humans by our laboratory [5][6][7]. The use of Doxycycline augments the fungal activity of terbinafine; doxycycline may play a role in reducing the fungal biofilm allowing the antifungal terbinafine to work more Austin J Clin Case Rep 8(9): id1229 (2021) -Page -02…”

Section: Discussionmentioning

confidence: 97%

Next Generation DNA Sequencing Diagnoses Fungal Etiology in Chronic Respiratory Disease, Clinical Response Supports Clinical Validity

Gordon¹,

SE²

2021

austinjclincaserep

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A 71-year white male presented to pulmonologists with progressively worsening respiratory problems with a chronic productive cough, asthma symptoms and malaise. The patient was subjected to the traditional treatment of antibiotics, cough suppressants, and inhaled bronchodilator and corticosteroids. After multiple failed combinations of antibiotics, cough suppressants, and inhalers, the patient had a sputum sample, which was analyzed by special stains and targeted Next Generation DNA Sequencing (NGS). Fungal eukaryotic (18S) NGS identified by ‘best match’, Candidae parapsilosis and C. viswanathii and an organism in the Glomerulaceae family, Funnelformis mosseae. The patient was prescribed an antifungal in tandem with an antibiotic, Terbinafine and Doxycycline. The patient rapidly improved to his baseline. This communication communicates the potential of NGS microbial sequencing in pathogen identification in chronic pulmonary disease and improved clinical outcome.

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“…Besides bacteria and viruses, some protozoa and fungi have also been isolated from atherosclerotic plaques, which brings their impact up for discussion [25].…”

Section: Virusesmentioning

confidence: 99%

The Role of Microbiologic Agents in the Progression of the Atherosclerosis: A comprehensive review

Karabulut¹

2020

Journal of the Saudi Heart Association

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Atherosclerosis is a leading cause of disability, morbidity and mortality in the world. Atherosclerosis is accepted as a chronic progressive inflammatory disease. The inflammatory cascade in the vascular wall is well-defined. However, the predictors and contributors of the inflammatory response in atherosclerosis are not completely understood. Systemic and local inflammation, which enhance the burden of inflammation in the vascular wall, have been proposed as risk factors for the progression of atherosclerosis. Infectious microorganisms are one of the major triggering factors for local and systemic inflammation. In this review, we aimed to emphasize the linkage between microorganisms and the progression of atherosclerosis. We briefly summarize the current medical literature and discuss the future perspectives of the linkage between microbial agents and atherosclerosis representing cause and effect.

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Evidence for polymicrobial communities in explanted vascular filters and atheroma debris

Cited by 7 publications

References 91 publications

Next-Generation Sequencing Applications for the Study of Fungal Pathogens

Next-Generation Sequencing Applications for the Study of Fungal Pathogens

Next Generation DNA Sequencing Diagnoses Fungal Etiology in Chronic Respiratory Disease, Clinical Response Supports Clinical Validity

The Role of Microbiologic Agents in the Progression of the Atherosclerosis: A comprehensive review

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