Evidence for NMDA receptor in the afferent synaptic transmission of the vestibular system

Soto, Enrique; Flores, Amira; Eróstegui, Carlos; Vega, Rosario

doi:10.1016/0006-8993(94)91551-2

Cited by 43 publications

(15 citation statements)

References 26 publications

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“…1 ). Glutamate released at hair cell afferent synapses interacts with several subtypes of excitatory amino acid (EAA) receptor, including N-methyl-D-aspartic acid (NMDA), α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA), kainic acid (KA) receptors, and metabotropic receptors [7, 38, 52, 73, 116, 137, 139]. The NMDA receptors participate in determining the basal discharge and tonic response to sustained stimuli, whereas non-NMDA receptors seem to mediate responses to high-frequency mechanical stimulation [39, 139].…”

Section: Drugs With Effects On Neurotransmitters and Neuromodulator Rmentioning

confidence: 99%

Neuropharmacology of Vestibular System Disorders

Soto¹,

Vega²

2010

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This work reviews the neuropharmacology of the vestibular system, with an emphasis on the mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists are confronted with a rapidly changing field in which advances in the knowledge of ionic channel function and synaptic transmission mechanisms have led to the development of new scientific models for the understanding of vestibular dysfunction and its management. In particular, there have been recent advances in our knowledge of the fundamental mechanisms of vestibular system function and drug mechanisms of action. In this work, drugs acting on vestibular system have been grouped into two main categories according to their primary mechanisms of action: those with effects on neurotransmitters and neuromodulator receptors and those that act on voltage-gated ion channels. Particular attention is given in this review to drugs that may provide additional insight into the pathophysiology of vestibular diseases. A critical review of the pharmacology and highlights of the major advances are discussed in each case.

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Section: Drugs With Effects On Neurotransmitters and Neuromodulator Rmentioning

confidence: 99%

Neuropharmacology of Vestibular System Disorders

Soto¹,

Vega²

2010

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“…At the hair cell/vestibulocochlear nerve synapse, glutamate is the afferent neurotransmitter (Klinke and Oertel 1977;Felix and Ehrenberger 1990;Ehrenberger and Felix 1991; for a review, see Eybalin 1993). Individual glutamate receptors of the AMPA/kainate receptor subtype (for a review, see Nakanishi 1992) as well as the NMDA receptor subtype (Monyer et al 1992;Hollmann et al 1993;Ishii et al 1993) are expressed in the adult cochlea (Ryan et al 1991;Doi et al 1992;Kuriyama et al 1993Kuriyama et al , 1994Soto et al 1994;Wenthold et al 1994;Luo et al 1995;Niedzielski and Wenthold 1995;Usami et al 1995; for a review, see Eybalin 1993). In addition to NMDA receptor antibodies, we employed polyclonal antibodies to GluR1, GluR2/3 and GluR4 (Chemicon).…”

Section: Introductionmentioning

confidence: 97%

Transient expression of NMDA receptors during rearrangement of AMPA-receptor-expressing fibers in the developing inner ear

Knipper

Köpschall

Rohbock

et al. 1996

Cell and Tissue Research

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A major reorganization of afferent and efferent nerve terminals, concomitant to significant neuronal cell loss and pruning of superfluous fibers, takes place during the development of the organ of Corti, prior to the onset of hearing. We examined the spatio/temporal distribution of subtype-specific AMPA- and N-methyl-d-aspartate (NMDA)-selective glutamate receptor proteins in postnatal inner ears from rats during this critical period. From the first postnatal day onwards, GluR2/3 receptor subtypes appeared in nerve endings of afferent fibers associated with inner and outer hair cells. During the following 2 weeks, GluR2/3 receptors were downregulated in exchange for GluR4 receptors. In parallel efferents projecting from the medial olivocochlear complex to the outer hair cells underwent synaptogenesis and efferents projecting from the lateral olivocochlear complex to the inner hair cells appeared to change contacts to the dendrites of afferents. Concomitant to these events, NMDA receptor subtypes NR1 and NR2A transiently appeared in hair cells as well as afferent and efferent fibers. Recently, we described a temporary expression of the neurotrophin receptor trkB in hair cells, coincident to the growth (GAP-43) and synaptogenesis (synaptophysin) of efferents. Here, we show that trkB was expressed together with NR1 receptors in hair cells in high spatio/temporal correlation with the rearrangement of afferents and efferents. Cochlea NMDA receptors may, therefore, be a part of the mechanism by which, in addition to neurotrophic activity, the mature phenotype of cochlea neurons is acquired through activity-dependent processes.

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“…This kind of stimulation could allow not only the activation 'in situ' of the semicircular canals but also substitute for other procedures of mechanical stimulation requiring more complex (by producing fluid flows inside the canal; Valli and Zucca, 1977;Valli et al, 1990) or expensive (by using turn-tables; Dickman and Correia, 1989;Rossi et al, 1994;Soto et al, 1994) machinery.…”

Section: Introductionmentioning

confidence: 99%

Caloric stimulation of ampullar receptors: a new method to produce mechanically-evoked responses in frog semicircular canals

Zucca

Botta

Valli

et al. 1999

Journal of Neuroscience Methods

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A microthermistor positioned close to the exposed posterior semicircular canal in isolated labyrinth preparations of the frog was used to stimulate the sensory organ. Our results indicated that, depending on the position of the heater, the induced endolymphatic convection currents may result in either excitatory or inhibitory cupular deflections and thus in a modulation of ampullar receptor resting activity. Other possible thermal-dependent mechanisms, such as a direct action of the stimulus on vestibular sensors or endolymphatic volume changes, had, in the present experimental conditions, a minor role. Caloric stimulation could therefore represent a novel method to stimulate the semicircular canals 'in situ'.

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Evidence for NMDA receptor in the afferent synaptic transmission of the vestibular system

Cited by 43 publications

References 26 publications

Neuropharmacology of Vestibular System Disorders

Neuropharmacology of Vestibular System Disorders

Transient expression of NMDA receptors during rearrangement of AMPA-receptor-expressing fibers in the developing inner ear

Caloric stimulation of ampullar receptors: a new method to produce mechanically-evoked responses in frog semicircular canals

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