Evidence for muscle fiber hyperplasia in the septum of patients with hypertrophic obstructive cardiomyopathy (HOCM). Quantitative examination of endomyocardial biopsies (EMCB) and myectomy specimens

Frenzel, H; Schwartzkopff, B.; Reinecke, Petra; Kamino, Kazuo; Lösse, B

doi:10.1007/978-3-642-85369-2_3

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Cats with TMT were younger (2 [0.4-11.4] years) than cats with HCM (8 [1. [6][7][8][9][10][11][12][13][14] years), P < 0.0001. Males were over-represented in the HCM group (18 of 21 cats were male versus 10 of 21 males in the TMT group, P = 0.02).…”

Section: Resultsmentioning

confidence: 99%

“…A total of 174 echocardiographic scans were evaluated from the 42 cats enrolled in the study. Cats with TMT had a median of 3 [2][3][4][5][6][7] scans and cats with HCM 4 [2][3][4][5][6][7][8][9] scans performed during the study period. The time elapsed between the first and last echo was 8 [1.0-57] months for the whole population and 6 months for cats with TMT and 10 months for cats with HCM.…”

Section: Echocardiographic Datamentioning

confidence: 99%

“…Myocardial wall thickness depends on 3 elements: the number of myocytes, myocyte size, and the volume of the interstitial space . In HCM, the increased LVWT is mediated by an increase in mass of individual myocytes and interstitial fibrous connective tissue, with the former being the most important component . Other diseases can mimic HCM by causing an increase in LVWT that is not due to myocyte hypertrophy or hyperplasia, such as intracellular accumulation of metabolic products (storage diseases) or interstitial infiltration of proteins, cells or fluid, such as in amyloidosis or myocarditis .…”

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confidence: 99%

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Transient Myocardial Thickening in Cats Associated with Heart Failure

Matos

Pereira

Glaus

et al. 2017

Veterinary Internal Medicne

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BackgroundCats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can have resolution of both left ventricular hypertrophy and CHF.ObjectivesTo describe the clinical characteristics of cats with transient myocardial thickening (TMT) and CHF compared with a control population of cats without resolution of HCM.AnimalsA total of 21 cats with TMT, 21 cats with HCM.MethodsRetrospective study. Clinical records at 4 veterinary centers were searched for TMT cases and a control group of cats with HCM and CHF. TMT was defined as initial maximal left ventricular wall thickness (LVWT) ≥6 mm with left‐sided CHF, with subsequent resolution of CHF, reduction in left atrium/aorta (LA/Ao), and LVWT<5.5 mm. HCM was defined as persistent LVWT ≥6 mm.ResultsCats with TMT were younger (2 [0.4–11.4] years) than cats with HCM (8 [1.6–14] years) (P < 0.0001), and antecedent events were more common (15/21 versus 6/21, respectively) (P = 0.01). In cats with TMT, LVWT normalized from 6.8 [6.0–9.7] mm to 4.8 [2.8–5.3] mm and LA/Ao decreased from 1.8 [1.6–2.3] to 1.45 [1.2–1.7] after a mean interval of 3.3 (95% CI: 1.8–4.7) months. CHF recurred in 1 of 21 TMT and 15 of 21 cats with HCM. Cardiac treatment was discontinued in 20 of 21 cats with TMT and 0 of 21 HCM cats. All cats with TMT survived, whereas 8 of 19 cats with HCM died during the study period.Conclusions and Clinical ImportanceTMT occurs in younger cats, and antecedent events are common. The prognosis is better in cats with CHF associated with TMT than HCM.

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Section: Resultsmentioning

confidence: 99%

Section: Echocardiographic Datamentioning

confidence: 99%

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Transient Myocardial Thickening in Cats Associated with Heart Failure

Matos

Pereira

Glaus

et al. 2017

Veterinary Internal Medicne

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“…TSM will locally increase left ventricular compliance by reducing LV wall thickness and widening the LV outflow tract at the site of myectomy. At rest, hypertrophy of the ventricle, mainly determined by myocytic hyperplasia and hypertrophy [16], plays a crucial role in the magnitude of filling pressures in hypertrophic cardiomyopathy. However, pulmonary capillary wedge pressures under symptom limited exercise was significantly related to collagen type I volume fraction and cross-linking in the myectomy specimens after surgery, providing evidence that the collagen structure might be a decisive parameter in impaired compliance after TSM.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Collagen Type I and Impaired Left Ventricular Function under Exercise in Hypertrophic Cardiomyopathy

Mundhenke¹,

Schwartzkopff²,

Stark³

et al. 2002

Thorac cardiovasc Surg

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Increased cardiac mRNA expression of matrix metalloproteinase-1 (MMP–1) and its inhibitor (TIMP–1) in DCM patients

et al. 2006

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Left ventricular dilation and myocardial remodeling are hallmarks of dilated cardiomyopathy (DCM). It is assumed that left ventricular dilation is caused by the disintegration of the collagenous network by increased collagenolytic activity of matrix metalloproteinases (MMPs) and their adequate tissue inhibitors (TIMPs). In this study the myocardial MMP-1 and TIMP-1 mRNA expressions were investigated by using real-time quantitative PCR analysis from right septal endomyocardial biopsies of patients with dilated cardiomyopathy (n = 46) and control subjects (n = 11). The volume density (Vv%) of collagen was measured morphometrically. Classification was done according to LV diameters [left ventricular enddiastolic diameter (LVEDD, cm) calculated to body surface area (BSA, m(2))] into three DCM groups: group I (LVEDD-BSA > 2.7-3.0 cm/m(2)), group II ( > 3.0-3.6 cm/m(2)), group III ( > 3.6 cm/m(2)), controls (< 2.7 cm/m(2)). Compared with controls, the MMP-1 expression in patients with DCM was significantly increased (119.2 +/- 45.2 vs. 1.3 +/- 0.4; p < 0.001) as was TIMP-1 expression (9.6 +/- 1.2 vs. 1.3 +/- 0.4; p < 0.01). Moreover the MMP-1 and TIMP-1 expression varied according to LV diameter: group I (MMP-1: 8.7 +/- 3.5; p = 0.33; TIMP- 1: 4.5 +/- 1.2; p < 0.01); group II (MMP-1: 211.4 +/- 86.0; p < 0.001; TIMP-1: 12.5 +/- 1.9 ; p < 0.001); group III (MMP-1: 38.8 +/- 22.6; p < 0.01; TIMP-1: 8.1 +/- 1.7; p < 0.001). Compared with controls, the collagen level in DCMPt. was significantly increased: 5.0 +/- 0.6 vol% vs 1.2 +/- 0.2 vol% p < 0.001 and correlates with LV diameter. This study reveals that the overexpression of MMP-1, which is associated with an increased ratio of MMP-1/TIMP-1 in DCM, indicates an activated collagenolytic system while replacement fibrosis is accumulating. The MMP-1 overexpression is mainly found in moderately dilated DCM hearts (group II) indicating the dynamic process of LV dilation and the importance of collagenases in the early phase of LV remodeling.

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Evidence for muscle fiber hyperplasia in the septum of patients with hypertrophic obstructive cardiomyopathy (HOCM). Quantitative examination of endomyocardial biopsies (EMCB) and myectomy specimens

Cited by 5 publications

References 15 publications

Transient Myocardial Thickening in Cats Associated with Heart Failure

Transient Myocardial Thickening in Cats Associated with Heart Failure

Myocardial Collagen Type I and Impaired Left Ventricular Function under Exercise in Hypertrophic Cardiomyopathy

Increased cardiac mRNA expression of matrix metalloproteinase-1 (MMP–1) and its inhibitor (TIMP–1) in DCM patients

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