Evidence for microsatellite instability in bilateral breast carcinomas

Imyanitov, Evgeny N.; Togo, A.; Suspitsin, Evgeny N.; Grigoriev, M.; Pozharisski, Kazimr M; Turkevich, E A; Hanson, Kaido P.; Hayward, Nicholas K.; Chenevix-Trench, Georgia; Theillet, Charles; Lavin, Martin F.

doi:10.1016/s0304-3835(99)00444-9

Cited by 21 publications

(14 citation statements)

References 22 publications

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“…Bucholz and Wu found that women with bilateral breast cancer showed significantly higher levels of radiation-induced chromatid breaks than did healthy controls (19). Imyanitov and colleagues reported microsatellite instability in 15% of 46 bilateral breast cancers from 23 women (20).…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Bilateral Breast Cancers in BRCA Carriers

Weitzel

Robson

Pasini

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Women with breast cancer and a BRCA mutation have a high risk of developing a contralateral breast cancer. It is generally believed that the two cancers represent independent events. However, the extent of concordance between the first and second tumors with respect to hormone receptor expression and other pathologic features is unknown. Purpose: To determine the degree of concordance of estrogen receptor (ER) status, tumor grade, and histology in tumors from women with bilateral breast cancer and a BRCA mutation. Subjects and Methods: Women with a history of bilateral invasive breast cancers were selected from an international registry of women with BRCA1 or BRCA2 mutations. Medical records were reviewed to document the characteristics of each cancer and the treatments received.

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Section: Discussionmentioning

confidence: 99%

A Comparison of Bilateral Breast Cancers in BRCA Carriers

Weitzel

Robson

Pasini

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Surprisingly, we observed several tumors with the "colonic" type MSI, which is very uncommon for cancers of the breast (Adem et al 2003;Anbazhagan et al 1999;Halford et al 2003;Seitz et al 2003;Siah et al 2000;Zhou et al 1998). Here we present an update of our earlier investigation, which contains the following improvements: (1) contrary to the report (Imyanitov et al 2000), the analysis of MSI was the primary goal of this study; therefore, MSI-speciWc markers were used instead of the ones designed for the analysis of losses of heterozygosity; (2) the collection of biBC tumors was signiWcantly enlarged; (3) the control group of unilateral breast carcinomas (BC) was examined as well. We conWrm that MSI-H does occur in bilateral but not in unilateral breast cancers.…”

Section: Introductionmentioning

confidence: 99%

“…In our earlier report we described microsatellite analysis of allelic imbalances in bilateral breast carcinomas (biBC) (Imyanitov et al 2000). Surprisingly, we observed several tumors with the "colonic" type MSI, which is very uncommon for cancers of the breast (Adem et al 2003;Anbazhagan et al 1999;Halford et al 2003;Seitz et al 2003;Siah et al 2000;Zhou et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Microsatellite instability analysis of bilateral breast tumors suggests treatment-related origin of some contralateral malignancies

Kuligina

Grigoriev

Suspitsin

et al. 2006

J Cancer Res Clin Oncol

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“…In primary breast carcinoma, LOH represents the most frequent mutation (van de Vijver, 1993) and affects a large number of distinct chromosomal regions (Devilee and Cornelisse, 1994;Bieche and Lidereau, 1995;Kerangueven et al, 1997;Ingvarsson, 1999), notably 1p (Nagai et al, 1995;Tsukamoto et al, 1998;Imyanitov et al, 2000;Lerebours et al, 2002;Wang et al, 2004) and 10q (Richard et al, 2000;Jones et al, 2001;Kleivi et al, 2002;Achary et al, 2003;Wang et al, 2004). These two human chromosomal segments are also the site of frequent deletions (LOH) in several other tumor types (Saran et al, 1996;Schwab et al, 1996;Knuutila et al, 1999;Yeh et al, 1999;Dong, 2001;Qin, 2002;Inda et al, 2003;Thiessen et al, 2003;Karoui et al, 2004;Zhu et al, 2004).…”

Section: Introductionmentioning

confidence: 95%

“…In an effort to identify novel putative TSGs that may reside in the LOH regions previously identified, we focused our efforts on two LOH regions, Naad4 and Naad7 on chromosome 4 and 19, respectively, previously found in a high proportion of these Erbb2-induced Tg mammary tumors. These regions are homologous to human 1p32-36 and 10q23-26, respectively, which are known to be the sites of frequent LOH in human breast tumors (Nagai et al, 1995;Tsukamoto et al, 1998;Imyanitov et al, 2000;Richard et al, 2000;Jones et al, 2001;Kleivi et al, 2002;Lerebours et al, 2002;Achary et al, 2003;Wang et al, 2004). Because TSG identification is facilitated by narrowing the LOH region of interest to a shorter interval in as many informative tumors as possible, higher-resolution allelotyping was performed.…”

Section: Introductionmentioning

confidence: 99%

Fine allelotyping of Erbb2‐induced mammary tumors in mice reveals multiple discontinuous candidate regions of tumor‐suppressor loci

Cool

Depault

Jolicoeur

2005

Genes Chromosomes & Cancer

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Loss of heterozygosity (LOH) at human chromosome bands 1p32-36 and 10q23-26 is frequent in various human tumors, including breast cancers, and is thought to reflect the loss of tumor-suppressor genes (TSGs). To map such genes, high-resolution LOH analysis was performed on 93 Erbb2-induced mammary tumors from (BALB/c x C57BL/6) F1 MMTV/Erbb2 transgenic mice. A panel of 24 microsatellite markers specific to the region of mouse chr4, homologous to human 1p31-36, and 16 markers specific to the mouse chr19 region, homologous to human 10q23-26 were used. In addition, lower-density mapping was performed on the remaining portion of mouse chr4 [homologous to human 9p13, 9p21-24, 9q21-22, 9q31-34 (12 markers)] and chr19 [homologous to 9q21, 9p24, 11q12-13 (9 markers)]. Several distinct, discrete, and discontinuous LOH regions flanked by areas of heterozygosity were identified, 22 on chr4 and 14 on chr19. Among these, 13 were mapped in the region of homology with human 1p31-36 (between D4Mit153 and D4Mit254) and 9 in the region of homology with human 10q23-26 (between D19Mit46 and D19Mit6). Although several LOH loci span a large interval, many are relatively short (1-4 Mb), and a few span an interval of <1 Mb. This allelotyping represents the highest density of LOH loci yet mapped in these chromosomal regions. The presence of numerous LOH regions in alternation with regions of heterozygosity, consistent with mitotic recombination as a mechanism for generating such a mosaic pattern, suggests the presence of several TSGs in these regions and should facilitate their identification.

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Evidence for microsatellite instability in bilateral breast carcinomas

Cited by 21 publications

References 22 publications

A Comparison of Bilateral Breast Cancers in BRCA Carriers

A Comparison of Bilateral Breast Cancers in BRCA Carriers

Microsatellite instability analysis of bilateral breast tumors suggests treatment-related origin of some contralateral malignancies

Fine allelotyping of Erbb2‐induced mammary tumors in mice reveals multiple discontinuous candidate regions of tumor‐suppressor loci

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