Evidence for mesangial glomerular receptors for angiotensin II linked to mesangial cell contractility

Foidart, Jacqueline; Sraer, J D; Delarue, F; Mahieu, P.; Ardaillou, Raymond

doi:10.1016/0014-5793(80)80375-9

Cited by 106 publications

(36 citation statements)

References 16 publications

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“…Each cell was compared before and after the hormone addition for the changes in both cell contour and cytoplasmic density, morphological changes thought to represent contraction ( Fig. 1 b) (1,2,6 …”

Section: Methodsmentioning

confidence: 99%

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Ambient C1- ions modify rat mesangial cell contraction by modulating cell inositol trisphosphate and Ca2+ via enhanced prostaglandin E2.

Okuda

Kojima²,

Ogata³

et al. 1989

J. Clin. Invest.

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Our recent observation showed that angiotensin II (All) and arginine vasopressin (AVP) stimulate Ca2 -activated Cl-conductance in mesangial cells. These data raise the possibility that mesangial cell function may be modulated by extracellular chloride concentration [Cl]0 decreased and the effects of ambient Cl-deprivation could be restored by addition of indomethacin to the Cl--free medium. Moreover, PGE2 decreased mesangial cell contractility, Ca2+ transients, and IP3 production in response to All and AVP. These data suggest that the decrease in [CI-]0 attenuates mesangial cell contraction by suppressing IP3 production and thus Ca2+ transients in response to All and AVP through enhanced PGE2 production.

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Section: Methodsmentioning

confidence: 99%

“…Angiotensin II (All)' and arginine vasopressin (AVP) evoke contraction (1)(2)(3)(4)(5)(6) and stimulate PG synthesis (3,(7)(8)(9) of mesangial cells. Inositol trisphosphate (IP3) production and Ca2+ transients are thought to play an important role in mediating the hormonal effects in mesangial cells (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Ambient C1- ions modify rat mesangial cell contraction by modulating cell inositol trisphosphate and Ca2+ via enhanced prostaglandin E2.

Okuda

Kojima²,

Ogata³

et al. 1989

J. Clin. Invest.

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“…Experiments were performed on days 14-16 of the first subculture, before the cells reached confluence and at a time when the passaged cells have hormone receptors (19 Contraction experiments. Several hours before these experiments, the culture medium was changed to Ca++-and Mg++-free Hanks' balanced salt solution supplemented with 10% fetal bovine serum to facilitate relaxation of the mesangial cells, which remained adherent to the dish (1).…”

Section: Methodsmentioning

confidence: 99%

Prostaglandin synthesis by rat glomerular mesangial cells in culture. Effects of angiotensin II and arginine vasopressin.

Scharschmidt¹,

Dünn²

1983

J. Clin. Invest.

215

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A B S T R A C T Arginine vasopressin (AVP) and angiotensin II (ANG II) reduce the glomerular filtration rate and ultrafiltration coefficient. Vasodilatory prostaglandins (PG) antagonize these effects. AVP and ANG II also cause mesangial cell contraction. Therefore, possible PG stimulation by these peptides and two vasopressin analogues was studied in cultured rat glomerular mesangial cells. The effect of altered calcium availability on PG production was also studied.Glomeruli from 75-100-g Sprague-Dawley rats were cultured in supplemented nutrient media for 28 d and experiments were performed on the first passage. Mesangial cell morphology was confirmed by electron microscopy. Cells produced PGE2 > PGF2a > 6-ketoPGFia > thromboxane B2 when incubated with the divalent cation ionophore, A23187, or arachidonic acid (C20:4). ANG II and AVP selectively stimulated PGE2 at threshold concentrations of 10 nM ANG II and 100 pM of AVP. The effects of the antidiuretic analogue 1-desamino-8-D-arginine vasopressin (dDAVP) and the antipressor analogue [1-(,-

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“…Several studies demonstrated that mesangial cells possess specific receptors for a number of vasoactive substances that couple to phospholipase C. Receptors for angiotensin I1 [45,72], vasopressin [27,73], PDGF [74] and LTD4 [75] have been identified on mesangial cells. Binding of these agents to their specific receptors is associated with activation of a phospholipase C that specifically cleaves PIP2 to yield DAG and IP3.…”

Section: Phospholipase C: the Bifurcating Inositol Lipid Signalling Smentioning

confidence: 99%

Cross‐talk between transmembrane signalling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells

Pfeilschifter

1989

Eur J Clin Investigation

105

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Evidence for mesangial glomerular receptors for angiotensin II linked to mesangial cell contractility

Cited by 106 publications

References 16 publications

Ambient C1- ions modify rat mesangial cell contraction by modulating cell inositol trisphosphate and Ca2+ via enhanced prostaglandin E2.

Ambient C1- ions modify rat mesangial cell contraction by modulating cell inositol trisphosphate and Ca2+ via enhanced prostaglandin E2.

Prostaglandin synthesis by rat glomerular mesangial cells in culture. Effects of angiotensin II and arginine vasopressin.

Cross‐talk between transmembrane signalling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells

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