Evidence for Mendelian Inheritance in the Pathogenesis of Lung Cancer

Sellers, Thomas A.; Bailey-Wilson, Joan E.; Elston, Robert C.; Wilson, Alexander F.; Elston, Gillian Z.; Ooi, Wee Lock; Rothschild, Henry

doi:10.1093/jnci/82.15.1272

Cited by 233 publications

(113 citation statements)

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“…The existence of genetic susceptibility to lung cancer is suggested in a number of familial aggregation studies [4][5][6]8,[15][16][17][18][19] as well as in segregation analyses [20][21][22][23][24] and in a linkage study 25 Familial risks may reflect not only genetic predisposition, but also shared exposures, such as smoking habits, [27][28][29] or exposure to cooking fumes. 7,30 To address this issue, we (i) included only relatives of never-smoking probands; (ii) took into account smoking habits of the relatives, both by controlling for smoking status and by conducting analyses stratified by smoking status.…”

Section: Discussionmentioning

confidence: 99%

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Gorlova

Weng

Zhang

et al. 2007

Intl Journal of Cancer

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The authors evaluated the familial aggregation of lung and other cancers in first-degree relatives of lung cancer patients selfreported to be lifetime never smokers. The data, derived from a large lung cancer case-control study, included 2,465 first-degree relatives of 316 never smoker lung cancer cases and 2,441 firstdegree relatives of 318 never smoker controls, frequency matched to the cases on age, gender and ethnicity. The median age of the cases and the controls was 61 years, about 2/3 were women, and about 80% were Caucasian. Overall, there was a 25% excess risk [95% CI (1.05-1.50)] of any type of cancer among the first-degree relatives of cases, and case offspring exhibited a 2-fold excess cancer risk (1.03-4.10) compared with control offspring. There was also a 44% excess risk ( Key words: lung cancer; familial aggregation; never smokers Lifetime never smokers with lung cancer likely represent a genetically susceptible subgroup distinct from ever smokers with lung cancer. 1 Familial aggregation may provide indirect evidence for a role of genetic factors in lung cancer susceptibility. The majority of studies that have evaluated familial aggregation in never-smoking lung cancer patients reported increased but not statistically significant lung cancer risk. [2][3][4][5][6][7][8][9] Several recent studies that analyzed aggregation of lung cancer in relatives of lung cancer patients reported no increased risk in first-degree relatives of never-smoking lung cancer cases. 8,9 However, one study suggested a significant 6-fold increased lung cancer risk in relatives of younger (40-59 years old) nonsmoking lung cancer patients, yet based on a small number of individuals (47 lung cancer cases and 50 controls). 3 Only a few studies have evaluated occurrence of other specific cancers in relatives of never-smoking lung cancer patients. 7,10,11 We estimated the risk of lung cancer and other cancers in firstdegree relatives of never-smoking lung cancer cases compared with first-degree relatives of matched controls, using self-reported data on family history derived from an ongoing lung cancer casecontrol study, controlling for relatives' smoking status as reported by the proband. Material and methods Subject recruitmentFrom September 1995 through December 2003, patients with lung cancer were accrued for an ongoing and previously described molecular epidemiological study on susceptibility markers for lung cancer from The University of Texas M. D. Anderson Cancer Center. 8,12,13 There were no age, gender, ethnic or stage restrictions. There were 316 patients with histologically confirmed lung cancer, who reported themselves to be lifetime never smokers (defined as those who had smoked less than 100 cigarettes in their lifetime). The response rate for cases was about 80%. The reasons for refusal to participate included patient too ill, patient referred only for second opinion to M. D. Anderson Cancer Center or patient unwilling to donate blood for the study and complete the interview. Healthy controls who were also lifeti...

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Section: Discussionmentioning

confidence: 99%

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Gorlova

Weng

Zhang

et al. 2007

Intl Journal of Cancer

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“…Existem evidências de que a hereditariedade tenha um peso nesse processo. Não há conhecimento preciso sobre marcadores genéticos envolvidos com o câncer do pulmão, mas estudos recentes o têm relacionado a uma alteração do citocromo 450 e do cromossomo 22 (54) .…”

Section: Ix) Fatores Genéticosunclassified

Epidemiologia do câncer do pulmão

Zamboni¹

2002

J. Pneumologia

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O câncer do pulmão, de doença rara no início do século XX, tornou-se a neoplasia mais letal em todo o mundo. Essa mudança se iniciou na segunda década do século, quando se observou que o número de casos vinha aumentando em todo o mundo. Somente na década de 1950 INTRODUÇÃODe doença rara no passado, o câncer do pulmão transformou-se na doença neoplásica mais comum e mais mortal, em todo o mundo. É, hoje em dia, a principal causa de morte por câncer entre os homens da América do Norte e da Europa; sua mortalidade vem aumentando, significativamente, entre as populações da Ásia, da Amé-

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“…Furthermore, Tokuhata and Lilienfeld ( 19) reported that lung cancer among relatives of patients with lung cancer are 2.7 times greater than that amongrelatives of controls. Segregation analysis further suggests that Mendelian inheritance of a rare major autosomal gene mayproduce lung cancer at an earlier age of onset (20 mainly participated in familial occurrence of lung cancer, since i) smoking indexes were not very high in these patients, ii) ovarian cancer was present in one patient, and iii) the onset of lung cancer wasobserved in relatively younger ages. The coexistence of idiopathic pulmonary fibrosis (IPF) and carcinoma of the lung, especially BAC, is well known (9).…”

Section: Discussionmentioning

confidence: 97%

Occurrence of Bronchioloalveolar Cell Carcinoma in Two Brothers: Comparison of Clinical Features and Immunohistochemical Findings.

Nanki

Fujita

Ohtsuki³

et al. 2002

Intern. Med.

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It has been suggested that lung cancer sometimes aggregates in families. However, the familial occurrence of bronchioloalveolar carcinoma (BAC) is extremely rare. We present a family in which two brothers had BAC. The clinical features and immunohistochemical findings of BACin the two brothers were compared.Immunohistochemical findings revealed that both cases of BAChad very similar immunopathological features in epithelial marker expression. A review of the literature revealed that this is the third case of BACsin a single family.

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Evidence for Mendelian Inheritance in the Pathogenesis of Lung Cancer

Cited by 233 publications

References 0 publications

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Aggregation of cancer among relatives of never‐smoking lung cancer patients

Epidemiologia do câncer do pulmão

Occurrence of Bronchioloalveolar Cell Carcinoma in Two Brothers: Comparison of Clinical Features and Immunohistochemical Findings.

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