Evidence for mast cell activation in collagenous colitis

Non-invasive investigation of inflammatory bowel disease

“…Some, such as mast cells and eosinophils, are thought to play a central role in mediating intestinal allergic reactions [69] . However, both types of cell are found to be activated in a number of other gastrointestinal inflammatory diseases such as inflammatory bowel disease, coeliac disease, eosinophilic gastroenteritis [69] and collagenous colitis [70] , suggesting that both cell types may be involved in the pathogenesis of chronic intestinal inflammation. It may therefore be possible, as for neutrophils and calprotectin, to identify mast cell granule proteins, such as tryptase and chymase, in faecal samples and use them as markers of a specific component of the intestinal inflammatory response.…”

Biopsy interpretation of colonic biopsies when inflammatory bowel disease is excluded

“…Increased colonic mucosal mast cells may also be seen in ulcerative colitis [117], CC [118], gluten-sensitive enteropathy [119], radiation colitis [120], eosinophilic colitis [109], and all forms of irritable bowel syndrome [116]. Mast cell diseases that involve the gut include systemic mastocytosis and cutaneous mastocytosis with gastrointestinal symptoms.…”

Cloning and expression of human colon mast cell carboxypeptidase

“…Mast cells and their inflammatory mediators have been implicated to play a pivotal role in intestinal diseases such as inflammatory bowel disease [1][2][3][4][5][6][7] , collagenous colitis [8,9] , intestinal anaphylaxis [10,11] and irritable bowel syndrome [11,12] . Mast cell neutral proteases constitute more than 50% granule proteins in mast cells.…”