Evidence for mannose-mediated adherence of Candida albicans to human buccal cells in vitro

Sandin, Ramón L.; Rogers, Alvin L.; Patterson, Ronald J.; Beneke, E. S.

doi:10.1128/iai.35.1.79-85.1982

Cited by 158 publications

(68 citation statements)

References 25 publications

(31 reference statements)

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“…The level of adhesion of C. albicans to the buccal cells was assessed by the method of Sandin et al (26). Briefly, 0.2 ml of a mixed suspension of buccal cells (10 5 /ml) and yeast cells (10 7 /ml) was incubated with shaking at 180 r.p.m.…”

Section: Candidal Adhesionmentioning

confidence: 99%

Influence of aging on candidal growth and adhesion regulatory agents in saliva

Tanida

Ueta

Tobiume

et al. 2001

J Oral Pathology Medicine

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Although oral candidiasis is frequently seen in the elderly, the factors determining candidal growth have insufficiently been explored. Hence, we examined the influence of aging on candidal adhesion and growth-inhibitory agents in saliva in 45 healthy volunteers and 60 patients with oral candidiasis. Both non-stimulated and stimulated salivary flow rates (SFRs) in the healthy controls decreased with aging. A gradual decrease of SFRs with aging was also observed in the patients, and the SFR levels were markedly lower than those in the controls. Although the salivary glucose levels were almost constant in all age groups, secretory immunoglobulin A and lactoferrin levels in saliva were significantly decreased statistically with age, and a marginal age-associated decrease in transferrin levels was also observed. In addition, the generation of superoxide from neutrophils in saliva and their Candida killing activity decreased with age, and these phenomena were more apparent in the patients. Furthermore, a larger number of Candida adhered to oral keratinocytes obtained from the elderly healthy controls than to those obtained from young controls. Correspondingly, keratinocytes from the aged controls showed more concanavalin-A binding sites than those from the young controls. However, oral Candida did not increase with increasing age in the controls, although an age-associated increase of oral Candida was observed in the patients. Taken together, these results indicate that the decreases of SFRs and salivary anti-candidal factors, suppression of salivary neutrophil function and the increase of candidal adhesion sites on keratinocytes predispose elderly individuals to oral candidiasis.

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Section: Candidal Adhesionmentioning

confidence: 99%

Influence of aging on candidal growth and adhesion regulatory agents in saliva

Tanida

Ueta

Tobiume

et al. 2001

J Oral Pathology Medicine

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“…[27] who demonstrated that germinated C. a/bicans had significantly greater adherence to BEC than blastospores, with germ tubes being 50 times more adherent than yeast cells. In addition, germinated yeasts were more susceptible to adherence inhibition by concanavalin A than non-germinated C. a/bicans [27]. Sobel eta/.…”

Section: Species and Strainsmentioning

confidence: 99%

“…Sandin et a/. [27] demonstrated that mannose-containing moieties on the surface of C. albicans and BEC could mediate adherence in vitro.…”

Section: Cell Surfacementioning

confidence: 99%

Pathogenicity determinants of Candida

Ghannoum

Abu-Elteen

1990

Mycoses

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The incidence of infections due to Candida albicans and other related species has increased in recent years. A number of factors have contributed to this, e.g. the use of a wide range of potent antibacterial and immunosuppressive therapeutic agents and the increased incidence of immune-deficiency diseases such as AIDS. Pathogenicity determinants which confer virulence on C. albicans, and other Candida species to a lesser extent, have been reviewed. These include factors related to species and strains, adherence, dimorphism, toxin and enzyme production and cell surface composition. This review clearly shows that C. albicans virulence is a function of a multiplicity of factors working jointly to overcome the host defences. A lack or debility in any of these parameters will reflect negatively on its infectivity and make it difficult for Candida to establish itself, particularly in a healthy individual.

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“…During the initial stages of infection the formation of hyphae may promote the adherence and penetration of host tissues. The induction of germ-tubes and hyphae has been shown to induce a 50-fold increase in binding to oral epithelial cells (Sandin et al, 1982). The promotion of apical expansion in germ-tube formation and the expression of cell surface antigens appears to be coordinately regulated (Chaturvedi et al, 1994) which may enable hyphae to attach firmly while penetration of host tissues is facilitated by the secretion of hydrolytic enzymes.…”

Section: Hyphal Transformationmentioning

confidence: 99%

Selection and pathogenicity of Candida albicans in HIV infection

1997

Oral Diseases

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The progression of immune‐suppression due to infection with HIV is mirrored by an increase in the severity and prevalence of oral candidosis. The transition of C. albicans from harmless commensal to unrelenting pathogen in the susceptible host is a fine line attributable to an extensive repertoire of selectively expressed virulence determinants, including hyphal formation, thigmotropism, protease secretion, adherence and phenotypic switching. The transition from commensal to pathogen has been linked to the formation of elongated hyphae which may more readily penetrate epithelial surfaces. Invasion may be enhanced by thigmotropism which enables hyphae to sense intercellular junctions and surface discontinuities in order to find areas that may be more readily breached. Electron micrograph studies suggest that C. albicans are able to penetrate mucosal tissues by secreting hydrolytic enzymes at the tip of the invading hyphae. Recent studies have shown that protease secretion is upregulated in C. albicans isolated from AIDS patients. Similarly, the propensity for C. albicans to adhere to oral mucosa appears to be enhanced in isolates from HIV‐infected subjects. These two virulence determinants may be coordinately regulated and DNA fingerprinting studies suggest that these phenotypic alterations may be associated with the selection of C. albicans with altered genotypes. The mechanisms by which hypervirulent C. albicans may be selected in HIV‐infected patients is likely to be a multifactorial process associated with the pathobiological effects of HIV infection and to the increased candidal proliferation so evident in these patients.

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Evidence for mannose-mediated adherence of Candida albicans to human buccal cells in vitro

Cited by 158 publications

References 25 publications

Influence of aging on candidal growth and adhesion regulatory agents in saliva

Influence of aging on candidal growth and adhesion regulatory agents in saliva

Pathogenicity determinants of Candida

Selection and pathogenicity of Candida albicans in HIV infection

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