Evidence for major genes influencing pulmonary function in the NHLBI Family Heart Study

Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution

“…Offspring-parent and sibling regression coefficients are simple estimates of heritability relative to its estimation from twin studies, family studies and segregation analyses. As has been reported previously in this and other cohorts (Devor & Crawford, 1984;Coultas et al, 1991;Klimentidis et al, 2013;Redline et al, 1989;Wilk et al, 2000;Tarnoki et al, 2013;Hukkinen et al, 2011;Hallberg et al, 2010;DeMeo et al, 2004;McClearn et al, 1994;Palmer et al, 2001;Astemborski, Beaty & Cohen, 1985;Beaty et al, 1987;Lewitter et al, 1984;Cotch, Beaty & Cohen, 1990;Chen et al, 1996;Chen et al, 1997;Givelber et al, 1998;Ingebrigtsen et al, 2011;Joost et al, 2002;Tian et al, 2017;Yamada et al, 2015), these analyses showed moderate to strong heritabilities for pulmonary function. The generally greater heritabilities for the sib-based vs. offspring-parent-based estimates have been reported by others (Givelber et al, 1998) and suggest that shared environment or dominance effects might not be negligible.…”

Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution

“…Offspring-parent and sibling regression coefficients are simple estimates of heritability relative to its estimation from twin studies, family studies and segregation analyses. As has been reported previously in this and other cohorts (Devor & Crawford, 1984;Coultas et al, 1991;Klimentidis et al, 2013;Redline et al, 1989;Wilk et al, 2000;Tarnoki et al, 2013;Hukkinen et al, 2011;Hallberg et al, 2010;DeMeo et al, 2004;McClearn et al, 1994;Palmer et al, 2001;Astemborski, Beaty & Cohen, 1985;Beaty et al, 1987;Lewitter et al, 1984;Cotch, Beaty & Cohen, 1990;Chen et al, 1996;Chen et al, 1997;Givelber et al, 1998;Ingebrigtsen et al, 2011;Joost et al, 2002;Tian et al, 2017;Yamada et al, 2015), these analyses showed moderate to strong heritabilities for pulmonary function. The generally greater heritabilities for the sib-based vs. offspring-parent-based estimates have been reported by others (Givelber et al, 1998) and suggest that shared environment or dominance effects might not be negligible.…”

Heritability of Lung Disease Severity in Cystic Fibrosis

“…Estimates of heritability obtained for cross-sectional FEV 1 in various healthy adult populations (0.5-0.77) are comparable to our estimates from individuals with CF (0.68) (48)(49)(50)(51). Whether the same or different genes contribute to cross-sectional measures of lung function in healthy individuals and those with a chronic and progressive obstructive disorder such as CF remains to be determined.…”

Heritability of pulmonary function estimated from pedigree and whole-genome markers

“…Since we did not segregate analyses to cohorts with either restrictive or obstructive disease, another potential explanation for the higher heritability of FEV 1 /FVC is a greater genetic basis for airway dynamics and airflow for which the ratio might be a more precise measure. Such differences in heritability between FEV 1 /FVC and each of the measures on their own were not observed in previous studies (Wilk et al, 2000). …”

Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution

“…Offspring-parent and sibling regression coefficients are simple estimates of heritability relative to its estimation from twin studies, family studies and segregation analyses. As has been reported previously in this and other cohorts (Devor & Crawford, 1984;Coultas et al, 1991;Klimentidis et al, 2013;Redline et al, 1989;Wilk et al, 2000;Tarnoki et al, 2013;Hukkinen et al, 2011;Hallberg et al, 2010;DeMeo et al, 2004;McClearn et al, 1994;Palmer et al, 2001;Astemborski, Beaty & Cohen, 1985;Beaty et al, 1987;Lewitter et al, 1984;Cotch, Beaty & Cohen, 1990;Chen et al, 1996;Chen et al, 1997;Givelber et al, 1998;Ingebrigtsen et al, 2011;Joost et al, 2002;Tian et al, 2017;Yamada et al, 2015), these analyses showed moderate to strong heritabilities for pulmonary function. The generally greater heritabilities for the sib-based vs. offspring-parent-based estimates have been reported by others (Givelber et al, 1998) and suggest that shared environment or dominance effects might not be negligible.…”

Heritability of Lung Disease Severity in Cystic Fibrosis

“…Estimates of heritability obtained for cross-sectional FEV 1 in various healthy adult populations (0.5-0.77) are comparable to our estimates from individuals with CF (0.68) (48)(49)(50)(51). Whether the same or different genes contribute to cross-sectional measures of lung function in healthy individuals and those with a chronic and progressive obstructive disorder such as CF remains to be determined.…”

Heritability of pulmonary function estimated from pedigree and whole-genome markers

“…Since we did not segregate analyses to cohorts with either restrictive or obstructive disease, another potential explanation for the higher heritability of FEV 1 /FVC is a greater genetic basis for airway dynamics and airflow for which the ratio might be a more precise measure. Such differences in heritability between FEV 1 /FVC and each of the measures on their own were not observed in previous studies (Wilk et al, 2000). …”

Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution

“…Offspring-parent and sibling regression coefficients are simple estimates of heritability relative to its estimation from twin studies, family studies and segregation analyses. As has been reported previously in this and other cohorts (Devor & Crawford, 1984;Coultas et al, 1991;Klimentidis et al, 2013;Redline et al, 1989;Wilk et al, 2000;Tarnoki et al, 2013;Hukkinen et al, 2011;Hallberg et al, 2010;DeMeo et al, 2004;McClearn et al, 1994;Palmer et al, 2001;Astemborski, Beaty & Cohen, 1985;Beaty et al, 1987;Lewitter et al, 1984;Cotch, Beaty & Cohen, 1990;Chen et al, 1996;Chen et al, 1997;Givelber et al, 1998;Ingebrigtsen et al, 2011;Joost et al, 2002;Tian et al, 2017;Yamada et al, 2015), these analyses showed moderate to strong heritabilities for pulmonary function. The generally greater heritabilities for the sib-based vs. offspring-parent-based estimates have been reported by others (Givelber et al, 1998) and suggest that shared environment or dominance effects might not be negligible.…”

Heritability of Lung Disease Severity in Cystic Fibrosis

“…Estimates of heritability obtained for cross-sectional FEV 1 in various healthy adult populations (0.5-0.77) are comparable to our estimates from individuals with CF (0.68) (48)(49)(50)(51). Whether the same or different genes contribute to cross-sectional measures of lung function in healthy individuals and those with a chronic and progressive obstructive disorder such as CF remains to be determined.…”

Heritability of pulmonary function estimated from pedigree and whole-genome markers

“…Since we did not segregate analyses to cohorts with either restrictive or obstructive disease, another potential explanation for the higher heritability of FEV 1 /FVC is a greater genetic basis for airway dynamics and airflow for which the ratio might be a more precise measure. Such differences in heritability between FEV 1 /FVC and each of the measures on their own were not observed in previous studies (Wilk et al, 2000). …”