Evidence for kinship between diverse G-protein coupled receptors

Evolutionary relationships among G protein-coupled receptors using a clustered database approach

“…These results confirm and extend those of Josefsson (17). Our studies support Josefssonâs finding of a large superfamily (rhodopsin-like) consisting of the following families: family A: rhodopsin, olfactory, biogenic amine, peptide receptors; family B: VIP, calcitonin, glucagon, secretin receptors; family E: fungal pheromone Aand M-factor (STE3/MAP3) receptors; family F: cAMP receptors; Arabidopsis thaliana receptors; frizzled and smoothened receptors; basal vomeronasal receptors; and ocular albinism receptors.…”

A walk-through of the yeast mating pheromone response pathway

“…Table 2 Size, mass and human homologs of the key players No a Refers to conserved domains or motifs found in animal cells. Note that although Ste2 and Ste3 are clearly seven-transmembrane (7TM), G-protein-coupled receptors, their conservation with functionallyrelated human receptors is too weak to detect, except with algorithms such as PSI-BLAST [71]. The same is true of Ste18 and human Gγ's.…”

International Union of Pharmacology. XXXV. The Glucagon Receptor Family

“…Guanine nucleotide-binding protein (G protein)-coupled receptors have been subdivided into distinct subgroups, based upon shared structural identity and evolutionary origin (Josefsson, 1999). Receptors within the family B (or family 2) subgroup, exemplified by the secretin receptor, the original family B receptor member (Ishihara et al, 1991), exhibit less homology with other GPCR 1 subfamilies and consist of three distinct subgroups, with subfamily B1 containing multiple receptors for peptide hormones (Harmar, 2001).…”